A5068810672- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Renal and Vascular Pathologies
- COVID-19 Clinical Research Studies
- Nutrition and Health in Aging
- Bone health and treatments
- Parathyroid Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Frailty in Older Adults
- Neurological Complications and Syndromes
- Immune Cell Function and Interaction
- Vasculitis and related conditions
- Bone health and osteoporosis research
- Medical Imaging and Pathology Studies
- Long-Term Effects of COVID-19
- Blood groups and transfusion
- Complement system in diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Polyomavirus and related diseases
- Pregnancy and Medication Impact
- Chronic Kidney Disease and Diabetes
Hospital Del Mar
2015-2024
Hospital del Mar Research Institute
2016-2024
Universitat Pompeu Fabra
2016-2024
Parc de Salut
2015-2024
Universitat de Barcelona
2023
Brigham and Women's Hospital
2018-2022
Harvard University
2018-2022
Municipal Institute for Medical Research
2013-2020
Sociedad Española de Nefrología
2020
Universitat Autònoma de Barcelona
2016-2019
Kidney transplant recipients may be at a high risk of developing critical coronavirus disease 2019 (COVID-19) illness due to chronic immunosuppression and comorbidities. We identified hospitalized adult kidney 12 centers in the United States, Italy, Spain who tested positive for COVID-19. Clinical presentation, laboratory values, immunosuppression, treatment strategies were reviewed, predictors poor clinical outcomes determined through multivariable analyses. Among 9845 across centers, 144...
Background and objectives FSGS recurrence after kidney transplantation is a major risk factor for graft loss. However, the natural history, clinical predictors, response to treatment remain unclear because of small sample sizes poor generalizability single-center studies, disease misclassification in registry-based studies. We therefore aimed determine incidence, recurrent large cohort transplant recipients. Design, setting, participants, & measurements The Post-Transplant Glomerular...
Acute respiratory distress syndrome associated with coronavirus infection is related to a cytokine storm large interleukin-6 (IL-6) release. The IL-6-receptor blocker tocilizumab may control the aberrant host immune response in patients disease 2019 (COVID-19) . In this pandemic, kidney transplant (KT) recipients are high-risk population for severe and showed poor outcomes. We present multicenter cohort study of 80 KT COVID-19 treated during hospital admission. High mortality rate was...
The SARS-Cov-2 infection disease (COVID-19) pandemic has posed at risk the kidney transplant (KT) population, particularly elderly recipients. From March 12 until April 4, 2020, we diagnosed COVID-19 in 16 of our 324 KT patients aged ≥65 years old (4.9%). Many them had contact with healthcare facilities month prior to infection. Median time symptom onset admission was 7 days. All presented fever and all but one pneumonia. Up 33% showed renal graft dysfunction. At diagnosis, mTOR inhibitors...
Patients with end-stage renal disease have longer survival after kidney transplantation than they would by remaining on dialysis; however, outcome kidneys from donors aged ≥75 years and the of recipients these organs compared their dialysis counterparts same probability obtaining an organ is unknown. In a longitudinal mortality study, 2040 patients were placed waiting list, 389 them received first transplant deceased donor years. The adjusted risk death calculated non-proportional hazards...
The prognostic factors and optimal therapy for invasive pulmonary aspergillosis (IPA) after kidney transplantation (KT) remain poorly studied. We included in this multinational retrospective study 112 recipients diagnosed with probable (75.0% of cases) or proven (25.0%) IPA between 2000 2013. median interval from to diagnosis was 230 days. Cough, fever, expectoration were the most common symptoms at presentation. Bilateral involvement observed 63.6% cases. Positivity rates galactomannan...
Bisphosphonates are the first-line treatment for preventing fractures in osteoporosis patients. However, their use is contraindicated or to be used with caution chronic kidney disease (CKD) patients, primarily because of a lack information about safety and effectiveness. We aimed investigate oral bisphosphonates patients moderate severe CKD, using primary-care electronic records from two cohorts, CPRD GOLD (1997-2016) SIDIAP (2007-2015) UK Catalonia, respectively. Both databases were linked...
Background and objectives In patients with kidney failure due to IgA nephropathy, deposits can recur in a subsequent transplant. The incidence, effect, risk factors of nephropathy recurrence is unclear, because most studies have been single center sample sizes are relatively small. Design, setting, participants, & measurements We performed multicenter, international, retrospective study determine the factors, treatment response recurrent after transplantation. Data were collected from...
