A5085733466- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Peripheral Artery Disease Management
- Gastric Cancer Management and Outcomes
- Chemical Synthesis and Analysis
- Drug Transport and Resistance Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Barrier Structure and Function Studies
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Head and Neck Cancer Studies
- Antibiotics Pharmacokinetics and Efficacy
- Magnetic confinement fusion research
- Metastasis and carcinoma case studies
- Ionosphere and magnetosphere dynamics
- Radio Frequency Integrated Circuit Design
- 3D IC and TSV technologies
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Esophageal and GI Pathology
- Aortic aneurysm repair treatments
- Solar and Space Plasma Dynamics
- Colorectal and Anal Carcinomas
- Asymmetric Synthesis and Catalysis
Sapporo Medical University
2015-2025
The University of Tokyo
1952-2025
National Cancer Center
2025
Tokyo Institute of Technology
2024
Kishokai Medical Corporation
2022-2024
Nagoya Heart Center
2014-2024
Kyoto University Hospital
1999-2024
Ome Municipal General Hospital
2024
Wakayama Medical University
2023-2024
Meenakshi Academy of Higher Education and Research
2024
We present a digoxin-clarithromycin interaction in two patients whom digoxin concentrations were unexpectedly increased. The ratio of renal clearance to creatinine one patient was lower during the concomitant administration clarithromycin (0.64 and 0.73) than that after cessation (1.30 ± 0.20; mean SD). Because P-glycoprotein could play an important role secretion digoxin, we hypothesized decreases excretion by inhibiting P-glycoprotein-mediated transport. Digoxin transport evaluated with...
Neuromyelitis optica (NMO) is characterized by severe optic neuritis and longitudinally extended transverse myelitis (LETM). The clinical laboratory features of NMO are different from multiple sclerosis (MS).1 An autoantibody to aquaporin-4 (AQP4) has been detected exclusively in the sera.1 Moreover, we demonstrated an extensive loss AQP4 glial fibrillary acidic protein immunoreactivities perivascular regions with complement immunoglobulin deposition that suggests astrocytic impairment....
Frequency-domain optical coherence tomography (FD-OCT) is a novel, high resolution intravascular imaging modality. Intravascular ultrasound (IVUS) widely used conventional modality for achieving optimal stent deployment. The aim of this study was to evaluate the impact FD-OCT guidance coronary implantation compared with IVUS guidance.A total 70 patients de novo artery lesions and either unstable or stable angina pectoris were enrolled in randomized (optical [OCT] group: n=35, n=35). In OCT...
The crystal structure of realgar, AsS, has been worked out by the Fourier-synthesis method, using Weissenberg photographs (Cu Ka 2. ~-1.54/~).The signs for F's were initially derived phaseinequality relations Harkcr & Kasper.The unit cell a ~ 9.27, b 13.50, c ----6.56 A, fl --106 ° 37'.The space group is P21/n.The contains sixteen AsS.The built up separate As4S 4 molecules cradle type held together van der Waals forces.The cleavage and relationships to orpiment, As2S3, are explained in terms...
Chronic skin ulcers such as diabetic and venous leg are increasing a costly problem in healthcare. We have developed novel artificial dermis, collagen/gelatin sponge (CGS), which is capable of sustained release basic fibroblast growth factor (bFGF) for more than 10 days. The objective this study was to investigate the safety efficacy CGS impregnated with bFGF treatment chronic ulcers. Patients that had not healed at least 4 weeks were treated 7 or 14 μg/cm(2) after debridement, wound bed...
The structure of epidote, HCa~(A1, Fe)ALSi3Ola, has been refined by two-and three-dimensional syntheses.The revised structure, in favour which an earlier proposal was withdrawn, now confirmed.The is the mixed silicate type containing both SiO 4 and SilO 7 groups bound together Al, Al(Fe), Ca O atoms OH groups.Epidote alumino-silicate, like cyanite etc., as A1 form octahedral chains occupy bulk its structure.
