A5100701324- Connexins and lens biology
- Intraocular Surgery and Lenses
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Cancer-related molecular mechanisms research
- Retinal Development and Disorders
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cardiovascular Disease and Adiposity
- Biochemical effects in animals
- Aldose Reductase and Taurine
- MicroRNA in disease regulation
- Retinal Imaging and Analysis
- Photoreceptor and optogenetics research
- Retinal and Optic Conditions
- Ocular Infections and Treatments
- Atherosclerosis and Cardiovascular Diseases
- HIV-related health complications and treatments
- Advanced Glycation End Products research
- Corneal Surgery and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Visual perception and processing mechanisms
- Urinary Bladder and Prostate Research
Sun Yat-sen University
2015-2025
Hebei Medical University
2025
First Affiliated Hospital of Hebei Medical University
2025
Huazhong University of Science and Technology
2024-2025
Baotou Central Hospital
2025
Union Hospital
2024-2025
Inner Mongolia University
2025
First Affiliated Hospital of Zhengzhou University
2025
Shanghai Jiao Tong University
2025
Shanghai First People's Hospital
2025
Ischemia-reperfusion injury (IRI) is a major obstacle in liver transplantation, especially with steatotic donor livers. Dysbiosis of the gut microbiota has been implicated modulating IRI, and Lachnospiraceae plays pivotal role regulating host inflammatory immune responses, but its specific transplantation IRI remains unclear. This study explores whether can mitigate underlying mechanisms. We found Lachnospiraceae-bacterium (Lachn.) abundance was significantly reduced rats cirrhosis....
DNA methylation is an important type of epigenetic modifications, where 5- methylcytosine (5mC), 6-methyadenine (6mA) and 4-methylcytosine (4mC) are the most common types. Previous efforts have been largely focused on 5mC, providing invaluable insights into regulation through methylation. Recently developed single-molecule real-time (SMRT) sequencing technology provides a unique opportunity to detect less studied 6mA 4mC modifications at single-nucleotide resolution. With rapidly increased...
Background Electronic medical records provide large-scale real-world clinical data for use in developing decision systems. However, sophisticated methodology and analytical skills are required to handle the datasets necessary optimisation of prediction accuracy. Myopia is a common cause vision loss. Current approaches control myopia progression effective but have significant side effects. Therefore, identifying those at greatest risk who should undergo targeted therapy great importance. The...
Abstract Cold- and β3-adrenoceptor agonist-induced sympathetic activation leads to angiogenesis UCP1-dependent thermogenesis in mouse brown white adipose tissues. Here we show that endothelial production of PDGF-CC during tissue (WAT) regulates WAT browning. We find genetic deletion VEGFR2, knockout the Pdgf-c gene or pharmacological blockade PDGFR-α impair WAT-beige transition. further stimulation upregulates UCP1 expression acquisition a beige phenotype differentiated WAT-PDGFR-α +...
There is increasing need to expand availability of donor liver grafts, including steatotic livers. However, the current use grafts in transplantation less acceptable due their higher susceptibility ischemia-reperfusion (I/R) injury. To investigate mechanism underlying I/R injury, we detected cell death markers and inflammation clinical livers animal models. We found that caspase-8-mediated hepatic apoptosis activated I/R. ablation caspase-8 only slightly mitigated injury without affecting...
In this study, we synthesized 12 monofunctional tridentate ONS-donor salicylaldimine ligand (L)-based Ru(II) complexes with general formula [(Ru(L)(p-cymene)]+·Cl– (C1-C12), characterized by 1H NMR, 13C UV, FT-IR spectroscopy, HR-ESI mass spectrometry, and single-crystal X-ray analysis showing ligand's orientation around the center. All of these were tested for their anticancer activities in multiple cancer cells. The superior antitumor efficacy C2, C8, C11 was demonstrated reduced...
Glaucoma, a blinding neurodegenerative disease, whose risk factors include elevated intraocular pressure (IOP), age, and genetics, is characterized by accelerated progressive retinal ganglion cell (RGC) death. Despite decades of research, the mechanism RGC death in glaucoma still unknown. Here, we demonstrate that genetic effect SIX6 variant (rs33912345, His141Asn) enhanced another major POAG gene, p16INK4a (cyclin-dependent kinase inhibitor 2A, isoform INK4a). We further show upregulation...
