A5072257981- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Liver physiology and pathology
- Pancreatic function and diabetes
- Cytomegalovirus and herpesvirus research
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Cell Function and Interaction
- Respiratory Support and Mechanisms
- Pancreatitis Pathology and Treatment
- Clinical Nutrition and Gastroenterology
- Hepatitis C virus research
- Influenza Virus Research Studies
- Urinary Tract Infections Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gout, Hyperuricemia, Uric Acid
- Antibiotic Resistance in Bacteria
- Parvovirus B19 Infection Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Pelvic and Acetabular Injuries
- Diabetes and associated disorders
Renji Hospital
2019-2025
Shanghai Jiao Tong University
2013-2025
Shanghai Institute of Hematology
2022
State Key Laboratory of Oncogene and Related Genes
2020
Shanghai First People's Hospital
2009-2017
Shanghai Medical College of Fudan University
2016-2017
Nanjing Medical University
2016-2017
Fudan University
2006-2012
Zhongshan Hospital
2006
Sun Yat-sen University
2006
Abstract Acute lung injury (ALI) is a major component of multiple organ dysfunction syndrome (MODS) following pulmonary infection. Alveolar macrophages (AM) are at the center pathogenesis development ALI. Interleukin-1β (IL-1β) one key pro-inflammatory mediators and its maturation tightly controlled by formation activation inflammasome. The biological effects IL-1β mediated through IL-1 receptor (IL-1R). In this study, we investigated influence LPS-induced release IL-1RI upregulation on...
Dyslipidemia affects approximately half of all people with gout, and prior Mendelian randomization analysis suggested a causal role for elevated triglycerides in hyperuricemia (HU), but the underlying mechanisms remain elusive. We hypothesize that dyslipidemia promotes hepatic urate biosynthesis HU gout fatty acid (FA) oxidation (FAO) drives this process. Here we developed targeted metabolomics to quantify major metabolites purine metabolic pathway sera human cohort HU, normaluricemic...
To study lymph node metastasis (LNM) and prognosis in patients with operable hepatocellular carcinoma (HCC) as well the value of routine complete lymphadenectomy. Few studies have been reported on LNM HCC.Lymph enlargement 968 HCC was carefully explored diagnosed by typical intraoperative findings or pathology.Forty-nine (5.1%) had LNM, which associated advanced tumor properties. The 1-, 3-, 5-year overall survival poorer than those without (62.0%, 31.0%, 26.0% vs. 81.0%, 62.0%, 47.0%, P =...
Background: Liver transplantation (LT) is the most efficient treatment for pediatric patients with end-stage liver diseases, while bacterial infection leading reason post-transplant mortality. The present study to explore outcomes and risk factors of early (within 1 months) after LT. Methods: In this prospective cohort study, 1316 recipients [median (IQR) age: 9.1 (6.3–28.0) months; male: 48.0%; median follow-up time: 40.6 (29.1–51.4) months] who received LT from September 2018 April 2022...
More and more steatotic livers undergo resection or transplantation but they exhibit higher susceptibility to ischemia-reperfusion injury (IRI), which results in increased perioperative complication morbidity mortality. IRI is driven by various cytokines receptors, both of are extensively modified N-glycosylation. We aim elucidate from the perspective Differentially expressed genes glycoproteins were identified with RNA-seq N-glycoproteomics. Myeloid LIF hepatocyte LIFR knockout mice...
Postoperative interferon-alpha (IFN-alpha) therapy improved survival in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The identification of predictive markers outcome will help to select who are most likely benefit from treatment.An immunohistochemical study P48 was performed on specimens that were collected a randomized trial received postoperative IFN-alpha (Group 1; n = 80 patients) and did not receive 2; 75 patients). Positive expression graded as >/=20%...
Introduction: Severe and acute exacerbation of chronic obstructive pulmonary disease (COPD) is associated with a high mortality. Since COPD an airway inflammatory disease, heparin has shown anti-inflammatory effects in previous studies, we evaluated the clinical effect low molecular weight (LMWH; nadroparin) patients admitted into hospital due to exacerbations. Methods: Sixty-six intensive care unit (ICU) were randomly divided control group (n = 33) LMWH 33). The received conventional...
Abstract Background Acute liver failure (ALF) is a complicated condition that characterized by global hepatocyte death and often requires immediate transplantation. However, this therapy limited shortage of donor organs. Mesenchymal stem cells (MSCs) hepatocytes are two attractive sources cell-based therapies to treat ALF. The combined transplantation MSCs considered be more effective for the treatment ALF than single-cell We have previously demonstrated HNF4α-overexpressing human umbilical...
