A5010969398- Bone health and osteoporosis research
- Bone health and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Parathyroid Disorders and Treatments
- Hip and Femur Fractures
- Rheumatoid Arthritis Research and Therapies
- Bariatric Surgery and Outcomes
- Frailty in Older Adults
- Medical Imaging and Pathology Studies
- Nutrition and Health in Aging
- Ear Surgery and Otitis Media
- Folate and B Vitamins Research
- Tuberculosis Research and Epidemiology
- Total Knee Arthroplasty Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Bone fractures and treatments
- Respiratory and Cough-Related Research
- Clinical practice guidelines implementation
- Sinusitis and nasal conditions
- Bone and Joint Diseases
- Orthopaedic implants and arthroplasty
- Musculoskeletal pain and rehabilitation
- Mycobacterium research and diagnosis
- Dialysis and Renal Disease Management
Nuffield Orthopaedic Centre
2019-2024
University of Oxford
2019-2024
University of Alabama at Birmingham
2024
Amazon (United States)
2024
National Institute for Health Research
2021
Advisory Board Company (United States)
2021
CHR Verviers
2021
Office for National Statistics
2020
Oxford BioMedica (United Kingdom)
2019
University of Manchester
2016-2018
OBJECTIVE--To examine the efficacy and safety of conservative management mild otitis media ("the acute red ear") in children. DESIGN--Double blind placebo controlled trial. SETTING--17 group general practices (48 practitioners) Southampton, Bristol, Portsmouth. PATIENTS--232 children aged 3-10 years with earache at least one abnormal eardrum (114 allocated to receive antibiotic, 118 placebo). INTERVENTIONS--Amoxycillin 125 mg three times a day for seven days or matching placebo; 100 ml...
Otitis media with effusion (OME) is both extremely common in young children, and variable its duration severity. This study aims to gather consider new reliable information about the incidence prevalence of OME British school children. Eight hundred fifty-six children aged five eight years from four South West Hampshire schools were examined over a three-year period by tympanometry, method used detect (> 90 per cent specificity sensitivity) performed once term. Normal ears recorded 54.9...
Bisphosphonates are the first-line treatment for preventing fractures in osteoporosis patients. However, their use is contraindicated or to be used with caution chronic kidney disease (CKD) patients, primarily because of a lack information about safety and effectiveness. We aimed investigate oral bisphosphonates patients moderate severe CKD, using primary-care electronic records from two cohorts, CPRD GOLD (1997-2016) SIDIAP (2007-2015) UK Catalonia, respectively. Both databases were linked...
<title>Abstract</title> As our climate undergoes significant shifts, both the Earth and human societies are increasingly exposed to disasters stress. This situation underscores critical need for robust Early Warning Systems (EWS), which intricately designed monitor, assess, relay information about impending risks hazards. EWS vital in promoting resilient sustainable development, yet they encounter substantial challenges forecasting hazards impacts, communicating risks, efficiency of...
To explore clustering of comorbidities among patients with a new diagnosis OA and estimate the 10-year mortality risk for each identified cluster.This is population-based cohort study individuals first incident hip, knee, ankle/foot, wrist/hand or 'unspecified' site between 2006 2020, using SIDIAP (a primary care database representative Catalonia, Spain). At time diagnosis, conditions associated in literature that were found ≥1% (n = 35) fitted into two cluster algorithms, k-means latent...
SUMMARY Cryptosporidium has become increasingly recognized as a pathogen responsible for outbreaks of diarrhoeal illness in both immunocompetent and immunocompromised persons. In August 2001, an Illinois hospital reported cryptosporidiosis cluster potentially linked to local waterpark. There were 358 case-patients identified. We conducted community-based waterpark-based case-control studies examine potential sources the outbreak. collected stool specimens from ill persons pool water samples...
Abstract Dupuytren’s disease (DD) is a common fibro-proliferative disorder of the palm. We estimated risk serious local and systemic complications re-operation after DD surgery. queried England’s Hospital Episode Statistics database included all adult patients who were surgically treated. A longitudinal cohort study self-controlled case series conducted. Between 1 April 2007 31 March 2017, 121,488 adults underwent 158,119 operations for DD. The cumulative incidence 90-day was low at 1.2%...
The epidemiology and pathogenesis of fractures in postmenopausal women has previously been investigated the Global Longitudinal study Osteoporosis Women (GLOW). To date, however, relationships between bone imaging outcomes fracture have not studied this cohort. We examined high-resolution peripheral quantitative computed tomography (HRpQCT) parameters UK arm GLOW, performing a cluster analysis to assess if our findings were similar observations reported from older participants Hertfordshire...
While several definitions exist for multimorbidity, frailty or polypharmacy, it is yet unclear to what extent single healthcare markers capture the complexity of health-related needs in older people community. We aimed identify and characterise with complex health based on resource use (unplanned hospitalisations polypharmacy) using large population-based linked records.In this cohort study, data was extracted from UK primary care records (CPRD GOLD), Hospital Episode Statistics inpatient...
