A5068293897- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Plant Virus Research Studies
- Renal cell carcinoma treatment
- Liver physiology and pathology
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Microbial Natural Products and Biosynthesis
- Plant Pathogenic Bacteria Studies
- Agronomic Practices and Intercropping Systems
- Pancreatic and Hepatic Oncology Research
- HIV/AIDS drug development and treatment
- Autophagy in Disease and Therapy
- Metabolism and Genetic Disorders
- Plant-Microbe Interactions and Immunity
- Antifungal resistance and susceptibility
Hebei Medical University
2016-2025
Third Hospital of Hebei Medical University
2016-2025
Ankang University
2021-2024
Renji Hospital
2018-2024
Shanghai Jiao Tong University
2009-2023
Hebei Provincial Center for Disease Control and Prevention
2022-2023
Jingzhou Central Hospital
2023
Chongqing Dazu District People's Hospital
2022
Shanghai Institute of Hematology
2014-2022
Northwest A&F University
2019-2020
Monotherapy with pegylated interferon alpha (Peg-IFNa) or adefovir dipivoxil (ADV) to HBeAg-positive chronic hepatitis B (CHB) patients has limited effects. This study aims evaluate therapeutic efficacy and safety of individualized combination therapy Peg-IFNa ADV.HBeAg-positive CHB (n=160) were enrolled in this multi-center, prospective, randomized, 'real-life' cohort study, which received Peg IFNa-2a monotherapy ADV base on the baseline features treatment response.At week 24, percentages...
Despite progress in the diagnostics and treatment of hepatocellular carcinoma (HCC), its prognosis remains poor. In this study, we globally assessed long noncoding RNAs (lncRNA) for contributions to HCC using publicly available microarray data, vitro vivo assays. Here, report that ZFAS1, encoding a lncRNA is frequently amplified HCC, associated with intrahepatic extrahepatic metastasis poor HCC. ZFAS1 functions as an oncogene progression by binding miR-150 abrogating tumor-suppressive...
Background Simvastatin exerts pleiotropic effects on cardiovascular system. However, its effect non-alcoholic fatty liver disease, especially the fibrosis, remains obscure. We aimed to clarify relationship between simvastatin and fibrosis both in vivo vitro. Methods A High-fat diet was given establish rat models with steatohepatitis (NASH)-related (4mg·kg-1·d-1) administrated intragastrically until hepatic histological findings confirmed appearance of fibrosis. Human stellate cell (HSC) line...
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related mortality worldwide. Despite progress in diagnostics and treatment HCC, its prognosis remains poor because molecular mechanisms underlying hepatocarcinogenesis are not well understood. In study, we focused on identifying role miRNAs HCC progression. miRNA microarray was used to analyze differentially expressed miRNAs, results were validated by qPCR. We found that miR-150-5p expression down-regulated tissues compared...
Summary Virus‐like particles encapsulating HBV‐RNA represent a serum biomarker for assessing viral replication activity in clinical practice. However, baseline levels of and their associations with replicative intermediates liver disease phases chronic hepatitis B remain unknown. In this cross‐sectional study, 102 patients were categorized into immune‐tolerant (IT), HBeAg‐positive immune active (HBeAg+IA), inactive carrier (IC) HBeAg‐negative (HBeAg‐IA) phases. samples 66 paired biopsies...
Insulin-like growth factor-1 receptor (IGF-1R) is a well-studied oncogenic factor that promotes cell proliferation and energy metabolism overexpressed in numerous cancers including hepatocellular carcinoma (HCC). Aerobic glycolysis hallmark of cancer, drugs targeting its regulators, IGF-1R, are being developed. However, the mechanisms IGF-1R inhibition physiological significance inhibitors cancer cells unclear.Cell was evaluated by counting Kit-8 colony formation assay. Western blot...
Nonalcoholic fatty liver disease (NAFLD) is one of the critical public health problems in China. The full spectrum ranges from simple steatosis and nonalcoholic steatohepatitis (NASH) to cirrhosis hepatocellular carcinoma(HCC). infiltration inflammatory cells characterizes NASH. This characteristic contributes progression hepatitis, fibrosis, cirrhosis, HCC. Therefore, distinguishing NASH NAFLD crucial.Ninety-five patients with NAFLD, 44 NASH, 51 non-NASH were included study develop a new...
The relationship between resistin and non-alcoholic steatohepatitis (NASH) is not clear, some studies claimed that serum levels were associated with neither the presence of NASH nor its severity, others declared was related inflammation fibrosis in NASH. Our animal study verified distribution liver correlated However, there no pertinent humans. Thirty patients NASH, 28 simple steatosis, 43 controls recruited. Blood collected for resistin, chemistries, fasting insulin metabolic parameters....
Abstract Background Cytochrome P450 (Cytochrome P450s) genes are involved in the catalysis of various reactions, including growth, development, and secondary metabolite biosynthetic pathways. However, little is known about characteristics functions gene family Camellia sinensis ( C. ). Results To reveal mechanisms tea plant P450s coping with abiotic stresses, analyses were conducted using bioinformatics-based methods. In total, 273 putative identified from genome database . The results...
This report described a male patient presenting with recurrent fever, fatigue, persistent abdominal distension, and diarrhea, who was repeatedly misdiagnosed decompensated cirrhosis at multiple hospitals. The diagnostic process complex, ultimately leading to the diagnosis of TAFRO syndrome through lymph node bone marrow biopsies, following 18 F-FDG PET/CT imaging. initially responded treatment, while later succumbed severe intra-abdominal infection organ failure. syndrome, rare subtype...
Intercropping systems have garnered attention as a sustainable agricultural approach for efficient land use, increased ecological diversity in farmland, and enhanced crop yields. This study examined the effect of intercropping on kiwifruit rhizosphere to gain deeper understanding relationships between cover plants this system. Soil physicochemical properties bacterial communities were analyzed using Kiwifruit-Agaricus blazei System. Moreover, combined analysis 16S rRNA gene sequencing...
The aim of this study was to investigate the changes in splanchnic hemodynamics after LDLT and their relationship with graft regeneration. Eighteen patients December 2006 June 2008 were enrolled, color Doppler ultrasonography performed preoperatively on postoperative days (PODs) 1, 3, 5, 7, 30, 90 transplantation. portal blood flow mean velocity (PBV) volume (PBF) monitored, effects hepatic function observed simultaneously. Graft sizes measured PODs operation. regeneration rates grafts...
Farnesoid X receptor (FXR) is the nuclear of bile acids and involved in innate immune regulation. FXR agonists have been shown to protect multiple organs from inflammatory tissue injuries. Because liver expresses high levels FXR, we explored potential therapeutic benefits underlying mechanisms pharmacologic activation a murine model partial warm ischemia. Pretreatment mice with agonist 3‐(2,6‐dichlorophenyl)‐4‐(3′‐carboxy‐2‐chlorostilben‐4‐yl)oxymethyl‐5‐isopropylisoxazole (GW4064)...
Sorafenib resistance is a major challenge in the therapy for advanced hepatocellular carcinoma (HCC). However, underlying molecular mechanisms of HCC to sorafenib remain unclear. Activator thyroid and retinoid receptor (ACTR, also known as SRC-3), overexpressed patients, plays an important oncogenic role HCC; however, link between ACTR unknown. Our study demonstrated that was one most upregulated genes sorafenib-resistant xenografts. increases through regulation Warburg effect. promotes...