Background: Ceftazidime-avibactam (CZA) has been approved in vitro activity against carbapenem-resistant K. pneumoniae (CRKP), but the experience for treatment of CRKP liver transplantation (LT) recipients was limited, and previous data on its efficacy this setting are lacking. Methods: LT with infection who received CZA were reviewed retrospectively, microbiological clinical response, adverse events also assessed. The primary outcome 30-day mortality after administration. Results: used 21...
The study was designed to investigate the JAK2/STAT3 signaling pathway in pancreatitis and its association with inflammation cell death provide a potential treatment method for pancreatitis.The rat pancreatic acinar AR42J cells were used study, they transfected JAK2 STAT3 siRNAs mimic knockdown condition. Cerulein treat cells. Western blot ELISA employed detect expression of related proteins. Flow cytometry done analysis necrosis cells.In this we found that secretion IL-6 TGF-β1...
Ulinastatin (UTI) is a urinary trypsin inhibitor extracted and purified from urine of males. This study aimed to explore the effects UTI on paraquat-induced-oxidative stress in human type II alveolar epithelial cells.The cells, A549 were cultured vitro. The cells treated with different concentrations paraquat (200, 400, 600, 800, 1 000, 200 µmol/L) ulinastatin(0, 2 4 6 8 000 U/mL) for 24 hours, cell viability was measured by counting kit-8 median lethal concentration selected. In order...
Background & AimsChemokine-mediated immune cell recruitment plays pivotal roles in liver inflammation. C-C motif chemokine ligand 5 (CCL5) has been shown to be responsible for the of monocytes/macrophages and implicated various diseases, including nonalcoholic fatty disease, fibrosis, hepatocellular carcinoma. Previous studies have also that inhibition CCL5 appears a promising therapeutic approach several chronic diseases. However, whether blocking could benefit cell–mediated hepatitis...
To clarify the potential effect of long non-coding RNA (lncRNA) TATDN1 on accelerating proliferative rate and cell cycle progression hepatocellular carcinoma (HCC) via sponging miRNA-6089, thus participating in HCC.TATDN1 expression HCC tissues normal was first determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The correlation between to metastasis overall survival analyzed. cellular level lines examined as well. Regulatory effects viability HepG2 SMMC7721 cells were...
Objectives The hospitalization and mortality rate from COVID-19 appears to be higher in liver transplant recipients when compared with general populations. Vaccination is an effective strategy reduce the risk during pandemic. We aimed evaluate vaccine hesitancy recipients. Methods In April 2022, we conducted online-based survey through WeChat platform investigate vaccination among followed at Shanghai Renji Hospital further explore possible influencing factors. Survey items included multiple...
The aim of the present study was to observe and compare sedative effect different doses DEX on heart rate (HR) blood pressure (BP) in critically ill patients admitted intensive care units (ICUs). included that were retained ICUs required sedation between January March 2014. Patients excluded if they had a BP >200 mmHg, HR <60 bpm or state shock. randomized into three groups: Group A, 1.0 µg/kg/10 min DEX; group B, 0.5 C, 0.4 µg/kg/h DEX. After receiving these initial designated via an...
Abstract Early allograft dysfunction (EAD) is a frequent phenomenon, leading to increased graft loss and higher mortality after liver transplantation (LT). Despite significant efforts for early diagnosis of EAD, there no existing approach that can predict EAD on the first post‐operative day. The aim define metabolite‐based biomarker day LT complicated with EAD. Ten patients diagnosed 26 non‐EAD are recruited study. A HPLC‐MS/MS used determine 14 amino acids 15 bile serum concentration....
Background: Acute kidney injury (AKI) is a severe disease in critically ill patients. Neutrophil infiltration into was associated with the development of AKI, and P-selectin may be involved process neutrophil recruitment kidney. This study aimed to explore potential effect platelet-derived on mouse model sepsis-induced AKI. Methods: A total 30 C57BL/6 male mice were divided five groups (n = 6 each): sham group, sepsis anti-Ly6G anti-P-selectin platelet depletion group. Sepsis induced by...
Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal hyperinflammatory disorder characterized by dysfunctional cytotoxic T and natural killer cells. Liver transplantation predisposing factor for HLH. High mortality rates were reported in 40 cases of HLH following liver adults children. Herein, we describe case adult triggered cytomegalovirus (CMV) infection shortly after transplantation. The patient was successfully treated with ruxolitinib combined modified HLH-2004...