A5024701252- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Testicular diseases and treatments
- Radiopharmaceutical Chemistry and Applications
- Renal Diseases and Glomerulopathies
- Bladder and Urothelial Cancer Treatments
- Hernia repair and management
- Sarcoma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Urological Disorders and Treatments
- Organ Donation and Transplantation
- Ureteral procedures and complications
- Genetic and Kidney Cyst Diseases
- Immune Response and Inflammation
- Pancreatic and Hepatic Oncology Research
- Neurological Complications and Syndromes
- Bone health and treatments
- Urinary and Genital Oncology Studies
- Reproductive Biology and Fertility
- Pelvic floor disorders treatments
- Multiple and Secondary Primary Cancers
- Sperm and Testicular Function
Numazu City Hospital
2021-2025
Shizuoka General Hospital
2016-2024
Tokyo Women's Medical University
2010-2023
Cleveland Clinic Lerner College of Medicine
2023
Cleveland Clinic
2014-2017
Kitasato University Hospital
2017
Kurashiki Central Hospital
2005-2008
Kyoto University Hospital
2008
Shizuoka City Hospital
2003
Transplantation across blood group antigen and human leukocyte (HLA) barriers are immunologically high risk. Both splenectomy rituximab injection were developed to overcome those immunological barriers. The idea behind these treatments is control B-cell immunity before after renal transplantation antibody production. Between January 2001 December 2004, recipients underwent pretransplant double-filtration plasmapheresis (DFPP) at the time of in ABO-incompatible (ABO-I-SPX; n= 45). From 2005...
Abstract Metastatic burden is a critical factor for therapy decision‐making in metastatic hormone‐sensitive prostate cancer. The present study aimed to identify prognostic factors men with high‐ or low‐metastatic treated primary androgen‐deprivation therapy. included 2450 de novo cancer who were at 30 institutions across Japan between 2008 and 2017. We investigated the value of various clinicopathological parameters progression‐free survival (PFS) overall (OS) patients stratified by low‐...
We have reported that B6.CCR5(-/-) mice reject renal allografts with high serum donor-specific antibody (DSA) titers and marked C4d deposition in grafts, features consistent antibody-mediated rejection (AMR). B6.huCD20/CCR5(-/-) mice, where human CD20 expression is restricted to B cells, rejected A/J by day 26 posttransplant DSA first detected on 5 increased thereafter. Recipient treatment anti-huCD20 mAb prior the transplant weekly up 7 weeks promoted long-term allograft survival (>100...
To elucidate the real-world oncological outcomes of robot-assisted radical prostatectomy (RARP) and effectiveness extended pelvic lymph node dissection (ext-LDN) in RARP era. Data from 8 194 patients who underwent RARP, including age, clinical T stage, prostate-specific antigen (PSA) before prostate cancer diagnosis (initial PSA), follow-up years, biopsied specimen grade group (GG), whether they or not presurgical androgen deprivation therapy, were recorded. Oncological among three risk...
The standard protocol of antibiotic prophylaxis in radical prostatectomy remains to be established. We retrospectively compared the occurrence perioperative infections following between two different protocols prophylaxis.This study included 106 cases retropubic managed on clinical pathways. Two were used otherwise identical Between January and December 2004, 50 patients received a second generation cephem, cefotiam, for 4 days, beginning 30 min before surgery (4-day group), whilst 2004 July...
Laparoscopic living donor nephrectomy (LLDN) is a standard method of nephrectomy. Most cases LLDN are transperitoneal. Retroperitoneal access, however, implies direct approach to the retroperitoneal organs without interfering with any them. Since 2001, we have been trying establish technique retroperitoneoscopic live (RPLDN). To assess safety, feasibility, and usefulness RPLDN, reviewed experience this at our institution.From July 2001 March 2009, 425 patients underwent renal transplantation...
