A5089325080- Renal Transplantation Outcomes and Treatments
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Renal Diseases and Glomerulopathies
- Food Allergy and Anaphylaxis Research
- Cytomegalovirus and herpesvirus research
- Organ Transplantation Techniques and Outcomes
- Dialysis and Renal Disease Management
- Renal and Vascular Pathologies
- Blood groups and transfusion
- Complement system in diseases
- Contact Dermatitis and Allergies
- Liver Disease and Transplantation
- CAR-T cell therapy research
- Liver Disease Diagnosis and Treatment
- Electrolyte and hormonal disorders
- GDF15 and Related Biomarkers
- Organ Donation and Transplantation
- Monoclonal and Polyclonal Antibodies Research
- Nutrition and Health in Aging
- Asthma and respiratory diseases
- Mycobacterium research and diagnosis
- Polyomavirus and related diseases
- Heart Failure Treatment and Management
- CNS Lymphoma Diagnosis and Treatment
University of Lucerne
2024-2025
University of Zurich
2011-2025
University Hospital of Zurich
2014-2024
Luzerner Kantonsspital
2024
See-Spital
2017
Klinik und Poliklinik für Neurologie
2015
Background and objectives In patients with kidney failure due to IgA nephropathy, deposits can recur in a subsequent transplant. The incidence, effect, risk factors of nephropathy recurrence is unclear, because most studies have been single center sample sizes are relatively small. Design, setting, participants, & measurements We performed multicenter, international, retrospective study determine the factors, treatment response recurrent after transplantation. Data were collected from...
Background. Biopsy-based transcripts associated with antibody-mediated rejection (AMR) hold promise as substitutes for C4d positivity. However, their utility in cases additional diagnoses other than remains inadequately studied. Methods. In our comprehensive analysis of 326 kidney allograft biopsies, assessed by histology and the Molecular Microscope Diagnostic System, we identified 68 characterized pathologies, including pyelonephritis (n = 15), BK nephropathy 20), acute interstitial...
Membranous nephropathy (MN) is a leading cause of kidney failure worldwide, and frequently recurs after transplant. Available data originated from small retrospective cohort studies or registry analyses. Therefore, uncertainties remain on risk factors for MN recurrence response to therapy. Within the Post-Transplant Glomerular Disease (TANGO) Consortium, we conducted multicenter study examining rate, factors, treatment. This screened 22,921 patients across three continents included 194 who...
Isolated Tubulitis, Borderline Changes, and Arteritis suspicious for histologic T cell-mediated rejection (hTCMR) remain findings of uncertain significance. Although the Molecular Microscope Diagnostics System (MMDx) has not been trained on those lesions, it was suggested that MMDx might reclassify a subgroup to molecular TCMR (mTCMR).
Indication biopsies for deterioration of kidney allograft function often require follow-up to assess treatment response or lack improvement. Immune-mediated injury, namely borderline rejection (BLR), T-cell mediated (TCMR), antibody-mediated (ABMR), results from preformed de novo alloreactivity due donor and recipient HLA-mismatches. The impact HLA-mismatches on is determined by highly immunogenic HLA-epitopes.We analyzed 123 transplant recipients (KTRs) 2009 2019 who underwent a first...
Background. The Molecular Microscope Diagnostic System (MMDx) may overcome histology shortcomings. Previous studies have simply examined discrepant findings but not attempted to determine clinical endpoints. To measure performance, outcomes are strongly required. Methods. This single-center cohort study described discrepancies between MMDx and from 51 kidney transplant recipients (KTRs) analyzed 72 indication biopsies, including 21 follow-up biopsies. Clinical performance was assessed by a...
Epicutaneous immunotherapy targets the network of dendritic cells in epidermis. Allergen exposure dermal layers should be limited as these contain mast and blood vessels, which increases risk for local systemic allergic reactions.This intraindividually controlled trial included 20 subjects with birch pollen allergy. Three areas volar forearms were treated by repeated adhesive-tape stripping, single-prick lancet piercing microneedle array application. Four 10-fold dilutions allergen extract...
ABSTRACT Introduction Previous studies show heterogeneity when applying estimated glomerular filtration (eGFR) equations to kidney transplant recipients (KTRs). However, research on the impact of transplantation-related characteristics eGFR using creatinine (eGFRcr) compared cystatin C (eGFRcys) is scarce. Methods We conducted a comprehensive analysis with three eGFRcr (Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2009, European Function Consortium (EKFC) 2021, recipient...
<b><i>Background:</i></b> Venom immunotherapy is highly efficacious in preventing anaphylactic sting reactions. However, there an ongoing discussion regarding patient selection and whether how to apply a cost-benefit analysis of venom immunotherapy. In order help decision-making, we investigated the re-sting frequency hymenoptera-venom-allergic patients single out those at high risk. <b><i>Methods:</i></b> this retrospective study, data 96...
Accurate volume status evaluation and differentiation of cardiac non-cardiac components overhydration (OH) are fundaments optimal haemodialysis (HD) management.This study, by combining bioimpedance measurements, cardiovascular biomarkers echocardiography, aimed at dissecting OH into its major functional components, prospectively tested the association between with mortality. In first part, we validated soluble CD146 (sCD146) as a biomarker systemic congestion in cohort 30 HD patients. second...
Cancer risk is increased by 2- to 4-fold in kidney transplant recipients (KTRs) compared with the general population. Little attention, however, has been given KTRs ultra long-term survival >20 years.We studied 293 of 1241 (23.6%), transplanted between 1981 and 1999, who showed allograft years. These survivors were analysed for cancer development, type, cancer-associated factors patient outcomes.By 10, 20 30 years post-transplantation, these a rate 4.4%, 14.6% 33.2%, non-melanoma skin (NMSC)...
We present the successful treatment of a patient with post-transplant lymphoproliferative disorder (PTLD) central nervous system (CNS) checkpoint inhibition, followed by infusion chimeric antigen receptor T cells (CAR-T). CD19-directed CAR-T are an effective option for patients relapsed/refractory (r/r) aggressive B-cell lymphoma. Although some first experience use in CNS lymphoma has been published, reports on PTLD scarce. In addition to our case, we provide review available literature and...
Letermovir (LTV) might be an alternative treatment to nephrotoxic foscarnet (FOS) in Ganciclovir (GCV) resistant cytomegalovirus (CMV) infection. However, its efficacy controlling active CMV viremia is unclear, as it only approved for prophylaxis hematopoietic stem-cell transplantation.This case series describes 14 kidney transplant recipients (KTR) with moderate-level GCV infection, treated by different step-down strategies after initial FOS therapy: (1) Observation without antiviral...
Older age at organ transplantation is associated with increased risk of infection and malignancy but reduced cellular rejection. De novo donor-specific anti-HLA antibodies (dnDSA), are key biomarkers long-term allograft survival, yet there a lack data focusing on age-associated changes.Development dnDSA was restrospectively analyzed in all subjects who received kidney transplant the University Hospital Zurich between 01/2006 02/2015. Follow up continued until 03/2016. The incidence different...
Abstract Background Epicutaneous vaccination has gained increasing interest during the past decade as it offers a safe, needle‐free, and patient‐friendly alternative to invasive vaccine administrations. Recently, safety early efficacy of epicutaneous immunotherapy were also demonstrated in patients with hay fever, an conventional subcutaneous allergen‐specific ( SCIT ). One major challenge is barrier function stratum corneum , which must be overcome either by abrasive methods or hydration....