Zhigang Li

ORCID: 0000-0003-0378-3496
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About
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Research Areas
  • Acupuncture Treatment Research Studies
  • Traditional Chinese Medicine Studies
  • Healthcare and Venom Research
  • Alzheimer's disease research and treatments
  • Neurological Disease Mechanisms and Treatments
  • Gastrointestinal motility and disorders
  • Complementary and Alternative Medicine Studies
  • Spinal Cord Injury Research
  • Nerve injury and regeneration
  • Medicinal Plants and Bioactive Compounds
  • Tea Polyphenols and Effects
  • Biochemical effects in animals
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Stress Responses and Cortisol
  • Food Quality and Safety Studies
  • Medical Research and Treatments
  • Inflammasome and immune disorders
  • Tryptophan and brain disorders
  • Biofield Effects and Biophysics
  • Photoacoustic and Ultrasonic Imaging
  • Automotive and Human Injury Biomechanics
  • Music Therapy and Health
  • Cardiac Imaging and Diagnostics
  • Thermoregulation and physiological responses
  • Apelin-related biomedical research

Beijing University of Chinese Medicine
2016-2025

Binzhou Medical University
2024

Guangxi University
2024

University of Science and Technology Beijing
2024

Nankai University
2024

Beijing Children’s Hospital
2024

First Affiliated Hospital of Zhengzhou University
2018-2023

Henan Provincial Center for Disease Control and Prevention
2023

Tea Research Institute
2020-2023

Guangdong Academy of Agricultural Sciences
2020-2023

Abstract Acute lung injury (ALI) is a major component of multiple organ dysfunction syndrome (MODS) following pulmonary infection. Alveolar macrophages (AM) are at the center pathogenesis development ALI. Interleukin-1β (IL-1β) one key pro-inflammatory mediators and its maturation tightly controlled by formation activation inflammasome. The biological effects IL-1β mediated through IL-1 receptor (IL-1R). In this study, we investigated influence LPS-induced release IL-1RI upregulation on...

10.1038/srep31663 article EN cc-by Scientific Reports 2016-08-16

Spinal cord injury(SCI) often leads to severe and permanent paralysis places a heavy burden on individuals, families society. Until now, the therapy of SCI is still big challenge for researchers. Transplantation mesenchymal stem cells (MSCs) hot spot treatment spinal injury, but many problems risks have not been resolved. Some studies reported that therapeutic effect MSCs injury related paracrine secretion cells. The exosomes secreted by potential diseases. There are abundant pericytes which...

10.3389/fnins.2019.00319 article EN cc-by Frontiers in Neuroscience 2019-04-16

Aim: The optimal maintenance therapy for active diffuse lupus nephritis remains to be established. In this study, we explored the efficacy and safety of tacrolimus maintaining remission compared that azathioprine. Methods: Seventy patients with biopsy-proven who achieved were enrolled in nine nephrology centers China from 2006 2008. Patients randomized either plus prednisone ( n = 34) or azathioprine 36) six months. Tacrolimus was titrated achieve a trough blood concentration 4–6 ng/mL,...

10.1177/0961203312442259 article EN Lupus 2012-03-21

A Morris water maze (MWM) experiment forces experimental animals to swim and learn find a platform hidden in the water. It is widely used scientific research assess learning memory of animals. Due extensive use MWM test, visual protocols are essential for researchers. This manuscript uses latest studies introduce protocol test. Alzheimer’ Disease (AD) characterized by progressive loss cognitive function. An alternative complementary treatment AD Manual Acupuncture (MA). To ability model...

10.3791/60055 article EN Journal of Visualized Experiments 2019-10-29

<h3>Importance</h3> Alcohol is the most common drug among youth and a major contributor to morbidity mortality worldwide. Billions of dollars are spent annually marketing alcohol. <h3>Objective</h3> To examine reach television alcohol advertising its effect on drinking underage youth. <h3>Design, Setting, Participants</h3> Longitudinal telephone- web-based surveys conducted in 2011 2013 involving 2541 US adolescents 15 23 years age at baseline, with 1596 these completing follow-up survey....