Prolonged cold ischemia storage (CIS) is a leading risk factor for poor transplant outcome. Existing strategies strive to minimize ischemia-reperfusion injury in transplanted organs, yet there need novel approaches improve outcomes of marginal allografts and expand the pool donor organs suitable transplantation. Aquaporins (AQPs) are family water channels that facilitate homeostasis, tissue injury, inflammation. We tested whether inhibition AQP4 improves survival fully MHC-mismatched murine...
To evaluate the association between use of local radiotherapy (RT) with survival patients de novo metastatic prostate cancer and symptomatic events (SLEs).Patients were initially diagnosed 2008 2017 at 30 institutes in Japan. Prostate-specific antigen (PSA) progression-free (PSA-PFS) under initial androgen deprivation therapy overall (OS) was compared receiving RT (RT group) no (no-RT by multivariate Cox proportional hazard analyses. The occurrence rate grade ≥2 SLEs logistic regression...
Abstract The metastatic burden is a critical factor for decision‐making in the treatment of hormone‐sensitive prostate cancer (HSPC). This study aimed to develop and validate novel risk model survival patients with de novo low‐ high‐burden HSPC. retrospective observational included men who were treated primary androgen‐deprivation therapy at 30 institutions across Japan between 2008 2017. We created overall (OS) discovery cohort (n = 1449) stratified by (low vs high) validated its predictive...
Aim: Cutaneous ureterostomy is the least invasive method of urinary diversion, but it carries a risk stomal stenosis. We retrospectively examined long‐term outcome tubeless cutaneous by Toyoda method. Methods: Since 1983, has been performed in 97 patients (169 renal units) with minimum follow up 3 months. The ureteral patency rate was reviewed according to whether type single (one ureter, one stoma) or double‐barrel (two ureters, stoma). Results: After median 23 months (range 169), condition...
Previous studies have reported negative impacts of long-term dialysis on kidney transplantation (KTx) outcomes. However, advances in surgical techniques, immunosuppressive therapies, and post-transplant monitoring led to an impressive increase patient allograft survival. Thus, the number KTx among patients is increasing. We evaluated influence duration outcome living donor KTx. Between January 2000 October 2011, we performed 1098 first from donors adults (>18 years). divided into six groups,...
Objectives To examine the effects of combined treatment with sulfoquinovosylacylpropanediol and X‐ray irradiation on remodeling prostate cancer microenvironment, including angiogenic hypoxic characteristics. Methods Human cells (DU145 PC3) were implanted subcutaneously into right hind legs athymic nude mice. After tumor volume reached 100–300mm 3 , 2mg/kg/day was given intravenously from day0 to day4, exposed 4Gy days0 (for a total 8Gy). Tumors fixed stained for pathological analyses...
To determine the effect of combined androgen blockade with a first-generation anti-androgen on prognoses metastatic hormone-sensitive prostate cancer patients stratified by tumor burden.We retrospectively analyzed cases who were treated deprivation therapy in 2008-2017 at 30 institutions Japan. compare overall survival and progression-free rates castration monotherapy blockade, we carried out Cox proportional hazards regression analysis using both inverse probability treatment weighting...
Abstract Recipients of spousal donor transplantation (SDT) have poorer histocompatibility and higher human leukocyte antigen (HLA) sensitization due to pregnancy than those receiving related (RDT). Thus, SDT carries a risk acute rejection (AR). In our department, patients at high immunological risk, such as with ABO incompatibility HLA sensitization, were considered for desensitization by double filtration plasmapheresis preoperative administration rituximab. this study we compared the AR...
A 74-year-old man presented at our hospital with complaints of abdominal pain, nausea, and vomiting. He had undergone laparoscopic radical cystectomy ileal conduit for urinary bladder cancer 1 month earlier. The patient distention, resonant sounds on percussion, diffuse tenderness without rebound or guarding. Abdominal CT revealed dilated jejunal loops herniated through a cord-like structure. Based these findings, emergency surgery was performed, intestinal dilatation into the space between...