A5101748204- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Health Systems, Economic Evaluations, Quality of Life
- Lipoproteins and Cardiovascular Health
- Heart Rate Variability and Autonomic Control
- Meta-analysis and systematic reviews
- Cardiac, Anesthesia and Surgical Outcomes
- Renin-Angiotensin System Studies
- Pharmaceutical Practices and Patient Outcomes
- Sodium Intake and Health
- Pharmacology and Obesity Treatment
- Health Sciences Research and Education
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pharmaceutical Economics and Policy
- Clinical practice guidelines implementation
- Drug-Induced Hepatotoxicity and Protection
- scientometrics and bibliometrics research
- Hemodynamic Monitoring and Therapy
- Cardiovascular Syncope and Autonomic Disorders
- Pharmacogenetics and Drug Metabolism
- Cancer, Lipids, and Metabolism
- Delphi Technique in Research
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Neuroscience and Neuropharmacology Research
University of British Columbia
2016-2025
Cochrane
2003-2025
Therapeutics Clinical Research
2022
University of Manchester
2022
Ottawa Hospital Research Institute
2022
University of Liverpool
2022
Ottawa Hospital
2022
MRC Clinical Trials Unit at UCL
2022
St Michael’s Hospital
2022
Unity Health Toronto
2022
<h3>Background:</h3> The annual cut-off date of birth for entry to school in British Columbia, Canada, is Dec. 31. Thus, children born December are typically the youngest their grade. We sought determine influence relative age within a grade on diagnosis and pharmacologic treatment attention-deficit/hyperactivity disorder (ADHD) children. <h3>Methods:</h3> conducted cohort study involving 937 943 Columbia who were 6–12 years at any time between 1, 1997, Nov. 30, 2008. calculated absolute...
A review of statins for primary prevention cardiovascular disease could alter guidance those with a 10 year risk less than 10%.<b> John Abramson and colleagues </b>argue that have no overall health benefit in this population prescribing guidelines should not be broadened
Bias in studies of preventive medications can occur when healthier patients are more likely to initiate and adhere therapy than less healthy patients. We sought evidence this bias by examining associations between statin exposure various outcomes that should not be causally affected exposure, such as workplace motor vehicle accidents.We conducted a prospective cohort study using data from British Columbia, Canada, multiethnic society with population 4.3 million people. Study subjects were...
The 4'-hydroxylation of the S-enantiomer anticonvulsant drug mephenytoin exhibits a genetic polymorphism in humans. This shows marked interracial heterogeneity, with poor metabolizer (PM) phenotype representing 2 to 5% Caucasian and 13 23% Asian populations. Two defective CYP2C19 alleles, CYP2C19*2 CYP2C19*3, have been described which account for approximately 87% > 99% Oriental PM alleles. present study identifies new allele (CYP2C19*4) PMs contains an A-->G mutation initiation codon. A...
Clinical trials and meta-analyses have found that rosiglitazone maleate, a thiazolidinedione is prescribed for type 2 diabetes mellitus, increases the risk of fractures in women. The association between use thiazolidinediones men women not adequately understood.We conducted prospective cohort study. primary outcome was peripheral who were exposed to compared with sulfonylureas. We studied 84 339 patients from British Columbia, Canada, began treatment or sulfonylurea. examined using...
Assessing the process used to synthesize evidence in clinical practice guidelines enables users determine trustworthiness of recommendations. Clinicians are increasingly dependent on keep up with vast quantities medical literature, and followed avoid malpractice suits. We aimed assess whether systematic methods were when synthesizing for guidelines; type review cited support
We studied the effect of isoniazid administration on cytochrome P4502E1—catalyzed elimination chlorzoxazone and acetaminophen. Isoniazid, 300 mg daily, was administered for 7 days to a group 10 volunteer slow acetylators. Acetaminophen, 500 mg, chlorzoxazone, 750 were separate occasions before isoniazid, during period administration, after discontinuation isoniazid. Isoniazid inhibited clearance by 58%, as assessed from plasma data, formation acetaminophen thioether metabolites (a measure...