A5087667601- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Blood Coagulation and Thrombosis Mechanisms
- Pharmacovigilance and Adverse Drug Reactions
- Pharmacogenetics and Drug Metabolism
- Acute Myocardial Infarction Research
- ECG Monitoring and Analysis
- Pharmaceutical studies and practices
- Antibiotics Pharmacokinetics and Efficacy
- Drug Transport and Resistance Mechanisms
- Diabetes Treatment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Poisoning and overdose treatments
- Lipoproteins and Cardiovascular Health
- Heparin-Induced Thrombocytopenia and Thrombosis
- SARS-CoV-2 and COVID-19 Research
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Vaccine Coverage and Hesitancy
- Cardiac electrophysiology and arrhythmias
- Computational Drug Discovery Methods
- Analytical Methods in Pharmaceuticals
- Artificial Intelligence in Healthcare and Education
Johnson & Johnson (United States)
2010-2025
Janssen (Belgium)
2013-2021
Janssen (United States)
2014-2021
Johnson & Johnson (Sweden)
2021
Janssen Scientific Affairs (United States)
2015-2019
Scripps Research Institute
2017-2019
Tufts University
2014
Naval Medical Center Portsmouth
2014
Institut des Maladies Métaboliques et Cardiovasculaires
2012
AstraZeneca (United States)
2003-2007
Opportunistic screening for atrial fibrillation (AF) is recommended, and improved methods of early identification could allow the initiation appropriate therapies to prevent adverse health outcomes associated with AF.To determine effect a self-applied wearable electrocardiogram (ECG) patch in detecting AF clinical consequences such detection strategy.A direct-to-participant randomized trial prospective matched observational cohort study were conducted among members large national plan....
The 4'-hydroxylation of the S-enantiomer anticonvulsant drug mephenytoin exhibits a genetic polymorphism in humans. This shows marked interracial heterogeneity, with poor metabolizer (PM) phenotype representing 2 to 5% Caucasian and 13 23% Asian populations. Two defective CYP2C19 alleles, CYP2C19*2 CYP2C19*3, have been described which account for approximately 87% > 99% Oriental PM alleles. present study identifies new allele (CYP2C19*4) PMs contains an A-->G mutation initiation codon. A...
ABSTRACT Background In nonvalvular atrial fibrillation ( NVAF ), rivaroxaban is used to prevent stroke and systemic embolism. Objective To evaluate major bleeding (MB) in patients treated with a real‐world clinical setting. Methods From January 1, 2013, March 31, 2014, US Department of Defense electronic health care records were queried describe MB rates demographics. Major was identified using validated algorithm. Results Of 27 467 receiving rivaroxaban, 496 events occurred 478 patients, an...
The success of vaccination efforts to curb the COVID-19 pandemic will require broad public uptake immunization and highlights importance understanding factors associated with willingness receive a vaccine.U.S. adults aged 65 older enrolled in HeartlineTM clinical study were invited complete vaccine assessment through mobile application between November 6-20, 2020. Factors evaluated using an ordered logistic regression as well Random Forest classification algorithm.Among 9,106 participants,...
Aim: G‐protein coupled receptor agonists are currently under investigation for their potential utility in patients with type 2 diabetes mellitus (T2DM). The objective was to determine the pharmacokinetics, pharmacodynamics, safety and tolerability of GPR119 agonist, JNJ‐38431055 T2DM subjects. Methods: This a randomized, double‐blind, placebo‐ positive‐controled, single‐dose cross‐over study placebo‐controled multiple‐dose parallel design study. conducted at 4 US research centres. Two...
Ximelagatran, an oral direct thrombin inhibitor, whose active form is melagatran, was studied using a model of generation in humans. Healthy male volunteers (18 per group) received ximelagatran (60 mg p.o.), dalteparin (120 IU/kg s.c.) or control (water p.o.). Shed blood, collected after incision the forearm with standardised bleeding time devices at pre-dose, and 2, 4 10 h post-dosing, analysed for markers generation. Statistically significant reductions (p < 0.05) levels prothrombin...
Summary The objectives were to investigate whether activation of the extrinsic coagulation cascade by recombinant factor VIIa (rFVIIa) reverses inhibition thrombin generation and platelet melagatran, active form oral direct inhibitor ximelagatran. In a single-blind, randomized, parallel-group study, volunteers (20 per group) received 5-hour intravenous (iv) infusion achieve steadystate melagatran plasma concentrations approximately 0.5 µmol/L, with single iv bolus rFVIIa (90 µg/kg) or...
