A5060359948- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Testicular diseases and treatments
- Sarcoma Diagnosis and Treatment
- Urologic and reproductive health conditions
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Circadian rhythm and melatonin
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Sexual Differentiation and Disorders
- Radiopharmaceutical Chemistry and Applications
- Vascular Tumors and Angiosarcomas
- Ovarian cancer diagnosis and treatment
- Immune cells in cancer
- Prostate Cancer Diagnosis and Treatment
- Birth, Development, and Health
- Bone health and treatments
- Cardiac tumors and thrombi
- Multiple and Secondary Primary Cancers
- Lipid metabolism and biosynthesis
- Gastric Cancer Management and Outcomes
University of Tsukuba
2013-2025
University of Tsukuba Hospital
2020-2024
Tsukuba Medical Center Hospital
2022
Kyoto University
2022
Tokyo National Hospital
2018
Hitachi General Hospital
2016
Kameda Medical Center
2015
Objective Our study assessed the correlation between discrepancies in clinical and pathological T stages overall survival (OS) patients with upper urinary tract urothelial carcinoma (UTUC), including renal pelvis (UCP) ureter (UCU) carcinoma, treated radical surgery. Methods We utilized data from Japanese Hospital‐Based Cancer Registry (HBCR) to identify UTUC cases ( n = 2376), consisting of UCP 1196) UCU 1180), diagnosed cTa‐3N0M0 2012 2013. All were histologically confirmed solely surgery,...
Background/Objectives: Modern societal stressors have been linked to declining testosterone levels among young men, contributing somatic, psychological, and sexual health problems. Despite growing evidence suggesting a link between trace elements testosterone-related symptoms, there are only few comprehensive analyses on younger populations. This study's aim was examine how serum modulate the relationship symptom severity. Methods: cross-sectional study included 225 men seeking infertility...
Abstract Metastatic burden is a critical factor for therapy decision‐making in metastatic hormone‐sensitive prostate cancer. The present study aimed to identify prognostic factors men with high‐ or low‐metastatic treated primary androgen‐deprivation therapy. included 2450 de novo cancer who were at 30 institutions across Japan between 2008 and 2017. We investigated the value of various clinicopathological parameters progression‐free survival (PFS) overall (OS) patients stratified by low‐...
Renal cell carcinoma (RCC) features altered lipid metabolism and accumulated polyunsaturated fatty acids (PUFAs). Elongation of very long-chain acid (ELOVL) family enzymes catalyze elongation, ELOVL5 is indispensable for PUFAs but its role in RCC progression remains unclear. Here, we show that higher levels correlate with poor clinical prognosis. Liquid chromatography/electrospray ionization-tandem mass spectrometry analysis showed decreases end products (arachidonic eicosapentaenoic acid)...
Renal cell carcinoma (RCC) is an aggressive genitourinary malignancy which has been associated with a poor prognosis, particularly in patients metastasis, its major subtypes being clear RCC (ccRCC), papillary PCC (pRCC) and chromophobe (chRCC). The presence of intracellular lipid droplets (LDs) considered to be hallmark ccRCC. importance altered metabolism ccRCC widely recognized. elongation very‑long‑chain fatty acid (ELOVL) catalyzes the acids (FAs), modulating composition, required for...
PURPOSETo evaluate the safety and pathological complete response (pCR) rate of radiotherapy with atezolizumab as bladder-preserving therapy for invasive bladder cancer.PATIENTS AND METHODSA multicenter, phase II study was conducted clinically T2-3 or very high-risk T1 cancer patients who were poor candidates refused radical cystectomy. Here, we report our interim analysis pCR a key secondary endpoint ahead progression-free survival primary endpoint. Radiotherapy (41.4 Gy to small pelvic...
Abstract Purpose To investigate whether seminal plasma (SP)/serum ratios of multiple trace elements (TEs) can classify patients with male subfertility. Methods SP/serum 20 TEs (lithium, sodium, magnesium, phosphorus, sulfur, potassium, calcium, manganese, iron, cobalt, copper, zinc, arsenic, selenium, rubidium, strontium, molybdenum, cesium, barium, and thallium) were calculated for healthy volunteers ( n = 4) those consulting subfertility 245). Volunteer semen samples collected by split...
To identify the prognosis of Japanese patients with collecting duct carcinoma (CDC). We used a hospital-based cancer registry data in Japan to extract CDC cases that were diagnosed 2013, histologically confirmed, and determined first course treatment. further investigated treatment modalities estimated overall survival (OS) by Kaplan–Meier method. A total 61 identified. The 5-year OS rate for all who during 2013 was 23.6% (95% CI: 15.0–37.4), median 14 months 12–24). at stages I, III, IV...
