A5089800626- Blood Pressure and Hypertension Studies
- Renin-Angiotensin System Studies
- Health Systems, Economic Evaluations, Quality of Life
- Hormonal Regulation and Hypertension
- Ethics in Clinical Research
- Heart Rate Variability and Autonomic Control
- Biomedical Ethics and Regulation
- Stress Responses and Cortisol
- COVID-19 and Mental Health
- Global Public Health Policies and Epidemiology
- Lipoproteins and Cardiovascular Health
- COVID-19 diagnosis using AI
- Turkish Literature and Culture
- Infective Endocarditis Diagnosis and Management
- COVID-19 and healthcare impacts
- Water Quality Monitoring Technologies
- Statistical Methods in Clinical Trials
- Anesthesia and Neurotoxicity Research
- Sodium Intake and Health
- Hypothalamic control of reproductive hormones
- Medication Adherence and Compliance
- Biomarkers in Disease Mechanisms
- Healthcare Systems and Reforms
- Gout, Hyperuricemia, Uric Acid
- Aluminum toxicity and tolerance in plants and animals
Istanbul University
2013-2024
Burdur Mehmet Akif Ersoy Üniversitesi
2024
Erasmus MC
2023
Janssen (United States)
2023
University of Hong Kong
2022
Istanbul Bilim University
2019
Selçuk University
2016
Ondokuz Mayıs University
1995
University Hospital of Lausanne
1984
Background Adverse events of special interest (AESIs) were pre-specified to be monitored for the COVID-19 vaccines.Some AESIs are not only associated with vaccines, but COVID-19.Our aim was characterise incidence rates following SARS-CoV-2 infection in patients and compare these historical general population.Methods A multi-national cohort study data from primary care, electronic health records, insurance claims mapped a common model.This study's evidence collected between Jan 1, 2017...
Aliskiren is the newest antihypertensive drug and first orally active direct renin inhibitor to become available for clinical use. Clinical data have substantiated that effectiveness of aliskiren similar other major agents. Furthermore, has a safety profile placebo. Combination treatment with showed significant blood pressure proteinuria reductions compared monotherapy. decreases plasma activity in contrast renin–angiotensin–aldosterone related drugs. The efficacy treating cardiovascular...
Objective Clinical research has faced new challenges during the COVID-19 pandemic, leading to excessive operational demands affecting all stakeholders. We evaluated impact of on clinical strategies and compared different adaptations by regulatory bodies academic institutions in a global context, exploring what can be learned for possible future pandemics. Methods conducted cross-sectional online survey identified assessed COVID-19-specific adaptation used bodies. Results All 19 participating...
Background Diabetes mellitus is an important risk factor for dementia, Alzheimer's disease, and other neurodegenerative diseases. Recent findings have made the relationship between inhibition of dipeptidyl peptidase-4 (DPP-4) enzyme cognitive functions research topic. Objective This study aimed to evaluate association DPP-4 inhibitor use functions, serum brain-derived neurotrophic (BDNF), pentraxin-3 (PTX-3) levels in patients with type 2 diabetes, compared who only metformin treatment....
Abstract Importance Drug shortages leave affected patients in a vulnerable position. Objective To describe incidence and prevalence of use for medicines with suggested at least one European country, as announced by the Medicines Agency, to characterise users these drugs including indication use, duration dosage. Design We performed descriptive cohort study from 2010 up 2024 network databases which have mapped their data Observational Medical Outcomes Partnership (OMOP) Common Data Model...
The aim of the present study was to evaluate efficacy and safety S-amlodipine 2.5 5 mg/d in patients with hypertension who were treatment-naive or previously received antihypertensive monotherapy. During 8-week treatment period, all for first 4 weeks, followed by second weeks. For assessments, ambulatory office blood pressure (BP) measurements performed during baseline, fourth-week, eighth-week visits. adverse events abnormal laboratory findings recorded. This is registered...