Background: Ischemic stroke (IS) is more common every year, the condition serious, and have a poor prognosis. New, efficient, safe therapeutic targets are desperately needed as early treatment especially prevention reperfusion key to lowering occurrence of poorer Generally circulating proteins attractive targets, this study aims identify potential pharmacological among plasma cerebrospinal fluid (CSF) for IS using multicenter Mendelian randomization (MR) approach. Methods: First, genetic...
PAX6 is a master regulatory gene involved in neuronal cell fate specification. It also plays critical role early eye field and subsequent limbal stem (LSC) determination during development. Defects Pax6 cause aniridia LSC deficiency humans the Sey (Small eye) phenotype mice (Massé, K., Bhamra, S., Eason, R., Dale, N., Jones, E. A. (2007) Nature 449, 1058-1062). However, how specifies corneal fates development not well understood. Here, we show that expressed primitive cup later tissue...
Soil particle size fractions (PSFs) are important properties for understanding the physical and chemical processes in soil systems. Knowledge about distribution of PSFs is critical sustainable management. Although log-ratio transformations have been widely applied to prediction, statistical original data transformed given by different, resulting biased estimates PSFs. Therefore, multivariate random forest (MRF) was utilized simultaneous prediction PSFs, as it able capture dependencies...
We aimed to investigate the ultrastructures of clear corneal incisions 24 hours after phacoemulsification using anterior segment optical coherence tomography (AS-OCT).Sixty eyes 60 patients scheduled for cataract surgery were randomly selected. All underwent same procedure carried out by one experienced surgeon. Two-plane temporal tunnel performed. The types intraocular lens and implant system used in all patients. Images taken AS-OCT before 1 day surgery.Corneal thickness increased at...
T-cell development in the thymus is largely controlled by an epigenetic program, involving both DNA methylation and histone modifications. Previous studies have identified Cxxc1 as a regulator of cytosine 3 lysine 4 trimethylation (H3K4me3). However, it unknown whether plays role thymocyte development. Here we show that severely impaired Cxxc1-deficient mice. Furthermore, identify genome-wide Cxxc1-binding sites H3K4me3 modification wild-type thymocytes. Our results demonstrate directly...
Long-term uninterrupted therapy is essential for maximizing clinical benefits of antiangiogenic drugs (AADs) in cancer patients. Unfortunately, nearly all clinically available AADs are delivered to patients using disrupted regimens. We aim develop lifetime, nontoxic, effective, orally active, and low-cost antitumor treatment Here we report our findings long-term maintenance with low cost chemotherapeutics effective treatment. In a sequential regimen, robust effects tumors were achieved an...
Introduction: Homeobox genes are highly conserved and play critical roles in brain development. Recently we have found that mammals an additional fragment of approximately 20 amino acids Emx1 a poly-(Ala)6-7 Emx2, compared to other amniotes. It has been shown Emx2 synergistic actions the These reports raise interesting issue whether differences between non-mammals concerned with organization evolution amniote pallium. Methods: Lentiviruses expressing mouse (mEmx1/2) fragments were injected...
Atherosclerosis is the main cause of ischemic stroke. It occurs as a condition that leads to thickening arterial blood vessel walls and narrowing vessels, which can seriously affect normal flow blood. Currently, detection stenosis relies on large-scale hospital equipment like computed tomography (CT) magnetic resonance imaging (MRI), require specialized technicians operate are not convenient for daily use. In addition, affects multiple parameters hemodynamics in field, relying single...
Purpose Atypical teratoid/rhabdoid tumors (ATRTs) are very rare, highly malignant embryonal neoplasms in central nervous system. The aim of this study was to conduct a retrospective analysis ATRT patient survival and investigate the prognostic factors associated with ATRT. Methods A conducted using information patients who received treatment between 2016 2021 Beijing Tiantan Hospital. Kaplan–Meier curves were used for overall (OS) analysis. Univariate multivariate COX analyses applied OS...
Introduction: A cross-sectional design to evaluate high-density lipoprotein cholesterol (HDL-C) and fasting blood glucose (FBG) as novel biomarkers for assessing the risk of geriatric comorbidities. Based on data from 316 patients with comorbidities, participants were selected through hospital records according predefined inclusion exclusion criteria. The primary outcome measures include impact HDL-C FBG levels severity comorbidities calibration decision utility nomogram prediction model....