Rupa Makadia
A5013899814- SARS-CoV-2 and COVID-19 Research
- Biomedical Text Mining and Ontologies
- COVID-19 Clinical Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Microscopic Colitis
- Peripheral Neuropathies and Disorders
- Inflammatory Bowel Disease
- Colorectal and Anal Carcinomas
- Machine Learning in Healthcare
- Health, Environment, Cognitive Aging
- Vaccine Coverage and Hesitancy
- Autoimmune and Inflammatory Disorders Research
- Drug-Induced Ocular Toxicity
- Healthcare cost, quality, practices
- Hidradenitis Suppurativa and Treatments
- Long-Term Effects of COVID-19
- Rheumatoid Arthritis Research and Therapies
- Anorectal Disease Treatments and Outcomes
- Blood groups and transfusion
- Pneumocystis jirovecii pneumonia detection and treatment
- Health Policy Implementation Science
- Chronic Disease Management Strategies
- Maternal Mental Health During Pregnancy and Postpartum
- Semantic Web and Ontologies
- Pharmacovigilance and Adverse Drug Reactions
Janssen (United States)
2015-2025
Istanbul University
2023
University of California, Los Angeles
2023
Abstract Objectives To evaluate the utility of applying Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) across multiple observational databases within an organization and to apply standardized analytics tools for conducting research. Materials methods Six deidentified patient-level datasets were transformed OMOP CDM. We evaluated extent information loss that occurred through standardization process. developed a analytic tool replicate cohort construction process...
Abstract Objective To quantify the background incidence rates of 15 prespecified adverse events special interest (AESIs) associated with covid-19 vaccines. Design Multinational network cohort study. Setting Electronic health records and claims data from eight countries: Australia, France, Germany, Japan, Netherlands, Spain, United Kingdom, States, mapped to a common model. Participants 126 661 070 people observed for at least 365 days before 1 January 2017, 2018, or 2019 13 databases. Main...
Hydroxychloroquine, a drug commonly used in the treatment of rheumatoid arthritis, has received much negative publicity for adverse events associated with its authorisation emergency use to treat patients COVID-19 pneumonia. We studied safety hydroxychloroquine, alone and combination azithromycin, determine risk routine care arthritis.
Abstract Objective Cohort definition is a bottleneck for conducting clinical research and depends on subjective decisions by domain experts. Data-driven cohort appealing but requires substantial knowledge of terminologies data models. Criteria2Query natural language interface that facilitates human-computer collaboration execution using databases. Materials Methods uses hybrid information extraction pipeline combining machine learning rule-based methods to systematically parse eligibility...
ABSTRACT Background Hydroxychloroquine has recently received Emergency Use Authorization by the FDA and is currently prescribed in combination with azithromycin for COVID-19 pneumonia. We studied safety of hydroxychloroquine, alone azithromycin. Methods New user cohort studies were conducted including 16 severe adverse events (SAEs). Rheumatoid arthritis patients aged 18+ initiating hydroxychloroquine compared to those sulfasalazine followed up over 30 days. Self-controlled case series...
Background: The Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) has been implemented on various claims and electronic health record (EHR) databases, but not applied to a hospital transactional database. This study addresses the implementation of OMOP CDM U.S. Premier Hospital database.Methods: We designed an extract, transform, load (ETL) process convert database into CDM. Standard charge codes in were mapped between version 4.0 Vocabulary standard descriptions....
Abstract Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use patients. Here, we describe characteristics adults COVID-19 compare them influenza We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) patients, summarising between 4811 11,643 unique aggregate characteristics. patients have been majority male in US Spain, predominantly female...
Major depressive disorder may be due to psychoneuroimmunological dysfunction, as studies have documented increased levels of a variety inflammatory mediators in depressed subjects. Nitric oxide (NO) is marker inflammation, and fractional exhaled NO (FeNO) airway inflammation. Plasma FeNO been shown lower subjects with depression small studies. We sought assess the association C-reactive protein (CRP) large representative sample US population.Population-based cross-sectional study using data...
Summary Background As large-scale immunization programs against COVID-19 proceed around the world, safety signals will emerge that need rapid evaluation. We report population-based, age- and sex- specific background incidence rates of potential adverse events special interest (AESI) in eight countries using thirteen databases. Methods This multi-national network cohort study included electronic medical record five administrative claims databases from Australia, France, Germany, Japan,...
Abstract Background In this study we phenotyped individuals hospitalised with coronavirus disease 2019 (COVID-19) in depth, summarising entire medical histories, including medications, as captured routinely collected data drawn from databases across three continents. We then compared COVID-19 to those previously influenza. Methods report demographics, recorded conditions and medication use of patients the US (Columbia University Irving Medical Center [CUIMC], Premier Healthcare Database...
Concern has been raised in the rheumatology community regarding recent regulatory warnings that HCQ used coronavirus disease 2019 pandemic could cause acute psychiatric events. We aimed to study whether there is risk of incident depression, suicidal ideation or psychosis associated with as for RA.
