A5051622798- IgG4-Related and Inflammatory Diseases
- Barrier Structure and Function Studies
- Risk and Safety Analysis
- Neuroendocrine Tumor Research Advances
- Salivary Gland Tumors Diagnosis and Treatment
- Occupational Health and Safety Research
- Gastrointestinal disorders and treatments
- Cancer-related molecular mechanisms research
- Human-Automation Interaction and Safety
- Head and Neck Surgical Oncology
- Vascular Malformations and Hemangiomas
- Ear and Head Tumors
- Hearing Loss and Rehabilitation
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Tracheal and airway disorders
- Soft tissue tumor case studies
- Congenital Ear and Nasal Anomalies
- Connexins and lens biology
- Nasal Surgery and Airway Studies
- Asthma and respiratory diseases
- Ear Surgery and Otitis Media
- Head and Neck Cancer Studies
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
Sapporo Medical University
2016-2025
Sapporo University
2025
Kitakyushu City Hospital Organization
2018-2024
Sapporo Medical University Hospital
2015-2023
University of Tokyo Hospital
2022
Keio University
2010-2021
Google (United States)
2021
Charité - Universitätsmedizin Berlin
2017
New York Academy of Sciences
2017
John Wiley & Sons (United States)
2017
Summary Background Interleukin ( IL )‐33 is a novel member of the ‐1 cytokine family and ligand for orphan receptor ST 2. The ‐33 induces T helper 2‐type inflammatory responses considered to play crucial rule in allergic inflammations, such as asthma atopic dermatitis. However, role its 2 rhinitis remains unknown. Objective We investigated expression nasal epithelium patients with mechanisms production cytokines/chemokines induced by treatment using normal human epithelial cells HNEC s)...
IgG4-related disease (IgG4-RD) is a novel entity that includes Mikulicz's disease, autoimmune pancreatitis (AIP), and many other conditions. It characterized by elevated serum IgG4 levels abundant IgG4-bearing plasmacyte infiltration of involved organs. We postulated high would comprise useful diagnostic tool, but little information available about in conditions than IgG4-RD, including rheumatic diseases. Several reports have described cutoff values for when diagnosing these studies mostly...
IgG4-related disease (IgG4-RD) is a novel entity that includes Mikulicz's disease, autoimmune pancreatitis (AIP), and many other conditions. It characterized by elevated serum IgG4 levels abundant IgG4-bearing plasmacyte infiltration of involved organs. We postulated high would comprise useful diagnostic tool, but little information available about in conditions than IgG4-RD, including rheumatic diseases. Several reports have described cutoff values for when diagnosing these studies mostly...
Objective. Immunoglobulin (Ig)G4-related disease (IgG4-RD) is a new entity that has only been identified this century. Clinical information thus lacking. We established the Sapporo Medical University and Related Institutes Database for Investigation Best Treatments of IgG4-related Disease (SMART) to clarify clinical features IgG4-RD provide useful clinicians. Methods. Participants comprised 122 patients with dacryoadenitis and/or sialadenitis (IgG4-DS), representing lacrimal salivary lesions...
Allergic rhinitis (AR), the most common allergic disorder of airway, is often accompanied by bronchial asthma. However, little known about mechanism which AR advances to comorbid with asthma (AR + Asthma). To determine pathophysiologic features and Asthma, we examined subsets follicular helper T (Tfh) cells regulatory B (Breg) in peripheral blood from Asthma patients. The results showed polarization Tfh2 within Tfh cell both cases. Interestingly, %Breg total were decreased cases and, more...
The epithelial barrier of the upper respiratory tract plays a crucial role in host defense. In this study, to elucidate whether there is antigen monitoring by dendritic cells (DCs) beyond tight-junction allergic rhinitis, we investigated expression and function tight junctions characterized DCs epithelium nasal mucosa from patients with rhinitis. reverse transcription-polymerase chain reaction, mRNAs proteins occludin, JAM-1, ZO-1, claudin-1, −4, −7, −8, −12, −13, −14 were detected mucosa....
Pseudomonas aeruginosa causes chronic respiratory disease, and the elastase enzyme that it produces increases permeability of airway epithelial cells owing to disruption tight junctions. P. is also implicated in prolonged rhinosinusitis. However, effects (PE) against barrier formed by human nasal (HNECs) remain unknown. To investigate mechanisms involved junctions PE HNECs, primary cultures HNECs transfected with telomerase reverse transcriptase (hTERT-HNECs) were used. The hTERT-HNECs...
