A5040233864- Estrogen and related hormone effects
- Menopause: Health Impacts and Treatments
- Phytoestrogen effects and research
- Endometrial and Cervical Cancer Treatments
- Cancer Risks and Factors
- Inflammatory mediators and NSAID effects
- Hormonal and reproductive studies
- Reproductive Health and Contraception
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Renal Diseases and Glomerulopathies
- Pregnancy-related medical research
- Prion Diseases and Protein Misfolding
- Breast Cancer Treatment Studies
- Bone health and treatments
- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Nitric Oxide and Endothelin Effects
- Antioxidant Activity and Oxidative Stress
- HER2/EGFR in Cancer Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal Transplantation Outcomes and Treatments
- Kidney Stones and Urolithiasis Treatments
- Glutathione Transferases and Polymorphisms
- Endometriosis Research and Treatment
University Hospital of Zurich
2016-2025
Kantonsspital Baden
2024-2025
University of Zurich
2005-2023
University Hospital of Geneva
2023
Institut für Frauengesundheit
2012-2019
Universitätsklinikum Tübingen
2017-2019
University of Tübingen
2009-2018
University Children's Hospital Tübingen
2008-2018
Swiss Integrative Center for Human Health
2015-2018
Olgahospital
2013-2017
Primary membranous nephropathy (pMN) is a leading cause of nephrotic syndrome in adults. In most cases, this autoimmune kidney disease associated with autoantibodies against the M-type phospholipase A2 receptor (PLA2R1) expressed on podocytes, but mechanisms to glomerular damage remain elusive. Here, we developed cell culture model using human podocytes and found that anti-PLA2R1–positive pMN patient sera or isolated IgG4, not IgG4-depleted sera, induced proteolysis 2 essential podocyte...
Prions typically accumulate in nervous and lymphoid tissues. Because proinflammatory cytokines immune cells are required for prion replication, we tested whether inflammatory conditions affect pathogenesis. We administered prions to mice with five diseases of the kidney, pancreas, or liver. In all cases, chronic lymphocytic inflammation enabled accumulation otherwise prion-free organs. Inflammatory foci consistently correlated lymphotoxin up-regulation ectopic induction FDC-M1 + expressing...
Prion infectivity is typically restricted to the central nervous and lymphatic systems of infected hosts, but chronic inflammation can expand distribution prions. We tested whether inflammatory kidney disorders would trigger excretion prion into urine. Urinary proteins from scrapie-infected mice with lymphocytic nephritis induced scrapie upon inoculation noninfected indicator mice. Prionuria was found in presymptomatic sick mice, whereas neither prionuria nor urinary PrP(Sc) detectable...
Breast cancer is a clinically heterogeneous disease, which necessitates variety of treatments and leads to different outcomes. As an example, only some women will benefit from chemotherapy. Identifying patients who respond chemotherapy thereby improve their long‐term survival has important implications treatment protocols outcomes, while identifying non responders may enable these avail themselves other investigational approaches or potentially effective treatments. In this study, serum...
Renal ischemia-reperfusion (I/R) injury is a major cause of AKI. Noncoding RNAs are intricately involved in the pathophysiology this form Transcription hypoxia-induced, long noncoding RNA H19, which shows high embryonic expression and silenced adults, upregulated renal I/R injury.Lentivirus-mediated overexpression, as well antisense oligonucleotide-based silencing, modulated H19 vitro. In vivo analyses used constitutive knockout mice. addition, vein injection adeno-associated virus 2 (AAV2)...
Background and objectives In patients with kidney failure due to IgA nephropathy, deposits can recur in a subsequent transplant. The incidence, effect, risk factors of nephropathy recurrence is unclear, because most studies have been single center sample sizes are relatively small. Design, setting, participants, & measurements We performed multicenter, international, retrospective study determine the factors, treatment response recurrent after transplantation. Data were collected from...
Combination of a statin plus estrogen may reveal benefits on the cardiovascular system in postmenopausal women by additively ameliorating both lipid profile and vascular function. Long-term therapy with estrogens, however, is associated an increase breast cancer risk. In contrast, evidence accumulating that statins inhibit carcinogenesis because their central action important cellular functions. It special clinical interest whether statin/estrogen combination reduce most undesired side...