This paper introduces a novel framework for evaluating phenotype algorithms (PAs) using the open-source tool, Cohort Diagnostics. The method is based on several diagnostic criteria to evaluate patient cohort returned by PA. Diagnostics include estimates of incidence rate, index date entry code breakdown, and prevalence all observed clinical events prior to, on, after date. We test our one PA systemic lupus erythematosus (SLE) two PAs Alzheimer's disease (AD) across 10 different observational...
To complement and support routine pharmacovigilance, Janssen conducted rapid real-world data analyses for near real-time safety monitoring of the COVID-19 vaccine to contextualize potential signals. Analyses were performed in four U.S. healthcare claims databases (February 2022-May 2023) using standardized algorithms three exposures, 56 outcomes, 93 negative controls. Three self-controlled case series two comparative cohort variants conducted, each with consideration multiple at-risk periods...
Background Adverse events of special interest (AESIs) were pre-specified to be monitored for the COVID-19 vaccines.Some AESIs are not only associated with vaccines, but COVID-19.Our aim was characterise incidence rates following SARS-CoV-2 infection in patients and compare these historical general population.Methods A multi-national cohort study data from primary care, electronic health records, insurance claims mapped a common model.This study's evidence collected between Jan 1, 2017...
Objective: Background incidence rates are routinely used in safety studies to evaluate an association of exposure and outcome. Systematic research on sensitivity the choice study parameters is lacking. Materials Methods: We 12 data sources systematically examine influence age, race, sex, database, time-at-risk, season year, prior observation clean window using 15 adverse events special interest for COVID-19 vaccines as example. For binary comparisons we calculated rate ratios performed...
Vaccine-induced thrombotic thrombocytopenia (VITT) has been identified as a rare but serious adverse event associated with coronavirus disease 2019 (COVID-19) vaccines. In this study, we explored the pre-pandemic co-occurrence of thrombosis (TWT) using 17 observational health data sources across world. We applied multiple TWT definitions, estimated background rate TWT, characterized patients, and makeup types among patients. conducted an international network retrospective cohort study...
Hidradenitis suppurativa (HS) is a chronic, debilitating, inflammatory disease. Contemporaneous real-world data can be used to elucidate the clinical treatment of pediatric patients and how strategies compare with adult hidradenitis patients.
Background:The risk of stroke in atrial fibrillation (AF) increases with number factors (RFs). However, the combined effect from multiple RFs on incidence ischemic and transient attack (TIA) among US patients without AF has not been fully examined.Methods results:Truven MarketScan Medicare Supplemental database was used to establish cohorts ≥65 years old AF. Index date first occurrence diagnosis (AF patients) or medical encounter (non-AF during inception period 2010 through 2011. Incidences...
ABSTRACT Objective This paper introduces a novel framework for evaluating phenotype algorithms (PAs) using the open-source tool, Cohort Diagnostics. Materials and Methods The method is based on several diagnostic criteria to evaluate patient cohort returned by PA. Diagnostics include estimates of incidence rate, index date entry code breakdown, prevalence all observed clinical events prior to, on, after date. We test our one PA systemic lupus erythematosus (SLE) two PAs Alzheimer’s disease...
ABSTRACT Objective Most patients severely affected by COVID-19 have been elderly and with underlying chronic disease such as diabetes, cardiovascular disease, or respiratory disease. People living HIV (PLHIV) may greater risk of contracting developing severe due to the infection higher prevalence comorbidities. Design This is a cohort study, including PLHIV diagnosed, hospitalized, requiring intensive services for COVID-19. Methods Data sources include routine electronic medical record...
ABSTRACT Objectives Concern has been raised in the rheumatological community regarding recent regulatory warnings that hydroxychloroquine used COVID-19 pandemic could cause acute psychiatric events. We aimed to study whether there is risk of incident depression, suicidal ideation, or psychosis associated with as for rheumatoid arthritis (RA). Methods New user cohort using claims and electronic medical records from 10 sources 3 countries (Germany, UK US). RA patients aged 18+ initiating were...
ABSTRACT Background incidence rates are routinely used in safety studies to evaluate the association of an exposure and outcome. Systematic research on sensitivity background choice study parameters is lacking. We 12 electronic health record administrative claims data sources calculate 15 adverse events. examined influence age, race, sex, database, time-at-risk start (anchoring) event duration, season year, prior observation clean window. For binary comparisons, we calculated rate ratios...
Abstract Background There has been a more pronounced shift toward earlier, aggressive therapies in Crohn’s disease than ulcerative colitis (UC). The aim of this study was to describe the pre-biologic treatment and health care experience, including co-morbidities overall utilization, for UC patients who initiated biologic five years prior initiation first agent. Methods agent approved between 9/15/2005 1/30/2018 were identified from IBM ® MarketScan Commercial claims database. date recorded...
Abstract Background There has been a more pronounced shift toward earlier, aggressive therapies in Crohn’s disease than ulcerative colitis (UC). The aim of this study was to describe the pre-biologic treatment and health care experience, including co-morbidities overall utilization, for UC patients who initiated biologic therapies, 5 years prior initiation first agent. Methods agent approved between 9/15/2005 1/30/2018 were identified from IBM® MarketScan® Commercial Database, large US...