We studied the characteristics of patients prescribed osteoporosis medication and patterns use in European databases. Patients were mostly female, older, had hypertension. There was suboptimal persistence particularly for oral medications. Our findings would be useful to healthcare providers focus their resources on improving specific treatments.To characterise therapy describe drug utilization patterns.We investigated treatment bisphosphonates, denosumab, teriparatide, selective estrogen...
To evaluate the effects of different definitions glucocorticoid (GC) exposure on magnitude and pattern fracture risk using same dataset. Data from patients with rheumatoid arthritis (RA) were extracted Clinical Practice Research Datalink, a primary care database electronic health records in United Kingdom. Patients exposed to oral GCs matched up two unexposed by age, gender location. The first osteoporotic was identified adjusted unadjusted cox proportional hazard ratios (HR) 95% confidence...
Introduction Osteoarthritis (OA) is one of the leading chronic conditions in older population. People with OA are more likely to have or other than those without. However, temporal associations, clusters comorbidities, role analgesics and causality variation between populations yet be investigated. This paper describes protocol a multinational study four European countries (UK, Netherlands, Sweden Spain) exploring comorbidities people OA. Methods analysis will investigate (1) associations 61...
What are the associations and risk factors for otitis media with effusion (glue-ear)? A 1 year case control study in 5–7 old children from four south-west Hampshire schools examined some of highlighted by literature. history frequent ear problems over previous year, a earache at any time child's life, bottle feeding, red drum otoscopy new finding night cough all carried an increased relative risk.
Shoulder dislocations are the most common joint seen in emergency departments. Most traumatic cases anterior and cause recurrent dislocations. Management options include surgical conservative treatments. There is a lack of evidence about which method effective after first shoulder dislocation (TASD).To produce UK age- sex-specific incidence rates for TASD. To assess whether or not surgery within 6 months first-time TASD decreases re-dislocation compared with no surgery. identify clinical...
Evidence on health and social care resource utilisation associated costs, how this varies across people with Alzheimer's disease (AD) dementia is limited. Retrospective cohort, using the Discover dataset, which includes linked records for approximately 2.5 million in North-West London. Individuals were followed up from latter of 2010 or diagnosis AD (index) to 2019. Outcomes overall survival, home admission, cardiovascular outcomes. Variation was explored subpopulations by stratifying cost...
Better indicators from affordable, sustainable data sources are needed to monitor population burden of musculoskeletal conditions. We propose five health and assessed if routinely available primary care electronic records (EHR) can estimate levels in consulters.We collected validated patient-reported measures pain experience, function status through a local survey adults (≥35 years) presenting English general practices over 12 months for low back pain, shoulder osteoarthritis other regional...
ABSTRACT Conflicting results exist about the relationship between bariatric surgery and fracture risk. Also, prediction of who is at increased risk after not currently available. Hence, we used a combination self-controlled case series (SCCS) study to establish association fracture, develop model for postoperative estimation using cohort study. Patients from UK Primary care records Clinical Practice Research Datalink GOLD linked Hospital Episode Statistics undergoing with body mass index...
Abstract There is emerging evidence of the impact infections on rheumatoid arthritis pathogenesis and flares. We aimed to study association between antibiotic use (and timing use), occurrence flares in patients with RA. nested a self-controlled case series (SCCS) who have RA within newly diagnosed cohort (n = 31,992) from UK Clinical Practice Research Datalink (CPRD) GOLD dataset. determined associations exposure antibiotics (beta-lactam, imidazole, macrolide, nitrofurantoin, quinolone,...
ABSTRACT Although oral bisphosphonates (BP) are commonly used, there is conflicting evidence for their safety in the elderly. Safety concerns might trump BP use older patients with complex health needs. Our study evaluated of BP, focusing on severe acute kidney injury (AKI), gastrointestinal ulcer (GI ulcer), osteonecrosis jaw (ONJ), and femur fractures. We used UK primary care data (Clinical Practice Research Datalink [CPRD GOLD]), linked to hospital (Hospital Episode Statistics [HES]...
We assessed the risk of adverse events-severe acute kidney injury (AKI), falls and fractures-associated with use antihypertensives in older patients complex health needs (CHN).UK primary care linked to inpatient mortality records.The source population comprised aged >65, ≥1 year registration unexposed before study start. identified three cohorts CHN, namely, unplanned hospitalisations, frailty (electronic index deficit count ≥3) polypharmacy (prescription ≥10 medicines). Patients any these...
A total of 325 eligible paediatric patients were entered into an open, randomised, multicentre general practice study to assess the comparative efficacy a new third-generation oral cephalosporin, cefixime, with respect that amoxycillin in treatment acute otitis media. The dose cefixime was 100 mg once daily (six months five years), 200 (five 10 years) and 300 (10 16 years). as currently used by participating practitioners: 62.5 tds one year), 125 (one seven 250 (seven Both form suspension....
Abstract Objective In PsA, the treatment objective is remission or low disease activity (LDA), but patients’ perception of poorly studied. This analysis aimed to identify factors associated with patient-defined remission. Methods uses ReFlaP data, an international PsA study, defined as ‘At this time, your psoriatic arthritis in remission, if means: you feel good gone?’. Variables with, first, and, second, LDA were identified using multivariable logistic regression and principal component...