A5015826182- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Organ Donation and Transplantation
- Renal Diseases and Glomerulopathies
- Organ Transplantation Techniques and Outcomes
- Renal and Vascular Pathologies
- Parathyroid Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Complement system in diseases
- Renal and related cancers
- Acute Kidney Injury Research
- Pharmacological Effects and Toxicity Studies
- Liver Disease and Transplantation
- Metabolism and Genetic Disorders
- Genetic and Kidney Cyst Diseases
- Central Venous Catheters and Hemodialysis
- Transplantation: Methods and Outcomes
- COVID-19 Clinical Research Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Vitamin D Research Studies
- Renal cell carcinoma treatment
- Diabetes Treatment and Management
- Immune Cell Function and Interaction
- Electrolyte and hormonal disorders
- Bone health and treatments
University of Bologna
2016-2025
Azienda USL di Bologna
2017-2025
Società Italiana di Nefrologia
2019-2024
Policlinico S.Orsola-Malpighi
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
Zambon (Italy)
2024
Research Centre for Cereal and Industrial Crops
2023
Puigvert Foundation
2023
Université Paris Cité
2023
Institute Mutualiste Montsouris
2023
Ravulizumab is a long-acting C5 inhibitor engineered from eculizumab with increased elimination half-life, allowing an extended dosing interval two to eight weeks. Here we evaluate the efficacy and safety of ravulizumab in adults atypical hemolytic uremic syndrome presenting thrombotic microangiopathy. In this global, phase 3, single arm study complement inhibitor-naïve (18 years older) who fulfilled diagnostic criteria for syndrome, enrolled patients received through 26-week initial...
Background and objectives FSGS recurrence after kidney transplantation is a major risk factor for graft loss. However, the natural history, clinical predictors, response to treatment remain unclear because of small sample sizes poor generalizability single-center studies, disease misclassification in registry-based studies. We therefore aimed determine incidence, recurrent large cohort transplant recipients. Design, setting, participants, & measurements The Post-Transplant Glomerular...
Renin–angiotensin–aldosterone system (RAAS) inhibitors are standard care in patients with hypertension, heart failure or chronic kidney disease (CKD). Although we have studied the RAAS for decades, there still circumstances that remain unclear. In this review, describe evolution of and pose question whether survival trait is necessary to humankind present age. We elucidate benefits on cardiovascular health inhibition promising novel medications. Furthermore, address why more studies needed...
The kidney exerts multiple functions, and pathophysiological interactions between the heart have important clinical implications, but it has only recently become clear that these should be studied across whole spectrum of reduced function not in cases with severe, end-stage renal disease (ESRD), as been done for many years.1 prevalence chronic (CKD), defined a glomerular filtration rate (GFR) 3 months, exceeds 10% adult population reaches 47% subjects older than 70 years, according to data...
Restless legs syndrome (RLS) is a sensorimotor neurological disorder characterized by paraesthesia, dysaesthesia and the irresistible urge to move especially at night. Its prevalence much higher among dialysis patients 12 62% compared 3 9% in general population. Here, we investigated association between RLS cardiovascular events risk laboratory parameters end-stage kidney disease (ESKD) on dialysis.One hundred ESKD undergoing haemodialysis were enrolled an 18-month prospective observational...
Kidney glomerulosclerosis commonly progresses to end-stage kidney failure, but pathogenic mechanisms are still poorly understood. Here, we show that podocyte expression of decay-accelerating factor (DAF/CD55), a complement C3 convertase regulator, crucially controls disease in murine models adriamycin (ADR)-induced focal and segmental (FSGS) streptozotocin (STZ)-induced diabetic glomerulosclerosis. ADR induces enzymatic cleavage DAF from surfaces, leading activation. deficiency or prevention...
IntroductionPost-transplant thrombotic microangiopathy (PT-TMA) is an uncommon event that characterizes approximately 3-14% of kidney transplants (KT), and associated with a higher risk delayed graft function loss. PT-TMA occurs more frequently within the first three months after transplant can be manifestation de novo disease or recurrence previous atypical hemolytic uremic syndrome (aHUS). Abnormalities in complement regulation genes could explain increased susceptibility some patients to...
Objectives To evaluate and compare the correlations between Preoperative Aspects Dimensions Used for an Anatomical ( PADUA ) R.E.N.A.L. [Radius (tumour size as maximal diameter), Exophytic/endophytic properties of tumour, Nearness tumour deepest portion to collecting system or sinus, Anterior (a)/posterior (p) descriptor Location relative polar line] nephrometry scores perioperative outcomes postoperative complications in a multicentre, international series patients undergoing robot‐assisted...
Hypoxia plays an important role in limiting the engraftment, survival, and function of intrahepatically transplanted islets. Mesenchymal stem cells (MSCs) were recently used animal models islet transplantation not only to reduce allograft rejection but also promote revascularization. Among different possible origins, adipose tissue represents a novel good source MSCs. Moreover, capability tissue-derived (ASCs) improve graft revascularization was reported after hybrid mice. Within this...
Abstract With the aim to explore innovative tools for organ preservation, especially in marginal organs, we hereby describe a clinical trial of ex-vivo hypothermic oxygenated perfusion (HOPE) field liver (LT) and kidney transplantation (KT) from Extended Criteria Donors (ECD) after brain death. A matched-case analysis donor recipient variables was developed: 10 HOPE-ECD livers kidneys (HOPE-L HOPE-K) were matched 1:3 with preserved static cold storage (SCS-L SCS-K). HOPE SCS groups resulted...
Individuals with kidney failure are at increased risk of cardiovascular events, as well infections and malignancies, but the associated immunological abnormalities unclear. We hypothesized that uremic milieu triggers a chronic inflammatory state that, while accelerating atherosclerosis, promotes T cell exhaustion, impairing effective clearance pathogens tumor cells. Clinical demographic data were collected from 78 patients disease (CKD) (
Background and objectives In patients with kidney failure due to IgA nephropathy, deposits can recur in a subsequent transplant. The incidence, effect, risk factors of nephropathy recurrence is unclear, because most studies have been single center sample sizes are relatively small. Design, setting, participants, & measurements We performed multicenter, international, retrospective study determine the factors, treatment response recurrent after transplantation. Data were collected from...