Edward Burn
A5089054278- COVID-19 Clinical Research Studies
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Health Systems, Economic Evaluations, Quality of Life
- Rheumatoid Arthritis Research and Therapies
- Orthopedic Infections and Treatments
- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- Platelet Disorders and Treatments
- Chronic Disease Management Strategies
- Global Cancer Incidence and Screening
- Machine Learning in Healthcare
- COVID-19 epidemiological studies
- Peripheral Neuropathies and Disorders
- Healthcare cost, quality, practices
- COVID-19 diagnosis using AI
- Healthcare Policy and Management
- Tuberculosis Research and Epidemiology
- Biosimilars and Bioanalytical Methods
- Chronic Lymphocytic Leukemia Research
- Vaccine Coverage and Hesitancy
University of Oxford
2016-2025
Institut Universitari d'Investigació en Atenció Primària Jordi Gol
2020-2025
Nuffield Orthopaedic Centre
2016-2025
NIHR Oxford Musculoskeletal Biomedical Research Centre
2021-2024
Office for National Statistics
2019-2022
Erasmus MC
2022
Idiap Research Institute
2022
Universitat Autònoma de Barcelona
2022
University Hospitals of Derby and Burton NHS Foundation Trust
2019
Queensland University of Technology
2015-2017
Hydroxychloroquine, a drug commonly used in the treatment of rheumatoid arthritis, has received much negative publicity for adverse events associated with its authorisation emergency use to treat patients COVID-19 pneumonia. We studied safety hydroxychloroquine, alone and combination azithromycin, determine risk routine care arthritis.
Abstract Objective To study the association between covid-19 vaccines, SARS-CoV-2 infection, and risk of immune mediated neurological events. Design Population based historical rate comparison self-controlled case series analysis. Setting Primary care records from United Kingdom, primary Spain linked to hospital data. Participants 8 330 497 people who received at least one dose vaccines ChAdOx1 nCoV-19, BNT162b2, mRNA-1273, or Ad.26.COV2.S rollout vaccination campaigns end data availability...
BackgroundAlthough vaccines have proved effective to prevent severe COVID-19, their effect on preventing long-term symptoms is not yet fully understood. We aimed evaluate the overall of vaccination long COVID and assess comparative effectiveness most used (ChAdOx1 BNT162b2).MethodsWe conducted a staggered cohort study using primary care records from UK (Clinical Practice Research Datalink [CPRD] GOLD AURUM), Catalonia, Spain (Information System for in Primary Care [SIDIAP]), national health...
BackgroundThere are few data on the incidence of thrombosis among COVID-19 cases, with most research concentrated hospitalised patients. We aimed to estimate venous thromboembolism, arterial and death cases assess impact these events risks hospitalisation death.MethodsWe conducted a distributed network cohort study using primary care records from Netherlands, Italy, Spain, UK, outpatient specialist Germany. The Spanish database was linked hospital admissions. Participants were followed up...
ABSTRACT Background Hydroxychloroquine has recently received Emergency Use Authorization by the FDA and is currently prescribed in combination with azithromycin for COVID-19 pneumonia. We studied safety of hydroxychloroquine, alone azithromycin. Methods New user cohort studies were conducted including 16 severe adverse events (SAEs). Rheumatoid arthritis patients aged 18+ initiating hydroxychloroquine compared to those sulfasalazine followed up over 30 days. Self-controlled case series...
To measure changes in length of stay following total knee and hip replacement (TKR THR) between 1997 2014 estimate the impact on hospital reimbursement, all else being equal. Further, to assess degree which observed trends can be explained by improved efficiency or patient profiles.Cross-sectional study using routinely collected data.National Health Service primary care records from 1995 Clinical Practice Research Datalink were linked inpatient data Hospital Episode Statistics Admitted...
Abstract Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use patients. Here, we describe characteristics adults COVID-19 compare them influenza We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) patients, summarising between 4811 11,643 unique aggregate characteristics. patients have been majority male in US Spain, predominantly female...
Objectives To assess the value for money of unicompartmental knee replacement (UKR) compared with total (TKR). Design A lifetime Markov model provided framework analysis. Setting Data from National Joint Registry (NJR) England and Wales primarily informed Participants Propensity score matched patients in NJR who received either a UKR or TKR. Interventions is less invasive alternative to TKR, where only compartment affected by osteoarthritis replaced. Primary outcome measures Incremental...
There is growing interest in using observational data to assess the safety, effectiveness, and cost effectiveness of medical technologies, but operational, technical, methodological challenges limit its more widespread use. Common models federated networks offer a potential solution many these problems. The open-source Observational Medical Outcomes Partnerships (OMOP) common model standardises structure, format, terminologies otherwise disparate datasets, enabling execution analytical code...