IgG4-related disease (IgG4-RD) is a newly recognized systemic chronic fibroinflammatory disease. However, the pathogenesis of IgG4-RD remains unknown. To determine pathophysiologic features IgG4-RD, we examined T follicular helper (Tfh) cells in lesions and blood from patients with IgG4-RD. Patients dacryoadenitis sialadenitis (IgG4-DS) showed increased infiltration Tfh highly expressing programmed death 1 ICOS submandibular glands. IgG4-DS glands had higher expression B cell lymphoma 6...
Abstract Background/Aims: Transforming growth factor‐β (TGF‐β) initiates and maintains epithelial–mesenchymal transition (EMT), which causes disassembly of tight junctions loss epithelial cell polarity. In mature hepatocytes during EMT induced by TGF‐β, changes in the expression junction proteins fence function indicated that polarity remains unclear. Methods: present study, using primary cultures adult rat at day 10 after plating, is well maintained junctions, we examined effects 0.01–20...
IgG4-related disease (IgG4-RD) is a chronic fibroinflammatory characterized by elevation of serum IgG4 level as well infiltration IgG4+ plasma cells in various affected organs. The etiology IgG4-RD still not fully understood. Since more prevalent the elderly, aging itself considered to be an important risk factor IgG4-RD. However, relationship between pathogenesis and immunosenescence remains unknown. To clarify age-related features underlying IgG4-RD, we focused on T follicular regulatory...
Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory condition of unknown etiology characterized by lymphocytic infiltration, fibrosis, and infiltration IgG4-positive plasma cells. It affects various organs, including the pancreas salivary glands. Immunological abnormalities are suspected to play role in its pathogenesis, there an epidemiological link allergic conditions type 2 inflammation. This study focused on expression thymus activation-regulated chemokine (TARC)/CCL17,...
Objectives: Immunoglobulin G4-related disease (IgG4-RD) is a systemic entity characterized by elevated serum IgG4 and extensive IgG4-positive plasma cell infiltration of various organs. Patients with IgG4-RD show nasal manifestations chronic rhinosinusitis. The objective this study was to evaluate the clinical characteristics sinonasal lesions in patients IgG4-RD. Methods: We evaluated radiological findings 79 who were divided into 3 groups according severity. also compared serological...
Abstract Lipolysis-stimulated lipoprotein receptor (LSR) is a unique molecule of tricellular contacts normal and cancer cells. We investigated how the loss LSR induced cell migration, invasion proliferation in endometrial line Sawano. mRNAs amphiregulin (AREG) TEA domain family member 1 (TEAD1) were markedly upregulated by siRNA-LSR. In tissues, downregulation upregulation AREG observed together with malignancy, Yes-associated protein (YAP) was present nuclei. siRNA-AREG prevented migration...
The aim was to study the pathological role of lymphocytes with a peripheral T helper-cell-like phenotype (PD-1+CXCR5−CD4+) in IgG4-related disease (IgG4-RD). PD-1+CXCR5−CD4+ cells blood patients IgG4-RD (n = 53), SS 16) and healthy volunteers 34) as controls were analysed by flow cytometry. Correlations between results obtained cytometry clinical parameters relevant also analysed. percentage absolute number PD-1+CXCR5− within total CD4+ significantly increased compared those volunteers....
Tumor angiogenesis is an important therapeutic target in colorectal cancer (CRC). We aimed to identify novel genes associated with CRC. Using RNA sequencing analysis normal and tumor endothelial cells (TECs) isolated from primary CRC tissues, we detected frequent upregulation of adipocyte enhancer-binding protein 1 (AEBP1) TECs. Immunohistochemical revealed that AEBP1 upregulated TECs stromal tissues. Quantitative RT-PCR showed there little or no expression cell lines, but well expressed...
In human head and neck squamous cell carcinoma (HNSCC), the invasion metastatic properties of cancer cells are promoted by junctional adhesion molecule‑A (JAM‑A) claudin‑1; these epithelial tight junction molecules regulated histone deacetylases (HDACs) transcription factor p63. HDAC expression is reportedly upregulated in HNSCC, inhibitors suppress proliferation initiating proliferative arrest or apoptosis. However, little known anti‑cancer mechanisms HNSCC. Thus, present study, HNSCC...
Humoral immunity is vital for host protection, yet aberrant antibody responses can trigger harmful inflammation and immune-related disorders. T follicular helper (Tfh) cells, central to humoral immunity, have garnered significant attention unraveling immune mechanisms. This study shows the role of B-cell Oct-binding protein 1 (Bob1), a transcriptional coactivator, in Tfh cell regulation. Our investigation, utilizing conditional Bob1-deficient mice, suggests that Bob1 plays critical...