Efficient methods for screening populations undiagnosed atrial fibrillation (AF) are needed to reduce its associated mortality, morbidity, and costs. The use of digital technologies, including wearable sensors large health record data sets allowing targeted outreach toward individuals at increased risk AF, might allow unprecedented opportunities effective, economical screening. trial's primary objective is determine, in a real-world setting, whether using risk-targeted population can...
Isoniazid (INH), a widely used drug in the prophylaxis and treatment of tuberculosis, is associated with 1 to 2% risk severe potentially fatal hepatotoxicity. There evidence that INH metabolite hydrazine plays an important role mechanism this toxicity. Metabolism leads production via both direct indirect pathways. In cases, activity amidase required hydrolyze amide bond. present study, using model INH-induced hepatotoxicity rabbits, pretreatment rabbits inhibitor bis-p-nitrophenyl phosphate...
Because some patients have difficulty swallowing a whole tablet, we investigated the relative bioavailability of crushed 20 mg rivaroxaban tablet and 2 alternative dosing strategies.Stability nasogastric (NG) tube adsorption characteristics were assessed. Then, in 55 healthy adults, administered orally as (Reference [Whole-Oral]), applesauce suspension (Crushed-Oral), or water via NG (Crushed-NG) determined.There no significant changes mean percent non-degraded recovered over 4 hours from...
Objective This study evaluates the cost-effectiveness of vancomycin serum concentration monitoring in patients with hematologic malignancies. Methods The was designed as a prospective randomized study. Seventy immunocompromised febrile malignancies were randomly assigned to either therapeutic drug group (TDM group; n = 37) or control (n 33). Intervention TDM involved patient follow-up by clinical pharmacist obtain and pharmacokinetically interpret concentrations for dosage individualization....
The incidence of type 2 diabetes mellitus is increasing worldwide. Several G–protein–coupled receptor agonists are being studied for their efficacy as antidiabetes agents. JNJ–38431055 a novel, potent, and orally available selective agonist the glucose–dependent insulinotropic (GPR119) receptor. Double–blind, randomized, placebo–controlled studies were conducted to evaluate safety, tolerability, pharmacokinetics, pharmacodynamics single oral doses (2.5–800 mg) in healthy male volunteers....
Torcetrapib, a prototype cholesteryl ester transfer protein (CETP) inhibitor with potential for decreasing atherosclerotic disease, increased cardiovascular events in clinical trials. The identified hypertensive and aldosterone-elevating actions of torcetrapib may not fully account this elevated risk. Therefore, we evaluated the effects on endothelial mediated vasodilation vivo.In vivo was assessed using ultrasound imaging acetylcholine-induced changes rabbit central ear artery diameter....
The advent of large databases, wearable technology, and novel communications methods has the potential to expand pool candidate research participants offer them flexibility convenience participating in remote research. However, reports their effectiveness are sparse. We assessed use various forms outreach within a nationwide randomized clinical trial being conducted entirely by means.Candidate at possibly higher risk for atrial fibrillation were identified means insurance claims database...
A bstract BACKGROUND The success of vaccination efforts to curb the COVID-19 pandemic will require broad public uptake immunization and highlights importance understanding factors associated with willingness receive a vaccine. METHODS Adults enrolled in Heartline™ clinical study were invited complete vaccine assessment through mobile application between November 6-20, 2020. Factors evaluated using an ordered logistic regression as well Random Forest classification algorithm. RESULTS Among...
A pharmacokinetic interaction between erythromycin and ximelagatran, an oral direct thrombin inhibitor, was demonstrated in this study healthy volunteers. To investigate possible mechanisms, the effects of on active transport mediated by P-glycoprotein (P-gp) vitro Caco-2 P-gp-over-expressing Madin-Darby canine kidney-human multidrug resistance-1 cell preparations biliary excretion melagatran rats were studied. In volunteers (seven males nine females; mean age 24 years) receiving a single...
Background Atrial fibrillation (AF) is common, often without symptoms, and an independent risk factor for mortality, stroke heart failure. It unknown if screening asymptomatic individuals AF can improve clinical outcomes. Methods mSToPS was a pragmatic, direct-to-participant trial that randomized from single US-wide health plan to either immediate or delayed using continuous-recording ECG patch be worn two weeks 2 occasions, ~3 months apart, potentially detect undiagnosed AF. The 3-year...
Ximelagatran-a direct thrombin inhibitor rapidly converted to its active form, melagatran, after oral administration-is being developed for the prevention and treatment of thromboembolic disease. The pharmacokinetics, pharmacodynamics, tolerability/safety ximelagatran following a single 36-mg dose +/- alcohol (0.5 0.6 g ethanol/kg women men, respectively) were assessed in randomized, open-label, two-way crossover study (n = 26). 90% confidence intervals (CIs) least squares mean estimates...