Abstract Objective To investigate the use of repurposed and adjuvant drugs in patients admitted to hospital with covid-19 across three continents. Design Multinational network cohort study. Setting Hospital electronic health records from United States, Spain, China, nationwide claims data South Korea. Participants 303 264 January 2020 December 2020. Main outcome measures Prescriptions or dispensations any drug on 30 days after date admission for covid-19. Results Of included, 290 131 were...
Abstract The natural history of coronavirus disease 2019 (COVID-19) has yet to be fully described. Here, we use patient-level data from the Information System for Research in Primary Care (SIDIAP) summarise COVID-19 outcomes Catalonia, Spain. We included 5,586,521 individuals general population. Of these, 102,002 had an outpatient diagnosis COVID-19, 16,901 were hospitalised with and 5273 died after either being diagnosed or between 1st March 6th May 2020. Older age, male, having...
For patients with medial compartment arthritis who have failed non-operative treatment, either a total knee arthroplasty (TKA) or unicompartmental (UKA) can be undertaken. This analysis considers how the choice between UKA and TKA affects long-term patient-reported outcome measures (PROMs). The Knee Arthroplasty Trial (KAT) cohort of received minimally invasive provided data. Propensity score matching was used to identify comparable patients. Oxford Score (OKS), its pain function components,...
Abstract In addition to affecting quality of life, diabetic foot ulcers ( DFUs ) impose an economic burden on both patients and the health system. This study developed a Markov model analyse cost‐effectiveness implementing optimal care in comparison with continuation usual for at high risk Australian setting. The results demonstrated overall 5‐year cost savings AUD 9100·11 those aged 35–54, $9391·60 55–74 $12 394·97 75 or older) improved benefits measured quality‐adjusted life years QALYs...
<h3>Objective</h3> To estimate the cost-effectiveness of Tobacco, Exercise and Diet Messages (TEXT ME), a text message-based intervention that provides advice, motivation, information support to improve health-related behaviours. <h3>Methods</h3> A lifetime Markov model was used major vascular events (myocardial infarctions strokes) avoided, quality-adjusted life years (QALYs) gained, costs health system incremental cost per QALY gained. The informed by data from randomised controlled trial...
OBJECTIVES To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children adolescents diagnosed or hospitalized with coronavirus disease 2019 (COVID-19) to compare them in secondary analyses patients previous seasonal influenza 2017–2018. METHODS International network cohort using real-world data from European primary care records (France, Germany, Spain), South Korean claims US claims, hospital databases. We included and/or COVID-19 at...
Thrombosis with thrombocytopenia syndrome (TTS) has been reported among individuals vaccinated adenovirus-vectored COVID-19 vaccines. In this study, we describe the background incidence of non-vaccine induced TTS in six European countries.Electronic medical records from France, Netherlands, Italy, Germany, Spain, and United Kingdom informed study. Incidence rates cerebral venous sinus thrombosis (CVST), splanchnic vein (SVT), deep (DVT), pulmonary embolism (PE), myocardial infarction or...
Abstract Background We investigated whether we could use influenza data to develop prediction models for COVID-19 increase the speed at which can reliably be developed and validated early in a pandemic. Estimated Risk (COVER) scores that quantify patient’s risk of hospital admission with pneumonia (COVER-H), hospitalization requiring intensive services or death (COVER-I), fatality (COVER-F) 30-days following diagnosis using historical from patients flu-like symptoms tested this patients....
Purpose: The COVID-19 pandemic profoundly affected healthcare systems and patients. There is a need to comprehend the collateral effects of on non-communicable diseases. We examined impact short-term survival for common solid tumours, including breast, colorectal, head neck, liver, lung, oesophageal, pancreatic, prostate, stomach cancer in UK. Methods: This was population-based cohort study electronic health records from UK primary care Clinical Practice Research Datalink GOLD database. In...
Abstract Background In this study we phenotyped individuals hospitalised with coronavirus disease 2019 (COVID-19) in depth, summarising entire medical histories, including medications, as captured routinely collected data drawn from databases across three continents. We then compared COVID-19 to those previously influenza. Methods report demographics, recorded conditions and medication use of patients the US (Columbia University Irving Medical Center [CUIMC], Premier Healthcare Database...
ObjectiveThe aim of this study was to estimate lifetime risk knee and hip replacement following a GP diagnosis osteoarthritis assess how varies with patient characteristics.MethodsRoutinely collected data from Catalonia, Spain, covering 2006 2015, were used. Study participants had newly recorded or osteoarthritis. Parametric survival models specified for knee/hip death diagnosis. Survival combined using Markov model estimated the average profile. The effects age at diagnosis, sex,...
Concern has been raised in the rheumatology community regarding recent regulatory warnings that HCQ used coronavirus disease 2019 pandemic could cause acute psychiatric events. We aimed to study whether there is risk of incident depression, suicidal ideation or psychosis associated with as for RA.