A5101711094- Lung Cancer Treatments and Mutations
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Multiple Myeloma Research and Treatments
- Hemophilia Treatment and Research
- Renal Diseases and Glomerulopathies
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Pharmaceutical Economics and Policy
- Acute Myeloid Leukemia Research
- Chronic Kidney Disease and Diabetes
- Protein Degradation and Inhibitors
- Cancer Treatment and Pharmacology
- Pancreatic and Hepatic Oncology Research
- Acute Lymphoblastic Leukemia research
- Rheumatoid Arthritis Research and Therapies
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- Breast Cancer Treatment Studies
- Hematopoietic Stem Cell Transplantation
- Adolescent and Pediatric Healthcare
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Synthesis and Biological Evaluation
University of Alabama at Birmingham
2024-2025
Wenzhou-Kean University
2025
Kean University
2025
Guangdong University of Technology
2024
Analysis Group (United States)
2015-2024
First Affiliated Hospital of Wenzhou Medical University
2024
Guangzhou Medical University
2024
Boston University
2022-2024
Jingdezhen Ceramic Institute
2024
Third Affiliated Hospital of Guangzhou Medical University
2024
The aim of the current study was to assess economic impact using next-generation sequencing (NGS) versus single-gene testing strategies among patients with metastatic non-small-cell lung cancer (mNSCLC) from perspective Centers for Medicare & Medicaid Services (CMS) and US commercial payers.A decision analytic model considered who were newly diagnosed mNSCLC received programmed death ligand 1 genomic alteration tests-EGFR, ALK, ROS1, BRAF, MET, HER2, RET, NTRK1-using upfront NGS (all...
To examine the direct and indirect costs of hemophilia care among persons with A in US.Observational data were obtained from HUGS-Va, a multi-center study six federally supported treatment centers (HTCs). Eligible individuals completed standardized initial questionnaire followed regularly for 2 years to obtain information on work or school absenteeism, time spent arranging care, unpaid hemophilia-related support caregivers. Data 1-year healthcare utilization records 2-year clotting factor...
Abstract The objective of the study was to assess racial disparities in treatment and outcomes among white, African American, Hispanic patients with multiple myeloma (MM). Patients an MM diagnosis from Surveillance Epidemiology End Results (SEER)–Medicare (2007-2013) database were included. Continuous Medicare enrollment for 6 months before (baseline) after required unless death occurred. Time novel therapy initiation autologous stem cell transplant (ASCT), overall survival (OS), MM-specific...
Chronic constipation (CC) is a highly prevalent health problem, potentially associated with increased risk of colorectal cancer (CRCancer).To investigate the association between CC, its severity, and CRCancer by estimating relative developing benign neoplasm (BCN) among severity-stratified patients without CC.Chronic from large retrospective US claims database were matched 1:3 CC-free controls demographic characteristics. BCN prevalence measured over 1 year. In pre-index CRCancer- BCN-free...
NAC (no apical meristem (NAM), Arabidopsis thaliana transcription activation factor (ATAF1/2) and cup shaped cotyledon (CUC2)) factors play crucial roles in plant development stress responses. Nevertheless, to date, only a few reports regarding stress-related genes are available Malus baccata (L.) Borkh. In this study, the MbNAC25 M. was isolated as member of plant-specific family that regulates Expression induced by abiotic stresses such drought, cold, high salinity heat. The ORF is 1122...
PURPOSE Nivolumab plus relatlimab and nivolumab ipilimumab have been approved for advanced melanoma on the basis of phase II/III RELATIVITY-047 III CheckMate 067 trials, respectively. As no head-to-head trial comparing these regimens exists, an indirect treatment comparison was conducted using patient-level data from each trial. METHODS Inverse probability weighting (IPTW) adjusted baseline characteristic differences. Minimum follow-ups (RELATIVITY-047, 33 months; 067, 36 months) were...
Abstract Background. Existing treatments for metastatic breast cancer (mBC) are often effective but can cause adverse events (AEs). This study aimed to identify AEs associated with chemotherapies commonly used in mBC treatment (phase 1) and quantify the economic impact of these 2). Materials Methods. Patients phase 1 had at least one claim therapy mBC, episode single or multiple agents. The most common chemotherapy-related complications were identified using medical pharmacy claims data. In...
