A5022567080- Anesthesia and Pain Management
- Nausea and vomiting management
- Multiple and Secondary Primary Cancers
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Pathogenesis and Treatment of Hiccups
- Sperm and Testicular Function
- Sexual Differentiation and Disorders
- Lung Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- Iterative Learning Control Systems
- Urological Disorders and Treatments
- Gastric Cancer Management and Outcomes
- Systemic Lupus Erythematosus Research
- Testicular diseases and treatments
- Cancer-related Molecular Pathways
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- Frailty in Older Adults
- Adhesion, Friction, and Surface Interactions
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Urologic and reproductive health conditions
St. Luke's International University
2022-2025
Graduate School USA
2023
Saint Luke's College of Health Sciences
2023
Meikai University
2021
National Cancer Centre Japan
2017-2020
Saitama Medical University
2010-2018
Social Insurance Saitama Chuo Hospital
2010-2018
Tohoku University
2009-2016
National Cancer Center
2016
Osaka University
1963-2014
Abstract Patients with cancer should appropriately receive antiemetic therapies against chemotherapy-induced nausea and vomiting (CINV). Antiemetic guidelines play an important role in managing CINV. Accordingly, the first Japanese guideline published 2010 by Japan Society of Clinical Oncology (JSCO) has considerably aided medical staff providing across chemotherapy clinics. With yearly advancements therapies, require revisions according to evidence regarding management worldwide. A revised...
Abstract Background The Japan Society of Clinical Oncology Practice Guidelines for Antiemesis 2023 was extensively revised to reflect the latest advances in antineoplastic agents, antiemetics, and regimens. This update provides new evidence on efficacy antiemetic Methods Guided by Minds Guideline Development Manual 2017, a rigorous approach used guidelines; thorough literature search conducted from January 1, 1990, December 31, 2020. Results Comprehensive process resulted creation 13...
Objective Our study assessed the correlation between discrepancies in clinical and pathological T stages overall survival (OS) patients with upper urinary tract urothelial carcinoma (UTUC), including renal pelvis (UCP) ureter (UCU) carcinoma, treated radical surgery. Methods We utilized data from Japanese Hospital‐Based Cancer Registry (HBCR) to identify UTUC cases ( n = 2376), consisting of UCP 1196) UCU 1180), diagnosed cTa‐3N0M0 2012 2013. All were histologically confirmed solely surgery,...
The dystroglycan complex is a membrane-spanning composed of two subunits, α- and β-dystroglycan. α-dystroglycan cell surface peripheral membrane protein which binds to the extracellular matrix (ECM), whereas β-dystroglycan an integral anchors membrane. provides tight link between ECM Dysfunction has commonly been implicated in molecular pathogenesis severe forms hereditary neuromuscular diseases, including Duchenne muscular dystrophy, Fukuyama-type congenital dystrophy sarcoglycanopathy...
Dexamethasone, a synthetic glucocorticoid, has clinical benefit in patients with hormone-refractory prostate cancer (HRPC), but the mechanisms responsible for its effects are unknown. The nuclear factor-kappaB (NF-kappaB)-dependent cytokine interleukin (IL) 6 (IL-6) is thought to stimulate growth of HRPC. Because dexamethasone interferes NF-kappaB activation, we determined whether inhibits by working through glucocorticoid receptor (GR) interfere NF-kappaB-IL-6 pathway.Three human cell lines...
There is significant concern that cancer care adversely impacted due to the coronavirus disease pandemic. Using national database, we document impact of pandemic on diagnosis in Japan.Data from 735 hospital-based registries, covering >70% newly diagnosed cases, were analysed. We compared trends during 2016-2019 and those 2020 by type cancer, diagnostic process, stage 13 prefectures as requiring special precautions prevent spread infection.Overall, number patients who began treatment...
Background/Aim: This study aimed to elucidate the role of glutathione peroxidase 4 (GPX4) on sterol regulatory element binding proteins (SREBPs)-proliferation pathway in oral cancer cells, and determine its protein expression tissues. Materials Methods: Quantitative RT-PCR immunoblot analysis were carried out. Cell viability assay, apoptosis detection immunohistochemistry GPX4 knockdown performed. Results: The levels both mRNA highest SAS cells. a human squamous cell carcinoma line, using...
To clarify the long-term prognoses of elderly upper tract urothelial carcinoma (UTUC) patients after surgery. We used a hospital-based cancer registry data in Japan to extract with pT1-3N0M0 UTUC diagnosed 2009 who underwent surgery, and classified them by age group (≤ 64, 65–74, ≥ 75 years old). estimated 10-year overall survival (OS) Kaplan-Meier analysis. For estimation, we calculated net (NS) Pohar-Preme method using Japanese life tables. A total 1139 (564 renal pelvic [RPC] 575 ureteral...
To evaluate relationships between lesions in the lung periphery and surrounding structures, particularly vessels bronchi, axial multiplanar reconstruction (AMPR) computed tomography (CT) was used to study 26 patients who underwent surgical resection of pulmonary nodules less than 3 cm diameter. Findings at AMPR CT, conventional digital radiographic were compared with findings obtained evaluation resected specimen regard ability display vessels, lesions. CT significantly superior detecting...
To identify the prognosis of Japanese patients with collecting duct carcinoma (CDC). We used a hospital-based cancer registry data in Japan to extract CDC cases that were diagnosed 2013, histologically confirmed, and determined first course treatment. further investigated treatment modalities estimated overall survival (OS) by Kaplan–Meier method. A total 61 identified. The 5-year OS rate for all who during 2013 was 23.6% (95% CI: 15.0–37.4), median 14 months 12–24). at stages I, III, IV...
For preoperative evaluation of chest wall and mediastinal invasion by lung cancer, computed tomography (CT), combined with artificial pneumothorax (pneumothorax CT), was performed in 43 patients cancer whom conventional CT scans showed that the mass contiguous to (n = 30) and/or mediastinum 25) but without evidence definite tumor invasion. Invasion diagnosed on basis whether an air space existed between adjacent structures. In three not produced. After procedure, four developed symptomatic...
Because of the physiological decline and diversity preferences, treating older patients with cancer is challenging. Given insufficient evidence applicable to in patients, some clinical guidance necessary. This study provides a description current treatment practices Japan, which may shed light on possible options. Using data from national database hospital-based registries, we described first-course nine common cancers who received care Designated Cancer Care Hospitals between 2012 2015. We...
Abstract Background Hospital-based cancer registries were developed to describe and improve clinical care for patients. We described the hospital-based registry coverage as a reference users, including researchers, policymakers clinicians. Methods The was defined proportion of new cases registered in National Cancer Registry denominator. To examine respective types, age groups prefecture registry, grouped based on 10th International Statistical Classification Diseases Related Health Problems...
Background Pulsed cyclophosphamide or mycophenolate mofetil for lupus nephritis has limited efficacy. We previously reported a case of mixed-class IV + V successfully treated with and tacrolimus. This study assessed the efficacy safety multitarget therapy tacrolimus treatment nephritis. Methods In prospective, single-arm, open label pilot study, we recruited 15 patients aged 18–64 years active who met American College Rheumatology criteria diagnosis systemic erythematosus (1997). The...
Abstract Background Genitourinary sarcomas are rare in adults and few large-scale studies on adult genitourinary sarcoma reported. We aimed to elucidate the clinical characteristics, survival outcomes, prognostic factors for overall of Japan. Methods A hospital-based cancer registry data Japan was used identify enroll patients diagnosed with 2013. The datasets were registered from 121 institutions. Results total 116 men 39 women included, a median age 66 years. most common primary site...