The progress of electronic health technologies and biobanks holds enormous promise for efficient research. Evidence shows that studies based on sharing secondary use data/samples have the potential to significantly advance medical knowledge. However, such resources international collaboration is hampered by lack clarity about ethical legal requirements transfer data samples across borders.Here, International Clinical Trial Center Network (ICN) reports governing sample exchange (DSE) four...
The effect of antihypertensive drugs, especially drugs modulating the renin-angiotensin-aldosterone-system (RAAS), on neurodegenerative diseases still needs to be investigated. This study aimed compare effects three different (telmisartan, perindopril, and nebivolol) neuroprotection acetylcholine (ACh) levels against lipopolysaccharide (LPS)-induced injury in a differentiated SH-SY5Y cell line. Cells were treated with retinoic acid for differentiation neuronal phenotype. LPS 20 (μg/mL) was...
Summary: The efficacy of timing surgery (short segment fixation using transpedicular screws), in burst fractures thoracolumbar spine was evaluated between May 1993 and October 1994. patients were divided into two groups according to time elapsed injury operation. Cases operated on within the first 24 h taken as early group (n=10) cases later than after considered late (n=8). treatment assessed by evaluation sagittal index (SI) restoration reduction canal compromise. preand postoperative...
Gynecomastia is defined as benign proliferation of male breast glandular tissue. To date, the pathophysiology adolescent gynecomastia (AG) remains unclear. Kisspeptin a polypeptide that plays an important role in regulation hypothalamic-pituitary-gonadal hormonal axis. In this study, we investigated whether there relationship between kisspeptin and AG.This study included 40 males 9 18 years age diagnosed with gynecomastia. The control group consisted 30 young healthy same range. participants...
Renin Angiotensin Aldosterone System (RAAS) plays an important role in the development of hypertension. On other hand, hypertension is a well-known and independent risk factor for cognitive impairment. The aim present study was to evaluate relationship blood pressure control, plasma angiotensin peptides aldosterone with functions. Forty-one patients who were under treatment same antihypertensive medications at least three months included study. Plasma II, 1-7, IV, concentrations analyzed...
Tricuspid regurgitation is a condition that affects 1.6 million patients in the United States and independently associated with morbidity mortality. The TriClip™ procedure repairs tricuspid valve without need for open-heart surgery. aim of this study to evaluate cost-effectiveness treatment advanced from Turkish reimbursement agency perspective.Within scope study, general literature was searched order reach data on regurgitation. utilization health care services used expert panel...
Introduction This study aimed to evaluate drug-drug interactions (DDIs) and their association with the quality of life in patients hypertension. Materials methods cross-sectional included 123 DDIs were evaluated using Medscape Drug Interaction Checker Database (Medscape, New York, NY). The EuroQol-5D (EQ-5D) Quality Life Scale was used for each patient. Results overall blood pressure control rate (systolic/diastolic levels, <140/90 mmHg) 43% (53/123). age uncontrolled hypertension higher...
Objectives: To investigate drug adherence and lifestyle behaviors affecting the blood pressure (BP) control among hypertensive patients that have uncontrolled controlled BP. Methods: Seventy-eight BP 98 matched on age, gender, time since hypertension diagnosis number of antihypertensive drugs used were investigated using a standardized questionnaire to evaluate behaviors, adherence, use complementary alternative medicine, health related quality life. Drug-drug interactions evaluated with an...
Aim: Stress is a multidisciplinary field of research. Renin-angiotensin system (RAS) components have been shown to be involved in stress. Exercise also can considered as stress factor. The aim this study was investigate the RAS and effect chronic exercise on response prospective design. Material Methods: Twenty healthy volunteers were recruited study. Trier psychosocial test used simulate Blood pressure, heart rate, plasma renin activity angiotensin II, salivary cortisol measured. Subjective...
Objective: Clinical trials are essential tools for improving scientific knowledge and public health. With this work, it is aimed to evaluate the clinical landscape in Turkey. Method: To of Turkey, all registered on or before date 20.06.2019 ClinicalTrials.gov database were used. The filtered by study type, phase, funder current status trials, location. In addition, number Turkey was compared with some countries which selected based population trials. Results: total 3880. majority these...