A5028797939- IgG4-Related and Inflammatory Diseases
- T-cell and B-cell Immunology
- Neuroendocrine Tumor Research Advances
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal disorders and treatments
- IL-33, ST2, and ILC Pathways
- Aortic aneurysm repair treatments
- Atherosclerosis and Cardiovascular Diseases
- Platelet Disorders and Treatments
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Otitis Media and Relapsing Polychondritis
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Hidradenitis Suppurativa and Treatments
Sapporo Medical University
2018-2025
IgG4-related disease (IgG4-RD) is a chronic fibroinflammatory characterized by elevation of serum IgG4 level as well infiltration IgG4+ plasma cells in various affected organs. The etiology IgG4-RD still not fully understood. Since more prevalent the elderly, aging itself considered to be an important risk factor IgG4-RD. However, relationship between pathogenesis and immunosenescence remains unknown. To clarify age-related features underlying IgG4-RD, we focused on T follicular regulatory...
The aim was to study the pathological role of lymphocytes with a peripheral T helper-cell-like phenotype (PD-1+CXCR5−CD4+) in IgG4-related disease (IgG4-RD). PD-1+CXCR5−CD4+ cells blood patients IgG4-RD (n = 53), SS 16) and healthy volunteers 34) as controls were analysed by flow cytometry. Correlations between results obtained cytometry clinical parameters relevant also analysed. percentage absolute number PD-1+CXCR5− within total CD4+ significantly increased compared those volunteers....
Humoral immunity is vital for host protection, yet aberrant antibody responses can trigger harmful inflammation and immune-related disorders. T follicular helper (Tfh) cells, central to humoral immunity, have garnered significant attention unraveling immune mechanisms. This study shows the role of B-cell Oct-binding protein 1 (Bob1), a transcriptional coactivator, in Tfh cell regulation. Our investigation, utilizing conditional Bob1-deficient mice, suggests that Bob1 plays critical...
Background Chronic inflammation is involved in the development of abdominal aortic aneurysm (AAA). A tertiary lymphoid structure (TLS) within vascular lesions has recently been focused on for its role modulation local tissues. We aimed to elucidate relationships between TLS and pathophysiology AAA. Methods Abdominal samples obtained from 37 patients with AAA (men/women: 34/3, age: 72.8±9.9 years) 15 autopsied who died non‐aortic events 11/4, 65.5±9.8 were investigated. Results TLSs confirmed...
Objectives: The aim of this study was to determine pathological features T peripheral helper (Tph)-like (PD-1+CXCR5−CD4+ T) cells in IgG4-related disease (IgG4-RD).Methods: Tph-like the...
T follicular helper (Tfh) cells drive humoral immunity by facilitating B cell responses at the initial and recall phases. Recent studies have indicated possible involvement of Tfh in process chronic inflammation. However, functional role persistent immune settings remains unclear. Here, we report that CD4 + CD8 (double-positive, DP; CD3 CXCR5 hi PD-1 ) cells, a subset germinal-center-type were abundantly present fibroinflammatory lesions patients with immunoglobulin G4-related disease...
CXCR5+ T follicular helper (TFH) cells primarily promote B to produce an antigen-specific antibody through germinal centers (GCs). TFH exist in circulation, and circulating(c) TFH2 cells, a subset of cTFH are able help naïve IgE healthy individuals. Conversely, IL-10-producing regulatory (Breg) inhibit accelerated immune response.We investigated the roles cBreg based on TH2 response patients with atopic asthma (AA). Thirty-two AA 35 volunteers (HV) were enrolled. We examined including their...
Antigen-specific humoral responses are orchestrated through complex interactions among immune cells in lymphoid tissues, including the collaboration between B and T follicular helper (Tfh) cells. Accumulating evidence indicates a crucial role for interleukin-9 (IL-9) formation of germinal centers (GCs), enhancing generation class-switched high-affinity antibodies. However, exact function IL-9 Tfh cell regulation remains unclear. In this study, we examined CD4 Cre/+ Il9ra fl/fl mice, which...
Complex interactions between keratinocytes and various cell types, such as inflammatory cells stromal cells, contribute to the pathogenesis of chronic skin lesions. In proinflammatory cytokine‒mediated disease settings, IL-9 plays a pathological role in dermatitis. However, IL-9‒related mechanisms remain incompletely understood. this study, we established tamoxifen-induced keratinocyte-specific IL-9RA-deficient mice (K14CRE/ERTIl9raΔ/Δ mice) examine multicellular under conditions. Studies...
The relationships between T follicular helper (Tfh) cells and antigen-specific immunoglobulins (sIgs) in patients with allergic respiratory diseases who are receiving antigen immunotherapy (AIT) have not been fully clarified. Therefore, we started to perform house dust mite sublingual (HDM-SLIT) for 20 atopic asthma comorbid rhinitis (AA+AR) were already ordinary treatments including inhaled corticosteroid (ICS). We examined percentages of circulating (cTfh) regulatory (cTfr) (cTreg) B...