In recent years, mental health management of employees in companies has become increasingly important. As the number psychotherapists is not enough, it necessary for to be able keep their wellness on own. A self-guided healthcare course using VR devices been developed, and its stress reduction effect validated previously. This study proposes a new version smartphones chatbots enhance convenience use maintain user motivation daily repeated use. The effects maintenance were acknowledged.
The hinotori Surgical Robot System obtained pharmaceutical approval for use in colorectal cancer surgery October 2022 Japan, and its advantages, including operating arm with eight axes, adjustable base, flexible 3D viewer, are expected to be utilized colon surgery. A 68-year-old woman presented our hospital abdominal pain was diagnosed cStageIIa (cT3N0M0) ascending underwent right hemicolectomy using the appropriate port placement on arc around hepatic flexure, which available both ileocecal...
The hinotori™ Surgical Robot System was approved for use in colorectal cancer surgery Japan 2022. This robot has advantages, such as an operation arm with eight axes, adjustable base, and a flexible three-dimensional viewer, is expected to be utilized rectal surgery. Herein, we report the world's first using System.A 71-year-old woman presented our hospital bloody stools. A colonoscopy revealed type 2 advanced rectum, histological examination exposed well-differentiated adenocarcinoma....
ABSTRACT Studying the roles of Hox genes in normal and pathological development skin hair requires identification downstream target genetically defined animal models. We show that transgenic mice overexpressing Hoxc13 differentiating keratinocytes follicles develop alopecia, accompanied by a progressive condition resembles ichthyosis. Large-scale analysis differential gene expression postnatal these identified 16 previously unknown 13 known as presumptive targets. The majority targets are...
We demonstrated a gas sensor fabricated by growing single-walled carbon nanotube (SWNT) thin film directly on conventional substrate. NO 2 and Cl were detected down to the ppb level under room-temperature operation with fast response. Using an electrical breakdown technique, response sensitivity was improved order of magnitude. The relationship between concentration derived based Langmuir adsorption isotherm, predicting detection limit 8 for . SWNT thin-film exhibits merits over other types...
Epicardial fat volume (EFV) has been implicated in coronary artery disease. Relationship between EFV and plaque vulnerability not elucidated. The aim of this study was to investigate the association with by using optical coherence tomography (OCT).We enrolled 117 patients who underwent multislice computed (MSCT) OCT. quantified on MSCT. Patients were categorized according tertiles EFV: low tertile, < 104.1 cm(3); mid-tertile, cm(3)≤ ≤ 130.7 high > cm(3). A total 180 vessels 221 plaques...
Antimicrobial activity of a crude aflatoxin preparation and B 1 was studied. They were found inactive against common gram-positive gram-negative bacteria at concentration 100 μg/ml. Both samples did, however, exhibit antimicrobial activity, though narrow limited, various strains Streptomyces Nocardia . The antibiotic action confirmed by bioautogram after thin-layer chromatography. Among seven microorganisms, including aflatoxin-sensitive -resistant strains, N. asteroides IFM 8 to reduce , in...
The changes in intrinsic motivation during engaging activities are important to understand for encouraging ongoing participation, such as research and development within companies where individual commitment is crucial, user-generated content platforms that rely on voluntary user contributions. This study proposes an experimental method derive honest reports of a numerical form from subjects, by combining the free-choice paradigm Becker-DeGroot-Marschak (BDM) mechanism. allows acquisition...
The purpose of this study was to characterize the transport mechanisms involved in renal tubular secretion quinolones. contribution P-glycoprotein quinolones elucidated using a kidney epithelial cell line, LLC-PK1, and its transfectant derivative LLC-GA5-COL150, which expresses human on apical membrane. transcellular levofloxacin, quinolone antibacterial drug, from basolateral side increased LLC-GA5-COL150 compared with that LLC-PK1 monolayers. apparent Michaelis constant maximum velocity...