A5103042688- Barrier Structure and Function Studies
- Cancer-related molecular mechanisms research
- Topic Modeling
- Neurological Disease Mechanisms and Treatments
- Connexins and lens biology
- Gut microbiota and health
- Natural Language Processing Techniques
- Caveolin-1 and cellular processes
- Semantic Web and Ontologies
- Information Retrieval and Search Behavior
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Advanced Text Analysis Techniques
- Web Data Mining and Analysis
- Language, Metaphor, and Cognition
- Heme Oxygenase-1 and Carbon Monoxide
- Biomedical Text Mining and Ontologies
- Speech and dialogue systems
- Drug Transport and Resistance Mechanisms
- Renal cell carcinoma treatment
- Estrogen and related hormone effects
- Immune Response and Inflammation
- Recommender Systems and Techniques
- Text and Document Classification Technologies
- Ferroptosis and cancer prognosis
Niigata University
2018-2025
Niigata Prefectural Central Hospital
2025
National Institute of Technology, Toyota College
2024
Sapporo Medical University
2012-2023
Molecular Oncology (United States)
2023
Tokeidai Memorial Hospital
2021-2023
Niigata University Medical and Dental Hospital
2018-2022
Aoyama Gakuin University
2021
Japan University of Economics
2020
Memorial Hospital
2020
The epithelial barrier of the upper respiratory tract plays a crucial role in host defense. In this study, to elucidate whether there is antigen monitoring by dendritic cells (DCs) beyond tight-junction allergic rhinitis, we investigated expression and function tight junctions characterized DCs epithelium nasal mucosa from patients with rhinitis. reverse transcription-polymerase chain reaction, mRNAs proteins occludin, JAM-1, ZO-1, claudin-1, −4, −7, −8, −12, −13, −14 were detected mucosa....
Abstract Occludin is the first identified integral protein for tight junction (TJ), and its long COOH-terminal domain considered to have functions in receiving transmitting cell survival signals. Loss of TJ-associated molecules, such as occludin, has been correlated with tumor progression carcinogenesis; however, precise molecular mechanisms explaining loss expression whether occludin any effects on cancer phenotypes remain be clarified. Here, we show that forced cells exhibits enhanced...
The human nasal epithelium is the first line of defense during respiratory virus infection. Respiratory syncytial (RSV) major cause bronchitis, asthma and severe lower tract disease in infants young children. We previously reported epithelial cells (HNECs), replication budding RSV responses, including release proinflammatory cytokines enhancement tight junctions, are part regulated via an NF-κB pathway. In this study, we investigated effects HNECs infected with RSV. Curcumin prevented...
The failure of normal hematopoiesis is observed in myeloid neoplasms. However, the precise mechanisms governing replacement hematopoietic stem cells their niche by neoplasm have not yet been clarified. Primary acute leukemia and myelodysplastic syndrome induced aberrant expression multiple factors including Jagged-1, cell factor angiopoietin-1 mesenchymal even non-contact conditions, this abnormality was reverted extracellular vesicle inhibition. Importantly, transfer neoplasm-derived...
The epithelial barrier is determined primarily by intercellular tight junctions (TJs). We have demonstrated previously that all-<i>trans</i> retinoic acid (atRA) plays an important role in forming functional TJs through a specific receptor (RAR)/retinoid X heterodimer cells. However, the physiological relevance of acids (RAs) maintaining integrity remains to be examined. Here, we show several types RA, including atRA, promote function TJs. Conversely, RA depletion cells overexpressing...
Abstract Background/Aims: Transforming growth factor‐β (TGF‐β) initiates and maintains epithelial–mesenchymal transition (EMT), which causes disassembly of tight junctions loss epithelial cell polarity. In mature hepatocytes during EMT induced by TGF‐β, changes in the expression junction proteins fence function indicated that polarity remains unclear. Methods: present study, using primary cultures adult rat at day 10 after plating, is well maintained junctions, we examined effects 0.01–20...
Respiratory syncytial virus (RSV) is the major cause of bronchitis, asthma, and severe lower respiratory tract disease in infants young children. The airway epithelium, which has a well-developed barrier regulated by tight junctions, first line defense during infection. In upper human nasal epithelial cells (HNECs), however, primary site RSV infection, mechanisms replication budding RSV, cell responses, including junctional barrier, remain unknown. To investigate detailed HNECs we...
Abstract BACKGROUND Clostridium perfringens enterotoxin (CPE) triggers lysis of epithelial cells through binding to tight‐junction proteins claudin‐3 (Cldn3) and Cldn4, which are over‐expressed in prostate cancer. We investigated the potential Cldn‐targeted therapy using CPE. METHODS expression levels subcellular localization Cldn3 Cldn4 primary human cancer tissues, cell lines (22Rv1, DU145, PC3) normal (PrECs). Cytotoxic effects CPE on these were examined by colorimetric assay. studied...
Abstract Recent studies have revealed that metabolic reprogramming is closely associated with epithelial‐mesenchymal transition (EMT) during cancer progression. Aldolase A (ALDOA) a key glycolytic enzyme highly expressed in several types of cancer. In this study, we found ALDOA uterine cervical adenocarcinoma and high expression promotes EMT to increase malignant potentials, such as metastasis invasiveness, cells. human surgical specimens, was correlated lymph node metastasis, lymphovascular...
ABSTRACT Introduction We report a case of perianal abscess that developed after the presence urethral foreign body for 15 months. Case Presentation A 14‐year‐old boy with intellectual disability due to agenesis corpus callosum presented our hospital complaints erythema, swelling, and pain. The patient admitted self‐inserting an allene fiber broom ear months ago. few days insertion, he was treated antibiotics hematuria micturition symptoms resolved spontaneously 2 later, although not removed....
Abstract Background Automated information extraction from biomedical literature is important because a vast amount of has been published. Recognition the named entities first step in extraction. We developed an automated recognition system based on SVM algorithm and evaluated it Task 1.A BioCreAtIvE, competition for gene/protein name recognition. Results In work presented here, our uses feature set word, part-of-speech (POS), orthography, prefix, suffix, preceding class. call these features...
Cancer cells often exhibit loss of functional tight junctions (TJ), and disruption the TJ structure is associated with cancer development. However, whether a certain type claudin, an integral membrane protein TJ, involved in malignant phenotypes remains to be clarified. Based on report that claudin‐6 functions as tumor suppressor for breast cancer, authors show here suppression expression results increased resistance various apoptogens, causally enhances anchorage‐independent growth...
The epithelium of upper respiratory tissues such as human nasal mucosa forms a continuous barrier via tight junctions, which is thought to be regulated in part through protein kinase C (PKC) signaling pathway. To investigate the mechanisms regulation PKC-mediated junction function detail, primary epithelial cells were treated with PKC activator 12-<i>O</i>-tetradecanoylophorbol-13-acetate (TPA). In cells, treatment TPA led not only activation phosphorylation PKC, myristoylated alanine-rich...