10.1001/jamapediatrics.2014.3345 article EN JAMA Pediatrics 2015-01-19

Background: A growing body of evidence has demonstrated that cerebrovascular function abnormality plays a key role in occurrence and worsening Alzheimer's disease (AD). Reduction cerebral blood flow (CBF) is sensitive marker to early perfusion deficiencies AD. As one the most important therapies complementary alternative medicine, manual acupuncture (MA) been used treatment However, moderating effect MA on CBF remains largely unknown. Objective: To investigate behavior SAMP8 mice. Methods:...

10.3389/fnins.2019.00037 article EN cc-by Frontiers in Neuroscience 2019-01-30

Selective serotonin reuptake inhibitors (SSRIs) are first-line antidepressants, however, only around 60% of patients could benefit from them. Acupuncture is supported by insufficient evidence to help with symptom relieving and SSRIs tolerance. This pragmatic randomized controlled trial compared alone versus together manual acupuncture (MA) or electroacupuncture (EA) in moderate severe depressed patients. Patients were randomly allocated receive MA + (161), EA (160), (156) for six weeks, then...

10.1016/j.jpsychires.2019.04.005 article EN cc-by-nc-nd Journal of Psychiatric Research 2019-04-09

Objective: Investigating the effects of electro-acupuncture (EA) treatment on mice with Alzheimer's disease (AD), using Morris water maze (MWM) for spatial learning and memory behavior tests combined micro-positron emission tomography (micro-PET) imaging glucose metabolism in hippocampus. Methods: Thirty seven-month-old APP/PS1 were randomly divided into AD Model group (AD group), medicine (M group) EA group, C57BL/6 used Normal control (N n = 10 each group. Mice M received donepezil...

10.3389/fnagi.2017.00005 article EN cc-by Frontiers in Aging Neuroscience 2017-01-24

Mast cells (MCs) play a crucial role in mediating the establishment of networks among circulatory, nervous and immune system at acupoints. However, changes which occur MCs during acupoint sensitization, i.e. dynamic transformation an from "silenced" to "activated" status, remain uncharacterized. To investigate morphological functional as aid understanding cellular mechanism underlying rat model knee osteoarthritis (OA) was induced by injection mono-iodoacetate (MIA) on day 0. On 14,...

10.1371/journal.pone.0194022 article EN cc-by PLoS ONE 2018-03-07

To explore the effects of acupuncture (manual or electroacupuncture) combined with SSRIs for moderate to severe depression improving major clinical symptoms and life quality patients on secondary outcomes.Pragmatic, parallel, randomized controlled trial.6 hospitals in China.6 weeks manual (MA)+selective serotonin reuptake inhibitors (SSRIs), electroacupuncture (EA)+SSRIs, alone.The primary outcome was response rate 17-item Hamilton Depression Scale (HAMD-17) total score at 6th week. The...

10.1016/j.ctim.2019.03.015 article EN cc-by-nc-nd Complementary Therapies in Medicine 2019-03-27

Introduction. Alzheimer's disease (AD) causes progressive hippocampus dysfunctions leading to the impairment of learning and memory ability low level uptake rate glucose in hippocampus. What is more, there no effective treatment for AD. In this study, we evaluated beneficial protective effects electroacupuncture senescence-accelerated mouse prone 8 (SAMP8). Method. paradigm, was performed once a day 15 days on 7.5-month-old SAMP8 male mice. normal control paradigm AD group, SAMR1 mice were...

10.1155/2015/142129 article EN Evidence-based Complementary and Alternative Medicine 2015-01-01

Effective therapies for Alzheimer's disease (AD) are still being explored. Electroacupuncture with traditional Chinese medicine theory may improve spatial learning and memory abilities glucose metabolism rates in an animal model of AD. However, the mechanism electroacupuncture intervention AD is unclear. According to recent studies mechanisms, NLRP3 inflammasome regulated expression IL-1β brain which mediate related processes. Therefore, our study, we intend explore possible relation between...

