Stroke is a major cause of long-term disability in the United States. This study examined national impact stroke on health-related quality life (HRQoL) and disparities HRQoL across different demographic groups.

Background— A hub-and-spoke telestroke network is an effective way to extend quality acute stroke care remote hospitals and improve patient outcomes. This study assessed the cost-effectiveness of a in management ischemic from perspectives network, hub hospital, spoke hospital. Methods Results— model was developed compare costs effectiveness with without over 5-year time horizon. The considered differences rates teleconsultations, intravenous thrombolysis, endovascular therapies, spoke-to-hub...

Background— Coronary heart disease (CHD) affects 15.8 million Americans. However, data on the national impact of CHD health-related quality life, particularly among people different age, sex, racial, and ethnic groups, are limited. Methods Results— Using from 2000 2002 Medical Expenditure Panel Survey, we examined various measures patient-reported health status, including in non-CHD populations differences demographic subgroups. These included short-form generic (Short Form 12; Mental...

Abstract The objective of the study was to assess racial disparities in treatment and outcomes among white, African American, Hispanic patients with multiple myeloma (MM). Patients an MM diagnosis from Surveillance Epidemiology End Results (SEER)–Medicare (2007-2013) database were included. Continuous Medicare enrollment for 6 months before (baseline) after required unless death occurred. Time novel therapy initiation autologous stem cell transplant (ASCT), overall survival (OS), MM-specific...

Objective: To evaluate health care utilization and costs for patients with psoriasis vs. the general population by severity.Research design methods: Claims data were analyzed adult ≥1 diagnosis of continuous enrollment during year 2003 (case sample). A control sample was matched 2:1 on baseline demographic characteristics to case sample. Case samples further stratified severity based treatment patterns. Outcomes compared descriptively a multivariate two-part model differences between groups...

Abstract Background Teduglutide reduces or eliminates parenteral support (PS) dependency in patients with short bowel syndrome (SBS). Recent post hoc analyses demonstrated that effects are correlated baseline PS volume. We assessed the SBS‐related quality‐of‐life (QoL) impact of teduglutide, particularly whether improvements greater among subgroups achieving more volume reduction. Methods Using phase 3 trial data teduglutide SBS (NCT00798967), change Short Bowel Syndrome–Quality Life...

Abstract Objective: To understand prevalence, severity, impact, and treatment of vasomotor symptoms associated with menopause, using cross-sectional survey data. Methods: This online, two-part was conducted in East Asia among women 40-65 years recruited from established online panels (Edelman, Beijing; Hankook Research, Seoul; Rakuten Insight, Taipei) stratified sampling. Part I collected demographics/disease characteristics, including menopausal status symptom severity. Women...

Abstract Background Pneumococcal disease (PD) is a group of infections that can have significant yet poorly understood impact on health-related quality life (HRQoL). This meta-analysis aims to quantify the HRQoL PD. Methods Original research studies reporting health utility, disutility, quality-adjusted year (QALY), or QALY decrement associated with PD were identified through global targeted literature review in MEDLINE (March 2023). Health utilities and QALYs converted decrements per...

Bone metastases are common in patients with hormone-refractory prostate cancer. In a study of autopsies cancer, 65%-75% had bone metastases. place substantial economic burden on payers estimated total annual costs $1.9 billion the United States. Skeletal-related events (SREs), including pathologic fractures, spinal cord compression, surgery to bone, and radiation affect approximately 50% They associated decreased quality life increased health care costs. Zoledronic acid is an effective...

To gather preliminary data on how the three major types of emergency medicine (EM) providers, physicians, nurses (RNs), and out-of-hospital personnel (EMTs), differ in error identification, disclosure, reporting.A convenience sample department (ED) providers completed a brief survey designed to evaluate frequency, reporting practices as well error-based discussion educational activities.One hundred sixteen subjects participated: 41 EMTs (35%), 33 RNs (28%), 42 physicians (36%). Forty-five...

ABSTRACT Objectives To illustrate a matching‐adjusted indirect comparison by comparing the efficacy of guanfacine extended release (GXR) and atomoxetine (ATX) in reducing oppositional symptoms children with attention‐deficit/hyperactivity disorder comorbid defiant disorder. Methods Individual patient data were used from GXR trial; only published summary ATX trials. In comparison, individual patients trial weighted such that their mean baseline characteristics matched those for Placebo‐arm...

Obstructive hypertrophic cardiomyopathy (oHCM) is a disease of the cardiomyocyte in which dynamic left ventricular outflow track obstruction may lead to heart failure, valvular disease, and sudden death. Little known about healthcare resource utilization (HRU) costs associated with oHCM. This study investigated clinical economic burden oHCM patients or without symptoms oHCM.We used US IBM MarketScan Commercial Medicare Supplemental database identify (January 2009-March 2019). Control were...

There is limited evidence on therapies for obstructive hypertrophic cardiomyopathy (HCM), and data regarding treatment patterns cost are scarce. This study assessed economic outcomes in patients with symptomatic HCM.Adults HCM as per design treated pharmacotherapies [beta blockers (BBs), calcium channel (CCBs), BB + CCB, or disopyramide] procedures (septal reduction therapy, heart transplantation, implantable cardioverter-defibrillator, pacemaker implantation) were identified from the IBM®...

No head-to-head clinical trials have been published comparing guanfacine extended release (GXR) and atomoxetine (ATX): two nonstimulants approved for the treatment of attention-deficit/hyperactivity disorder (ADHD). However, other study designs or methods could be used to indirectly compare these medications. Matching-adjusted indirect comparison (MAIC) is a recent methodology that utilizes individual patient data (IPD) from one aggregate another estimate relative efficacy both, providing...

Aims: To assess the real-world clinical burden and healthcare resource utilization (HRU) among patients with chronic hypoparathyroidism, overall by adequately controlled (AC) vs not (NAC) disease, informed guideline-recommended management targets, including biochemistry symptoms. Materials methods: In this retrospective online chart review, endocrinologists in US, Canada, UK, France, Germany, Italy, Spain were randomly selected to review medical charts of adult hypoparathyroidism receiving...

Haemophilia A (HA) is a rare X chromosome-linked bleeding disorder resulting in missing or defective clotting factor VIII (FVIII) and causes large disease burden.As member of World Federation Hemophilia, China seeks to understand the current epidemiology, profile treatment landscape patients with HA through Hemophilia Treatment Center Collaboration Network (HTCCNC).The HTCCNC enabled data collection on from 166 hospitals (2007-2019) across China. The distribution 31 divisions was summarized...