To clarify the long-term prognoses of elderly upper tract urothelial carcinoma (UTUC) patients after surgery. We used a hospital-based cancer registry data in Japan to extract with pT1-3N0M0 UTUC diagnosed 2009 who underwent surgery, and classified them by age group (≤ 64, 65–74, ≥ 75 years old). estimated 10-year overall survival (OS) Kaplan-Meier analysis. For estimation, we calculated net (NS) Pohar-Preme method using Japanese life tables. A total 1139 (564 renal pelvic [RPC] 575 ureteral...
<title>Abstract</title> Squalene, a natural triterpene with antioxidant, anti-inflammatory, and immunostimulatory properties, holds promise for cancer therapy. Here, we examined previously developed, diethylene glycol derivative of squalene (SQ-diEG) investigated its in vivo anti-carcinogenic effects bladder cancer. C57BL/6 mice were treated 0.025% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) to induce cancer, SQ-diEG or PBS (control) administered orally from Week 0. significantly reduced...
Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal that involves various organs, but has predilection for the urinary bladder in genitourinary tract. Given approximately half of all IMT cases have anaplastic lymphoma kinase (ALK) rearrangements, ALK inhibitor crizotinib suggested as promising treatment unresectable cases. No reports on neoadjuvant therapy locally advanced are available. We report case 17-year-old Japanese boy referred to our institution painful urination and...
Oncogenic FGFR3-TACC3 fusions and FGFR3 mutations are target candidates for small molecule inhibitors in bladder cancer (BC). Because TACC3 genes located very closely on chromosome 4p16.3, detection of the fusion by DNA-FISH (fluorescent situ hybridization) is not a feasible option. In this study, we developed novel RNA-FISH assay using branched DNA probe to detect formaldehyde-fixed paraffin-embedded (FFPE) human BC samples.The was validated mouse xenograft model with cell lines. Next,...
Abstract Background Genitourinary sarcomas are rare in adults and few large-scale studies on adult genitourinary sarcoma reported. We aimed to elucidate the clinical characteristics, survival outcomes, prognostic factors for overall of Japan. Methods A hospital-based cancer registry data Japan was used identify enroll patients diagnosed with 2013. The datasets were registered from 121 institutions. Results total 116 men 39 women included, a median age 66 years. most common primary site...
ABSTRACT Background Inductively coupled plasma mass spectrometry (ICP‐MS) is widely used for the accurate measurement of minerals. However, its application to serum essential mineral has not been fully evaluated. The present study aimed assess performance ICP‐MS minerals by comparing measurements those obtained using standard quantification methods. Methods Cross‐sectional data were collected from 282 participants a single facility in Japan. Serum concentrations eight key minerals, namely...
Abstract The metastatic burden is a critical factor for decision‐making in the treatment of hormone‐sensitive prostate cancer (HSPC). This study aimed to develop and validate novel risk model survival patients with de novo low‐ high‐burden HSPC. retrospective observational included men who were treated primary androgen‐deprivation therapy at 30 institutions across Japan between 2008 2017. We created overall (OS) discovery cohort (n = 1449) stratified by (low vs high) validated its predictive...
Germ cell tumors are highly susceptible to chemotherapy; however, there is a lack of established treatments for consistently relapsing germ tumor. Therefore, in this phase II study, we evaluated the efficacy and safety nivolumab relapsed tumor.Seventeen adult patients (median age 34 years) with refractory primary tumor after second-line or higher chemotherapy were enrolled. Nivolumab was administered over 30 min at 240 mg/body every 2 weeks until disease progression intolerable adverse event...
Solitary fibrous tumors (SFT) are mesenchymal neoplasms with a favorable prognosis usually originating from the visceral pleura. Rarely, they may occur at various extrapleural sites and show malignant behavior coupled dedifferentiation. NAB2-STAT6 fusion gene STAT6 nuclear expression biomarkers for diagnosis of SFT in addition to CD34, Bcl-2, CD99. Furthermore, several reports have shown specific variants loss protein associated malignancy. We report rare case retroperitoneal which rapidly...
To determine the effect of combined androgen blockade with a first-generation anti-androgen on prognoses metastatic hormone-sensitive prostate cancer patients stratified by tumor burden.We retrospectively analyzed cases who were treated deprivation therapy in 2008-2017 at 30 institutions Japan. compare overall survival and progression-free rates castration monotherapy blockade, we carried out Cox proportional hazards regression analysis using both inverse probability treatment weighting...