A5028899199- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Esophageal Cancer Research and Treatment
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Pneumocystis jirovecii pneumonia detection and treatment
- Gastric Cancer Management and Outcomes
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Hematological disorders and diagnostics
- MicroRNA in disease regulation
- Microbial infections and disease research
- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Bacterial Identification and Susceptibility Testing
- Microscopic Colitis
Shanghai East Hospital
2024-2025
University of Electronic Science and Technology of China
2024-2025
Tongji Hospital
2025
Huazhong University of Science and Technology
2025
Anhui Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Sichuan University
2024
State Key Laboratory of Biotherapy
2024
Jilin Medical University
2024
Jilin University
2024
The blockade of PD-1–PD-L1 pathway is emerging as an effective therapeutic strategy for several advanced cancers. But the immune regulatory role not clear in colorectal cancer (CRC) patients. This study aims to evaluate CD8+ T-cell functions tumour-draining lymph nodes (TDLNs) and tumours CRC PD-1 expression on T cells was examined by flow cytometry, PD-L1 TDLNs tumour tissues were immunohistochemistry. Production IFN-γ, IL-2 granzyme B, perforin detected intracellular staining. markedly...
STK19 was originally identified as a manganese-dependent serine/threonine-specific protein kinase, but its function has been highly debated. Here, the crystal structure of revealed that it does not contain kinase domain, three intimately packed winged helix (WH) domains. The third WH domain mediated homodimerization and double-stranded DNA binding, both being important for nuclear localization. participated in nucleotide excision repair (NER) mismatch (MMR) pathways by recruiting damage...
Summary Hepatitis C virus ( HCV ) infection is a major cause of chronic hepatitis and hepatocellular carcinoma. Currently pegylated interferon IFN combined with ribavirin remains the best therapeutic approach, although patients infected genotype I may benefit from adding protease inhibitors as ‘triple therapy’. Micro RNA s (mi s) are endogenous small noncoding that regulate gene expression have recently been shown to play an important role in human innate immune response antiviral...
The 'Yamanaka factors' (Oct4, Sox2, Klf4 and c-Myc) are able to generate induced pluripotent stem (iPS) cells from different cell types. However, what degree primary malignant can be reprogrammed into a state has not been vigorously assessed. We established an acute myeloid leukemia (AML) model by overexpressing the human mixed-lineage leukemia-AF9 (MLL-AF9) fusion gene in mouse hematopoietic that carry Yamanaka factors under control of doxycycline (Dox). On addition Dox culture,...
This study aims to investigate the potential effect of compromised structural integrity on cerebral aging and cognitive function in small vessel disease (CSVD). Fifty-five CSVD patients 42 controls underwent three-dimensional T1-weighted imaging diffusion tensor imaging. Relative brain age (RBA) was computed assess aging. Variables included cortical thickness, volume, white matter hyperintensity (WMH) peak width skeletonized mean diffusivity (PSMD), ventricular choroid plexus volume....
<title>Abstract</title> Acetaminophen (APAP) overdose induces acute liver injury and represents the most frequent cause of drug-induced worldwide. Macrophage-mediated inflammation plays detrimental roles during early stage injury. However, potential targets regulating to improve remains undefined. In this study, we reported that G protein-coupled receptor 35 (GPR35) improves by blocking macrophage-mediated via Gαs-cyclic AMP-protein kinase A (Gαs-cAMP-PKA) pathway. The ablation GPR35...
To explore the correlation between MYB/NFIB gene fusion and clinicopathological features such as tumor grade prognosis of head neck adenoid cystic carcinoma (ACC), to assess concordant rate fluorescent in situ hybridization (FISH) with MYB NFIB immunohistochemistry.
Summary Current researches have determined the significance of C-C chemokine receptor (CCR)6 expression as either a marker T helper cells (Th) or an effector and regulator cell function. However, roles CCR6 in pathogenesis immune thrombocytopenia (ITP) are unclear. In this study, we aimed to investigate phenotype functional characteristics circulating CCR6+ blood from chronic ITP patients healthy controls. We found that frequency CCR6+CD4+ was higher than Anti-CD3/anti-CD28 stimulation...
Vaccination is one of the most economic and effective strategies for preventing infectious diseases. However, public intention to be vaccinated is, a certain degree, influenced by issues related vaccine hesitancy, anti-vaccine movement, concerns about safety adverse effects. Vaccine literacy considered as positive factor in improving vaccination intention, however, correlation between has not been thoroughly investigated mainland China. This study aims (1) explore among adults China; (2)...
Esophageal cancer is a malignant tumor with high incidence in China. At pesent, advanced esophageal patients are still frequently encountered. The primary treatment for resectable surgery-based multimodality therapy, including preoperative neoadjuvant such as chemotherapy, chemoradiotherapy or chemotherapy plus immunotherapy, followed by radical esophagectomy thoraco-abdominal two-field cervico-thoraco-abdominal three-field lymphadenectomy via minimally invasive approach thoracotomy. In...
Objective: To analyze the diagnostic value of cell-free plasma metagenomic next-generation sequencing (mNGS) pathogen identification for severe aplastic anemia (SAA) bloodstream infection. Methods: From February 2021 to 2022, mNGS and conventional detection methods (blood culture, etc.) were used detect 33 samples from 29 consecutive AA patients admitted Anemia Diagnosis Treatment Center Hematology Hospital Chinese Academy Medical Sciences assess consistency detection, as well impact on...
<h3>Introduction/Background</h3> Niraparib improves progression-free survival (PFS) in patients (pts) with newly diagnosed advanced ovarian cancer after 1st-line (1L) platinum-based chemotherapy (CT). We report the efficacy of niraparib pts by biomarker status. <h3>Methodology</h3> This double-blind, placebo (PBO)-controlled, phase 3 study randomized 733 ovarian, primary peritoneal, or fallopian tube a complete partial response (CR PR) to 1L CT. Stratification factors were best CT (CR/PR),...
Objective: To analyze the clinical and pathological features of Cronkhite-Canada syndrome (CCS), to investigate significance IgG4 positive plasma cell infiltration. Methods: Clinical presentations, endoscopic appearances morphological 18 patients diagnosed with CCS at Peking Union Medical College Hospital during 2000-2016 were included in study.There 11 male 7 female patients. IgG immunohistochemical stains performed total 55 biopsies from (36 polyps, 10 adenoma 9 surrounding mucosa) a...