10.1155/2018/8296824 article EN cc-by Evidence-based Complementary and Alternative Medicine 2018-01-01

Electroacupuncture (EA) has become popular for its adjustable strength and frequency easy quantification in the clinic demonstrated therapeutic potential Alzheimer's disease (AD). However, mechanism remains unknown. Abnormally activated c-Jun N-terminal kinase (JNK) been closely related to pathological process of AD. The aim this study was investigate effect EA on cognitive impairment role JNK signaling pathway AD model amyloid precursor protein (APP)/presenilin 1 (PS1) mice. memory learning...

10.3389/fnagi.2020.00023 article EN cc-by Frontiers in Aging Neuroscience 2020-02-06

The quality of traditional Chinese medicine is based on the content their secondary metabolites, which vary with habitat adaptation and ecological factors. This study focuses

10.3389/fpls.2024.1397939 article EN cc-by Frontiers in Plant Science 2024-08-06

Considering the emerging educational paradigm, there is a pressing need for reform in acupuncture education. We uses education at Beijing University of Chinese Medicine as case to delineate challenges encountered current theoretical and practical teaching proposes viable solutions. In teaching, should be an emphasis on classical theories integrated with modern scientific provide more comprehensive understanding theories. As training, endeavors made enhance clinical application leverage...

10.1089/acu.2024.0129 article EN Medical Acupuncture 2025-01-21

A Morris water maze (MWM) experiment forces experimental animals to swim and learn find a platform hidden in the water. It is widely used scientific research assess learning memory of animals. Due extensive use MWM test, visual protocols are essential for researchers. This manuscript uses latest studies introduce protocol test. Alzheimer' Disease (AD) characterized by progressive loss cognitive function. An alternative complementary treatment AD Manual Acupuncture (MA). To ability model...

10.3791/60055-v article EN Journal of Visualized Experiments 2019-10-29

In an effort to explore new, noninvasive treatment options for spinal cord injuries (SCI), this study investigated the effects of electroacupuncture (EA) SCI rat models. was induced by a modified Allen’s weight-drop method. We response EA at Dazhui (GV 14) and Mingmen 4) acupoints understand mechanisms in neuroprotection neuronal function recovery after SCI. BBB testing used detect motor rats’ hind limbs among groups, shown promote function. Nissl staining showed restored neural morphology...

10.1155/2016/2371875 article EN cc-by Neural Plasticity 2016-01-01

The current study aimed to investigate the effects and mechanisms of electroacupuncture (EA) treatment applied Bai hui (GV20) Yin tang (GV29) acupoints (1 mA, 2 Hz, continuous wave, 20 minutes) for 28 days in a rat model chronic unpredictable mild stress (CUMS) on reuptake serotonin (5-hydroxytryptamine (5-HT)) miRNA-16 levels hippocampus serum. Rats were housed individual cages, CUMS was used establish depression. After EA 4 weeks, behavioral changes indices including 5-HT transporter...

10.1155/2019/7124318 article EN Evidence-based Complementary and Alternative Medicine 2019-12-24

Objectives: To explore whether combined therapy with donepezil and acupuncture is better than treatment or individually in a rat model of Alzheimer’s disease. Methods: In this study, we randomly divided 40 7.5-month-old senescence-accelerated mouse prone 8 (SAMP8) male mice into four groups: SAMP8, SAMP8+D, SAMP8+MA SAMP8+D+MA. An additional 10 SAMR1 were included as healthy control group (SAMR1). Mice the SAMP8+D given at dose 0.65 µg/g/day; underwent manual GV20, GV26 Yintang for 20 min...

10.1136/acupmed-2016-011310 article EN cc-by-nc Acupuncture in Medicine 2019-02-01
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