A5053191594- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Anorectal Disease Treatments and Outcomes
- Colorectal and Anal Carcinomas
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Stoma care and complications
- Pelvic floor disorders treatments
- Pancreatic function and diabetes
- Organ Transplantation Techniques and Outcomes
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Treatments and Studies
- Pelvic and Acetabular Injuries
- Anatomy and Medical Technology
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Liver physiology and pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Surgical Simulation and Training
- Colorectal Cancer Screening and Detection
- Metastasis and carcinoma case studies
- Biliary and Gastrointestinal Fistulas
- Neuroendocrine Tumor Research Advances
Sapporo Medical University
2016-2025
Shinko Hospital
2013-2024
Weatherford College
2023
The Japanese Society of Gastroenterological Surgery
2022
Kogakuin University
2022
Jichi Medical University
2018-2020
Hyogo Prefectural Cancer Center
2019
Aichi Medical University
2017
Sapporo Medical University Hospital
2014
Ministry of Education, Culture, Sports, Science and Technology
2014
To elucidate the mechanisms of late asthmatic response (LAR) observed in subjects, we have developed an animal model LAR using guinea pigs. Fifty pigs were immunized with a mixture Ascaris suum extract and aluminum hydroxide then challenged inhalation without anesthesia. Twenty 50 showed dual which occurred 3 to 6 h after immediate (IAR). Histologic studies by rapid freezing liquid nitrogen or bronchoalveolar lavage (BAL) performed 14 these 20 compared those 10 18 only IAR, control pigs,...
The intrahepatic bile duct (IHBD) is a highly organized tubular structure consisting of cholangiocytes, biliary epithelial cells, which drains produced by hepatocytes into the duodenum. Although several models have been proposed, it remains unclear how three‐dimensional (3D) IHBD network develops during liver organogenesis. Using 3D imaging techniques, we demonstrate that continuous luminal IHBDs established 1 week after birth. Beyond this stage, consists large ducts running along portal...
The hinotori Surgical Robot System obtained pharmaceutical approval for use in colorectal cancer surgery October 2022 Japan, and its advantages, including operating arm with eight axes, adjustable base, flexible 3D viewer, are expected to be utilized colon surgery. A 68-year-old woman presented our hospital abdominal pain was diagnosed cStageIIa (cT3N0M0) ascending underwent right hemicolectomy using the appropriate port placement on arc around hepatic flexure, which available both ileocecal...
The hinotori™ Surgical Robot System was approved for use in colorectal cancer surgery Japan 2022. This robot has advantages, such as an operation arm with eight axes, adjustable base, and a flexible three-dimensional viewer, is expected to be utilized rectal surgery. Herein, we report the world's first using System.A 71-year-old woman presented our hospital bloody stools. A colonoscopy revealed type 2 advanced rectum, histological examination exposed well-differentiated adenocarcinoma....
To compare the prognoses of hepatocellular carcinoma (HCC) patients that underwent anatomic liver resection (AR) or non-anatomic (NAR) using propensity score-matched populations.Between January 2002 and December 2010, 268 consecutive HCC patients, including 110 158 AR NAR, respectively, were retrospectively enrolled in this study. Forty-four from each group selected matched logistic multivariate analysis followed by score analysis.In whole set, histological background liver, function, tumor...
Although MRI has a substantial role in directing treatment decisions for locally advanced rectal cancer, precise interpretation of the findings is not necessarily available at every institution. In this study, we aimed to develop artificial intelligence-based software segmentation cancer that can be used staging optimize strategy and preoperative surgical simulation.Images from total 201 patients who underwent were analyzed training data. The resected specimen was processed circular shape...
Aim In computed tomography colonography angiography (CTC-A), used for preoperative screening of right-sided colon cancer, the timing venous phase imaging is conventionally determined by a fixed-delay time; however, contrast effect may be insufficient because individual differences in blood flow status. Therefore, we developed double-bolus tracking (DBT) method to solve this issue. Method We compared and image quality portal systems between two methods conventional DBT which utilizes low-dose...