Background: Cancer immunotherapy has achieved great success in breast cancer treatment recent years.The Programmed Death-1 (PD-1) /Programmed Death-Ligand 1 (PD-L1) immune checkpoint pathway is among the most studied.BMS-1166, a PD-L1 inhibitor, can interfere with PD-1 and interaction.Transferrin Receptor transmembrane glycoprotein overexpressed various cells, including cancer, specifically interact T7 (HAIYPRH) peptide.Purpose: This study hypothesized that BMS-1166-loaded T7-modified...
Nowadays, chemotherapy and immunotherapy remain the major treatment strategies for Triple-Negative Breast Cancer (TNBC). Identifying biomarkers to pre-select subclassify TNBC patients with distinct responses is essential. In current study, we performed an unbiased Reverse Phase Protein Array (RPPA) on cells treated compounds found a leading significant increase of phosphor-AURKA/B/C, AURKA, AURKB, PLK1, which fall into mitotic kinase group. The AURKA AURKB protein was majorly due...
Type VI secretion system effectors (T6SEs) are crucial for bacterial pathogenicity, making their accurate identification essential understanding virulence mechanisms. This study analyzed the differences in amino acid composition of N-terminal signal sequences between T6SEs and non-T6SEs, uncovering distinct positional preferences T6SEs. Using a combination unsupervised supervised analysis, we evaluated feature encoding methods developed T6CNN, an ensemble model that integrates sequences,...
Crizotinib and ceritinib have been developed to treat advanced or metastatic NSCLC by inhibiting anaplastic lymphoma receptor tyrosine kinase gene (ALK). No randomized trial has compared these treatments head-to-head. We efficacy outcomes between patients receiving an external control group crizotinib, both as initial ALK-targeted therapies for previously treated ALK-positive NSCLC. Individual patient data the ceritinib-treated were drawn from two single-arm trials (ASCEND-1 ASCEND-3);...
9031 Background: Metastatic non-small cell lung cancer (mNSCLC) patients (pts) should be tested for genomic alterations (GA) to inform treatment decisions. This study assesses the economic impact of next generation sequencing (NGS) vs sequential single-gene testing modalities Center Medicare and Medicaid Services (CMS) US commercial payers. Methods: In a decision analytic model, newly diagnosed mNSCLC pts were modeled receive PD-L1 GA tests (EGFR, ALK, ROS1, BRAF, MET, HER2, RET, NTRK1)...
This article examines the effect of regional trade agreements (RTAs) with and without environmental provisions on concentration PM2.5 (fine particulate matter ≤2.5μm in diameter), which is one most significant air pollutants. Using panel data for 136 countries from 2001 to 2010, we estimate liberalization under RTAs regulations provisions. Moreover, paired are used examine convergence concentrations. Human behaviours natural characteristics added as control variables, potential endogeneity...
The randomized phase III KEYNOTE-522 trial demonstrated that addition of pembrolizumab to neoadjuvant chemotherapy provided a significant improvement in event-free survival and favorable trend overall for high-risk early-stage triple-negative breast cancer (eTNBC). This analysis evaluated the cost-effectiveness combination with as treatment continued single-agent adjuvant after surgery vs. patients eTNBC USA.The was conducted from US third-party public healthcare payer perspective. A...
Upfront next-generation sequencing (NGS) in patients with metastatic NSCLC has been associated cost savings and shorter time-to-test results the United States. Nevertheless, this may not apply jurisdictions where prevalence of actionable mutations, health care, reimbursement models differ.
Summary Regular participation in physical activity helps to prevent damage and maintain joint health persons with haemophilia. This study describes self‐reported among a sample of people haemophilia B the US measures its association health‐related quality life ( HRQ oL). Data on 135 participants aged 5–64 years were abstracted from Hemophilia Utilization Group Study Part Vb. The International Physical Activity Questionnaire assessed 15–64 years, Children's Canadian Community Health Survey...
Interstitial lung disease (ILD) is a common manifestation of scleroderma/systemic sclerosis (SSc). However, the direct and indirect economic burdens SSc-ILD remain unclear. This study assessed compared healthcare resource utilization (HRU), costs, work loss, costs between patients with matched controls neither SSc nor ILD in USA. Data were obtained from large US commercial claims database (2005–2015). Patients (at least 18 years old) had at one diagnosis inpatient (IP) or emergency room (ER)...
Aims: To evaluate the cost-effectiveness of adjuvant pembrolizumab relative to observation alone following complete resection high-risk stage III melanoma with lymph node involvement, from a US health system perspective.Materials and methods: A Markov cohort model four states (recurrence-free, locoregional recurrence, distant metastases, death) was developed estimate costs, life-years, quality-adjusted life-years (QALYs) associated vs over lifetime (46-year) horizon. Using parametric...