A5006889095- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Nausea and vomiting management
- Anesthesia and Pain Management
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Neurological disorders and treatments
- Pathogenesis and Treatment of Hiccups
- Parkinson's Disease Mechanisms and Treatments
- Colorectal and Anal Carcinomas
- Organ Transplantation Techniques and Outcomes
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Anorectal Disease Treatments and Outcomes
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Clinical practice guidelines implementation
- Cancer Research and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Pelvic floor disorders treatments
Nagoya City University
2016-2025
Sapporo Medical University
2015-2024
Otaru Municipal Hospital
2024
Osaka Ekisaikai Hospital
2024
Wakayama Medical University
2024
Hyogo Prefectural Cancer Center
2024
Shikoku Cancer Center
2024
University of Tokyo Hospital
2024
Gifu University
2024
The Japanese Society of Gastroenterological Surgery
2022
Human gut microbiota is being increasingly recognized as a player in colorectal cancers (CRCs). Evidence suggests that Fusobacterium nucleatum (F. nucleatum) may contribute to disease progression and associated with CpG island methylator phenotype (CIMP) microsatellite instability (MSI) CRCs; however, date, there are no reports about the relationship between F. molecular features early stage of tumorigenesis. Therefore, we investigated presence premalignant lesions. In total, 465 lesions...
The interim analysis of the CIRCULATE-Japan GALAXY observational study demonstrated association circulating tumor DNA (ctDNA)-based molecular residual disease (MRD) detection with recurrence risk and benefit from adjuvant chemotherapy (ACT) in resectable colorectal cancer (CRC). This updated a 23-month median follow-up, including 2,240 patients stage II-III colon or IV CRC, reinforces prognostic value ctDNA positivity during MRD window significantly inferior disease-free survival (DFS;...
Abstract Patients with cancer should appropriately receive antiemetic therapies against chemotherapy-induced nausea and vomiting (CINV). Antiemetic guidelines play an important role in managing CINV. Accordingly, the first Japanese guideline published 2010 by Japan Society of Clinical Oncology (JSCO) has considerably aided medical staff providing across chemotherapy clinics. With yearly advancements therapies, require revisions according to evidence regarding management worldwide. A revised...
Abstract Aquaporin 4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorder (AQP4-IgG+NMOSD) is an autoimmune astrocytopathic disease pathologically characterized by the massive destruction and regeneration of astrocytes with diverse types tissue injury or without complement deposition. However, it unknown whether this diversity derived from differences in pathological processes temporal changes. Furthermore, unlike for demyelinating lesions multiple sclerosis, there has been no staging...
Abstract Background The Japan Society of Clinical Oncology Practice Guidelines for Antiemesis 2023 was extensively revised to reflect the latest advances in antineoplastic agents, antiemetics, and regimens. This update provides new evidence on efficacy antiemetic Methods Guided by Minds Guideline Development Manual 2017, a rigorous approach used guidelines; thorough literature search conducted from January 1, 1990, December 31, 2020. Results Comprehensive process resulted creation 13...
Abstract The purpose of this article is to disseminate the standard antiemetic therapy for Japanese clinical oncologists. On basis Appraisal Guidelines Research and Evaluation II instrument, which reflects evidence-based practice guidelines, a working group Society Clinical Oncology (JSCO) reviewed guidelines antiemesis performed systematic review domestic in Japan. In addition, because health-insurance systems Japan are different from those other countries, consensus was reached regarding...
The hinotori Surgical Robot System obtained pharmaceutical approval for use in colorectal cancer surgery October 2022 Japan, and its advantages, including operating arm with eight axes, adjustable base, flexible 3D viewer, are expected to be utilized colon surgery. A 68-year-old woman presented our hospital abdominal pain was diagnosed cStageIIa (cT3N0M0) ascending underwent right hemicolectomy using the appropriate port placement on arc around hepatic flexure, which available both ileocecal...