Abstract Background Accurate identification of tumor sites during laparoscopic colorectal surgery helps to optimize oncological clearance. We aimed assess the timing local injection preoperatively and clarify usefulness limitation site marking using indocyanine green (ICG) fluorescence imaging. Methods Consecutive patients who underwent primary cancer from September 2017 January 2019 were included. Preoperatively, lower endoscopy was used inject ICG solution into submucosal layer near tumor....
It has been proposed that tissue stem cells supply multiple epithelial in mature tissues and organs. However, it is unclear whether generally contribute to cellular turnover normal healthy Here, we show liver progenitors distinct from bipotent stem/progenitor (LPCs) persistently exist mouse livers potentially maintenance. We found that, addition LPCs isolated as EpCAM+ cells, were enriched CD45- TER119- CD31- EpCAM- ICAM-1+ fraction late-fetal postnatal livers. abundant by 4 weeks (4W) after...
An artificial intelligence-based algorithm we developed, mrAI, satisfactorily segmented the rectal tumor, rectum, and mesorectum from MRI data of cancer patients in an initial study. Herein, aimed to validate mrAI using independent dataset.
The low anterior resection syndrome (LARS) score is a patient-reported outcome measure to evaluate the severity of bowel dysfunction after rectal cancer surgery by scoring major symptoms LARS. aim this study was translate English version LARS into Japanese and investigate validity reliability score.The translated in following current international recommendations. A total 149 patients completed questionnaire were also asked single question assessing impact function on quality life (QoL). 136...
Abstract Semi‐serial sections from the lumbosacral region of nine fetuses (8–25 weeks gestation) were examined to clarify lumbar prevertebral fascial arrangement. The fasciae became evident after 12 age. After 20 age, hypogastric nerve (HGN) was sandwiched by two structures; ventral fascia which seemed correspond mesorectal fascia, whereas dorsal corresponded presacral fascia. These or HGN sheaths extended laterally along aspects great vessels and associated lymph follicles. is, some extent,...
Situs inversus totalis (SIT) denotes complete right-left inversion of the thoracic and abdominal viscera. Diagnosis surgical procedures for pathology in patients with SIT are technically more complicated because mirror-image transposition visceral organs. Moreover, is commonly associated cardiovascular hepatobiliary malformations, which make hepatobiliary-pancreatic surgery difficult. Two cases pancreaticoduodenectomy biliary tract carcinoma presented. Both had an anomaly hepatic artery....
In May 2023, the Hugo RAS system obtained pharmaceutical approval for use in gastroenterological surgery Japan. It is expected to be particularly effective rectal cancer surgery, which require manipulation of deep pelvic cavity and communication with surgeons operating from intraperitoneal anal approaches. A 68-year-old woman presented our hospital bloody stools was diagnosed cStage I (cT2N0M0) underwent abdominoperineal resection employing system. Two arm carts were placed on left right...
Small hepatocyte-like progenitor cells (SHPCs) transiently form clusters in rat livers treated with retrorsine (Ret)/70% partial hepatectomy (PH). When Thy1+ isolated from d-galactosamine-treated were transplanted into the of Ret/PH-treated rats, mass recipient liver increased during first 30 days after transplantation, suggesting that regeneration was enhanced. Here we addressed how cell transplantation stimulates regeneration. We found number and size SHPC at 14 transplantation. GeneChip...
Background The Pringle maneuver is used to minimize blood loss during liver transection; however, it may cause reperfusion injury, which can increased intraoperative lactate levels and an immune compromised state. This further lead infectious complications. Methods Here, we divided 77 patients who underwent hepatectomy between December 2007 August 2010 into two groups: the chronic hepatitis cirrhosis (CH + LC) group normal (NL) group. We investigated effect of highest level on occurrence...
Abstract Background Small hepatocyte-like progenitor cells (SHPCs) appear to form transient clusters in rat livers treated with retrorsine (Ret) and 70% partial hepatectomy (PH). We previously reported that the expansion of SHPCs was amplified Ret/PH-treated transplanted Thy1 + derived from d -galactosamine-treated injured livers. Extracellular vesicles (EVs) produced by hepatic donor activated via interleukin (IL)-17 receptor B signaling. As bone marrow-derived mesenchymal (BM-MCs) also...