A5069112627- Menopause: Health Impacts and Treatments
- Reproductive Biology and Fertility
- Estrogen and related hormone effects
- Ovarian function and disorders
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Phytoestrogen effects and research
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Reproductive System and Pregnancy
- Sexual Differentiation and Disorders
- Reproductive Health and Technologies
- Menstrual Health and Disorders
- Bone health and osteoporosis research
- Sperm and Testicular Function
- Cancer-related molecular mechanisms research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Prenatal Screening and Diagnostics
- Bone Metabolism and Diseases
- Hormonal and reproductive studies
- Genetic Associations and Epidemiology
- Microbial metabolism and enzyme function
- Cancer Risks and Factors
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Central Party School of the Communist Party of China
2025
Shanxi Medical University
2023-2025
Peking University
2025
Peking University Sixth Hospital
2025
Peking Union Medical College Hospital
2015-2024
Huazhong Agricultural University
2021-2024
Shandong University
2021-2023
Shanghai Pulmonary Hospital
2023
National Clinical Research Center for Digestive Diseases
2023
Objective To evaluate the efficacy and safety of fezolinetant for moderate to severe vasomotor symptoms (VMS) associated with menopause in East Asian women. Methods In this phase 3, randomized, double-blind study, postmenopausal women VMS (minimum average frequency 10 days before randomization, ≥7/day or 50/week) received 30 mg/day placebo (weeks 1–12), followed by an open-label extension 13–24). The co-primary endpoints were mean changes daily severity at weeks 4 12. Results Among 301...
Abstract Objective Researchers have revealed the combined functions of long noncoding RNAs (lncRNAs) and microRNA (miRNAs) in polycystic ovary syndrome (PCOS). This study aimed to understand role nuclear-enriched abundant transcript 1 (NEAT1) miR-381 involving insulin-like growth factor (IGF1) PCOS. Methods PCOS rat model was established by dehydroepiandrosterone induction. NEAT1, IGF1 expression ovarian granulosa cells patients tissues rats were tested. Bioinformatics website dual...
Abstract Objective: To understand prevalence, severity, impact, and treatment of vasomotor symptoms associated with menopause, using cross-sectional survey data. Methods: This online, two-part was conducted in East Asia among women 40-65 years recruited from established online panels (Edelman, Beijing; Hankook Research, Seoul; Rakuten Insight, Taipei) stratified sampling. Part I collected demographics/disease characteristics, including menopausal status symptom severity. Women...
Abstract Objectives Rheumatoid arthritis (RA) is a chronic, destructive autoimmune disorder predominantly targeting the joints, with gut microbiota dysbiosis being intricately associated its progression. The aim of present study was to develop effective early diagnostic methods for RA based on microbiota. Methods A cohort comprising 262 patients and 475 healthy controls (HCs) recruited. Faecal samples were collected from all participants, microbial DNA subsequently extracted. V3-V4 region...
Dienogest is a progestin with demonstrated efficacy in the treatment of endometriosis European women. The objective this study was to evaluate and safety dienogest Chinese women.This 24-week, randomized, double-blind, placebo-controlled multicenter (n = 23) evaluated 2 mg once daily 255 women aged 18-45 years laparoscopically diagnosed an endometriosis-associated pelvic pain (EAPP) score ≥30 mm on 0-100 visual analog scale. primary variable absolute change EAPP from baseline week 24....
Decline in successful conception decreases more rapidly after 38 years of age owing to follicular depletion and decreased oocyte quality. However, limited information is available regarding the underlying mechanism useful treatment. This study aimed evaluate effects growth hormone supplementation on maturation vivo aged young mice determine its effect mitochondrial function. The influence three different doses recombinant human (rhGH) (0.4, 0.8 1.6 mg/kg/day) for 8 weeks before ovarian...
UDP-glucuronyltransferase 1A1 (UGT1A1) is a member of the Phase II metabolic enzyme family and only that can metabolize detoxified bilirubin. Inactivation very low activity UGT1A1 in liver be fatal or lead to lifelong Gilbert's syndrome (GS) Crigler-Najjar (CN). To date, more than one hundred polymorphisms have been discovered. Although most are not fatal, which diseases might associated with polymorphisms? This scientific topic has studied for years, there still many uncertainties. Herein,...
To assess the correlation between clinical and biochemical hyperandrogenism parameters in polycystic ovary syndrome (PCOS) according to age.This prospective study included 256 PCOS patients diagnosed Rotterdam criteria a university-based hospital. Androgen levels were measured using liquid chromatography-tandem mass spectrometry. Hirsutism, acne, alopecia assessed modified Ferriman-Gallwey (mF-G) score, Comprehensive Acne Severity Scale (CASS), Ludwig scale, respectively. The was younger...
Xiangyan Ruana*, Helen Schneckb*, Silke Schultzb, Tanja Fehmb, Michael A. Cahillc, Harald Seegerb, Rong Chend, Qi Yud, Alfred O. Mueck**b & Hans Neubauerba Beijing Ob/Gyn Hospital, Capital Medical University, Beijing, Chinab University Women's Tübingen, Germanyc School of Biomedical Sciences, Charles Sturt Wagga Wagga, NSW, Australiad Peking Union College China