Subthalamic nucleus deep brain stimulation (STN-DBS) is effective for medically refractory Parkinson's disease. We retrospectively analyzed complications in 180 consecutive patients who underwent bilateral STN-DBS. Surgery-related were symptomatic intracerebral hemorrhage 2, chronic subdural hematoma 1, and transient deterioration of medication-induced psychosis 2 patients. Device-related involved device infection 5, skin erosion implantable pulse generator malfunction All these required...
// Tadashi Ogawa 1, 2 , Yoshihiko Hirohashi 1 Aiko Murai Toshihiko Nishidate Kenji Okita Liming Wang Yuzuru Ikehara 3 Tetsuta Satoyoshi Akihiro Usui Terufumi Kubo Munehide Nakastugawa Takayuki Kanaseki Tomohide Tsukahara Goro Kutomi Tomohisa Furuhata Koichi Hirata Noriyuki Sato Toru Mizuguchi Ichiro Takemasa and Torigoe Department of Pathology, Sapporo Medical University School Medicine, Chuo-Ku, 060-8556, Japan Surgery, The Molecular Medicine Team, Research Center for Glycoscience, National...
Although MRI has a substantial role in directing treatment decisions for locally advanced rectal cancer, precise interpretation of the findings is not necessarily available at every institution. In this study, we aimed to develop artificial intelligence-based software segmentation cancer that can be used staging optimize strategy and preoperative surgical simulation.Images from total 201 patients who underwent were analyzed training data. The resected specimen was processed circular shape...
The purpose of this study is to compare the efficacy a single administration dexamethasone (DEX) on day 1 against DEX days 1-3 in combination with palonosetron (PALO), second-generation 5-HT3 receptor antagonist, for chemotherapy-induced nausea and vomiting (CINV) non-anthracycline cyclophosphamide (AC) moderately-emetogenic chemotherapy (MEC). This phase III trial was conducted multi-center, randomized, open-label, non-inferiority design. Patients who received non-AC MEC as an initial were...
Abstract Background Accurate identification of tumor sites during laparoscopic colorectal surgery helps to optimize oncological clearance. We aimed assess the timing local injection preoperatively and clarify usefulness limitation site marking using indocyanine green (ICG) fluorescence imaging. Methods Consecutive patients who underwent primary cancer from September 2017 January 2019 were included. Preoperatively, lower endoscopy was used inject ICG solution into submucosal layer near tumor....
Tumor angiogenesis is an important therapeutic target in colorectal cancer (CRC). We aimed to identify novel genes associated with CRC. Using RNA sequencing analysis normal and tumor endothelial cells (TECs) isolated from primary CRC tissues, we detected frequent upregulation of adipocyte enhancer-binding protein 1 (AEBP1) TECs. Immunohistochemical revealed that AEBP1 upregulated TECs stromal tissues. Quantitative RT-PCR showed there little or no expression cell lines, but well expressed...
The low anterior resection syndrome (LARS) score is a patient-reported outcome measure to evaluate the severity of bowel dysfunction after rectal cancer surgery by scoring major symptoms LARS. aim this study was translate English version LARS into Japanese and investigate validity reliability score.The translated in following current international recommendations. A total 149 patients completed questionnaire were also asked single question assessing impact function on quality life (QoL). 136...
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is caused by mutations in CSF1R. Pathogenic exons 12-22 including coding sequence of the tyrosine kinase domain (TKD) CSF1R were previously identified. We aimed to identify patients who clinically suspected having ALSP determine pathogenicity novel variants.Sixty-one fulfilled diagnostic criteria included this study. Genetic analysis was performed for all exons. The haploinsufficiency examined frameshift RT-PCR....
Subthalamic nucleus deep brain stimulation (STN DBS) improves cardinal motor symptoms of Parkinson disease (PD) and reduces antiparkinsonian medication. Therefore, STN DBS seems to be well indicated for patients suffering from medication-induced psychotic symptoms. However, there are few available data dealing with the effect in this kind patient. The authors studied PD severe hallucinations or delusions.The retrospectively reviewed clinical course 10 who suffered delusions underwent...