Studies are urgently needed to characterize immunogenicity, efficacy, and safety of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines in kidney transplant (KT) recipients, excluded from major clinical trials. Complex ELISPOT other cellular response techniques have been applied, but simpler tools needed. An easy-to-use real-world monitoring SARS-CoV-2 IgG antibodies against the Spike protein QuantiFERON® IFNγ release assay (IGRA) were performed at baseline 28 days...
Correlation between antibody-mediated rejection (ABMR) and circulating HLA donor-specific antibodies (HLA-DSA) is strong but imperfect in kidney transplant (KT) recipients, raising the possibility of undetected HLA-DSA or non-HLA contributing to ABMR. Detailed evaluation degree matching together with identification KT may help decipher antibody involved.
Abstract CMV infection in kidney transplant recipients (KTRs) has been associated with an increased risk for graft loss and reduced host survival. promotes persistent expansions of NK cells expressing the CD94/NKG2C receptor. The NKG2C (KLRC2) gene is frequently deleted, copy number influences adaptive response NKG2C+ cells. distribution genotypes (NKG2C+/+, NKG2C+/del, NKG2Cdel/del) were studied cross-sectional (n = 253) prospective 122) KTR cohorts. Assessment viremia was restricted to...
BackgroundKidney recipients maintaining a prolonged allograft survival in the absence of immunosuppressive drugs and without evidence rejection are supposed to be exceptional. The ERA-EDTA-DESCARTES working group together with Nantes University launched European-wide survey identify new patients, describe them estimate their frequency for first time.
Background. Patient survival with end-stage renal disease is longer after kidney transplantation (KT) compared those remaining on dialysis. Nevertheless, this remains uncertain when receiving a from donor ≥80 years old. Methods. In longitudinal mortality study in the Catalan Renal Registry including 2585 patients ≥60 old dialysis and placed KT waiting list, 1084 received first deceased aged 60 to 79 128 years. We calculated adjusted risk of graft loss by means competing-risks regression,...
Remdesivir has demonstrated antiviral activity against coronavirus, shortening the time to recovery in adults hospitalized with moderate/severe COVID-19. Severe adverse events such as acute kidney injury have been reported. Scant data are available on use and safety of remdesivir transplant recipients.We present a multicenter cohort study 51 recipients COVID-19 treated remdesivir. Outcomes were assessed.Mean age at diagnosis was 60 years, median since 4.5 years. Mean admission 2 days....
Isolated microvascular inflammation (iMVI) without HLA donor-specific antibodies or C4d deposition in peritubular capillaries remains an enigmatic phenotype that cannot be categorized as antibody-mediated rejection (ABMR) recent Banff classifications. We included 221 kidney transplant recipients with biopsies ABMR (n = 73), iMVI 32), and normal 116) diagnoses. compared peripheral blood leukocyte distribution by flow cytometry inflammatory infiltrates among groups. Flow showed fewer...
Detection of posttransplant donor-specific anti-HLA antibodies (DSA) constitutes a risk factor for kidney allograft loss. Together with complement activation, NK-cell antibody-dependent cell mediated cytotoxicity (ADCC) has been proposed to contribute the microvascular damage associated humoral rejection. In present observational exploratory study, we have tried find relationship circulating and non (DSA HLA non-DSA) peripheral blood subsets clinical features in 393 renal recipients....
Risk factors for invasive pulmonary aspergillosis (IPA) after kidney transplantation have been poorly explored. We performed a multinational case-control study that included 51 transplant (KT) recipients diagnosed with early (first 180 posttransplant days) IPA at 19 institutions between 2000 and 2013. Control were matched (1:1 ratio) by center date of transplantation. Overall mortality among cases was 60.8%, 25.0% living experienced graft loss. Pretransplant diagnosis chronic obstructive...
Significance Statement Sustained (or overt) diabetes mellitus after kidney transplantation is strongly associated with hyperglycemia during the early perioperative period. In a multicenter trial 263 participants randomized to strict blood glucose monitoring and an basal insulin intervention versus control (a more liberal approach consisting of sporadic corrections otherwise oral antidiabetics), overt post-transplantation (PTDM) was ascertained by antidiabetic treatment tolerance test (2 hour...