Renal ischemia-reperfusion (I/R) injury is a major cause of acute kidney (AKI). Non-coding RNAs are crucially involved in its pathophysiology. We identified hypoxia-induced long non-coding RNA Malat1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) to be upregulated renal I/R injury. here elucidated the functional role vitro and potential contribution vivo. was biopsies plasma patients with AKI, murine hypoxic tissue as well cultured ex vivo sorted endothelial cells tubular...
IntroductionCircular RNAs (circRNAs) have recently been described as novel noncoding regulators of gene expression. They might an impact on microRNA expression by their sponging activity. The detectability in blood these RNA transcripts has demonstrated patients with cancer and cardiovascular disease. We tested the hypothesis that circulating circRNAs critically ill acute kidney injury (AKI) at inception renal replacement therapy may also be dysregulated associated patient survival.MethodsWe...
Circular RNAs (circRNAs) have recently been described as novel noncoding regulators of gene expression. They are detectable in the blood patients with acute kidney injury. We tested whether circRNAs were present urine and could serve new predictors outcome renal transplant rejection.A global circRNA expression analysis using RNA from T cell-mediated allograft rejection control was performed. Dysregulated confirmed a cohort 62 rejection, 10 after successful antirejection therapy, 18 without...
Background Prion diseases are a group of invariably fatal neurodegenerative disorders affecting humans and wide range mammals. An essential part the infectious agent, termed prion, is composed an abnormal isoform (PrPSc) host-encoded normal cellular protein (PrPC). The conversion PrPC to PrPSc thought play crucial role in development prion leads deposition, mainly central nervous system. Sporadic Creutzfeldt–Jakob disease (sCJD), most common form human disease, presents with marked clinical...
The effect of five statins, i.e. atorvastatin, fluvastatin, lovastatin, pravastatin and simvastatin was investigated on the proliferation human breast cancer cell line MCF-7. All statins except were able to inhibit up 90 % at a concentration 50 micro M. Between effective no significant difference observed indicating class-specific effect. These data suggest that may have clinical significance in primary prevention beyond their cholesterol-lowering However, proof must be awaited before...
Abstract Introduction Isolated disseminated tumour cells (DTC) are regarded as surrogate markers for minimal residual disease in breast cancer. Characterisation of these could help understand the known limitations adjuvant therapy. Of particular interest is their oestrogen-receptor (ER) status because endocrine therapy remains a cornerstone cancer treatment. Methods Bone marrow (BM) aspirates from 254 patients with primary were included this study. A double immunofluorescence staining...
Abstract Background Breast cancer belongs to the most frequent and severe types in human. Since excretion of modified nucleosides from increased RNA metabolism has been proposed as a potential target pathogenesis breast cancer, aim present study was elucidate predictability by means urinary excreted nucleosides. Methods We analyzed urine samples 85 women respective healthy controls assess metabolic profiles comprehensive bioinformatic approach. All included nucleosides/ribosylated...
Expression of progesterone receptor membrane component 1 (PGRMC1) has been shown to be higher in breast cancer than normal tissue. We have previously that certain progestogens strongly stimulate proliferation cells overexpressing PGRMC1, and therefore hypothesize PGRMC1 may play a critical role progression. Because little information is available if expression also associated with worse prognosis for patients, this study we investigated the clinicopathologic significance tissue.Expression...
Objective: Our and other studies have pointed on an important role of progesterone receptor membrane component 1 (PGRMC1) in development breast cancer, especially hormone therapy. To investigate if PGRMC1 could be used to predict the risk for getting we assessed tissues patients with primary invasive expression may associated estrogen alpha (ERα), (PR), ki67.Methods: Samples from 109 cancer between years 2008 2014 were obtained patients' consent. Each sample was evaluated ERα, PR, Ki67, by...
Numerous cases of glomerulonephritis manifesting shortly after SARS-CoV-2 vaccination have been reported, but causality remains unproven. Here, we studied the association between mRNA-based and new-onset using a nationwide retrospective cohort case-cohort design. Data from all Swiss pathology institutes processing native kidney biopsies served to calculate incidence IgA nephropathy, pauci-immune necrotizing glomerulonephritis, minimal change disease, membranous nephropathy in adult...