A5001535116- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inhalation and Respiratory Drug Delivery
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Neonatal Respiratory Health Research
- Occupational and environmental lung diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Pulmonary Hypertension Research and Treatments
- Occupational exposure and asthma
- Drug-Induced Adverse Reactions
- Pneumonia and Respiratory Infections
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Systemic Sclerosis and Related Diseases
- IL-33, ST2, and ILC Pathways
- Tracheal and airway disorders
- Inflammatory Myopathies and Dermatomyositis
- Pneumocystis jirovecii pneumonia detection and treatment
- Salivary Gland Tumors Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Peptidase Inhibition and Analysis
- Allergic Rhinitis and Sensitization
- Tuberculosis Research and Epidemiology
Sapporo Medical University
2016-2025
Hakodate National Hospital
2023
Sapporo Kosei General Hospital
2005
Objective . Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a rare disease characterized by predominant upper lobe pulmonary fibrosis of unknown etiology. However, the prognosis IPPFE has not been discussed. We investigated clinical characteristics and prognostic factors idiopathic (IPF). Methods performed retrospective cohort study on 375 consecutive interstitial pneumonia patients between April 2004 December 2014. Among them, we diagnosed IPF using high-resolution computed...
Smoking may have multifactorial effects on asthma phenotypes, particularly in severe asthma. Cluster analysis has been applied to explore novel which are not based any a priori hypotheses.To phenotypes by cluster when including smoking patients with asthma.We recruited total of 127 subjects asthma, 59 current or ex-smokers, from our university hospital and its 29 affiliated hospitals/pulmonary clinics. Clinical variables obtained during 2-day stay were used for analysis. After clustering...
T follicular helper (Tfh) cells have been identified as a new category of cells, which express CXCR5 on their surface and induce the production antigen-specific antibodies. Many investigations found morbid proliferation and/or activation Tfh in systemic autoimmune allergic diseases. It is also known that are regulated by regulatory B (Breg) deteriorating such Recently, CXCL13, ligand CXCR5, has reported to increase peripheral blood lungs patients with idiopathic pulmonary fibrosis (IPF)....
Background Antifibrotic therapies are available to treat chronic fibrosing interstitial lung diseases (CF-ILDs), including idiopathic pulmonary fibrosis. Early use of these treatments is recommended slow deterioration respiratory function and prevent acute exacerbation. However, identifying patients in the early stages CF-ILD using chest radiographs challenging. In this study, we developed tested a deep-learning algorithm detect radiograph images. Method From image archive Sapporo Medical...
Humoral immunity is vital for host protection, yet aberrant antibody responses can trigger harmful inflammation and immune-related disorders. T follicular helper (Tfh) cells, central to humoral immunity, have garnered significant attention unraveling immune mechanisms. This study shows the role of B-cell Oct-binding protein 1 (Bob1), a transcriptional coactivator, in Tfh cell regulation. Our investigation, utilizing conditional Bob1-deficient mice, suggests that Bob1 plays critical...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive and fibrosing lung disease with poor prognosis. Pirfenidone nintedanib are anti-fibrotic drugs used for patients IPF. These reduce the rate of decline in forced vital capacity (FVC). Serum surfactant protein (SP)-A, SP-D, Krebs von den Lungen-6 (KL-6) monitoring prognostic biomarkers IPF; however, their relationship therapeutic outcomes has not been investigated. We aim to clarify whether serum SP-A, KL-6 reflect...
Surfactant proteins SP-A and SP-D are useful biomarkers in diagnosis, monitoring, prognosis of idiopathic pulmonary fibrosis (IPF). Despite their high structural homology, serum concentrations often vary IPF patients. This retrospective study aimed to investigate distinct compartmentalization the vasculature lungs by bronchoalveolar lavage fluid (BALF)/serum analysis, hydrophilicity immunohistochemistry.We included 36 patients, 18 sarcoidosis (SAR) patients 20 healthy subjects. Low-speed...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with variable disease course. The recent advancement of antifibrotic therapy has increased the need for reliable and specific biomarkers. This study aimed to assess alveolar epithelial biomarkers as predictors efficacy drug pirfenidone. Methods We conducted post-hoc analysis prospective, multicenter, randomized, placebo-controlled, phase 3 trial pirfenidone in Japan (total, n = 267; pirfenidone, 163;...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor prognosis. Pulmonary function tests (PFTs) aid in evaluating the status of IPF. The clinical significance oscillometry measurements interstitial lung diseases has recently been reported. Our previous study showed that respiratory reactance (Xrs) measured by reflected severity and predicted subsequent capacity decline patients However, direct impact Xrs on survival needs to be determined, there are...
Abstract Objective Rapid on‐site cytological evaluation ( ROSE ) in bronchoscopy is a useful ancillary technique. usually performed by cytopathologist or cytotechnologist. However, because of staff shortages and reduced availability, cannot be every hospital. We aimed to evaluate the accuracy when trained pulmonologist, comparing diagnosis results with final cytopathologists. Methods retrospective cohort study on 125 patients who underwent endobronchial ultrasound‐guided transbronchial...
CXCR5+ T follicular helper (TFH) cells primarily promote B to produce an antigen-specific antibody through germinal centers (GCs). TFH exist in circulation, and circulating(c) TFH2 cells, a subset of cTFH are able help naïve IgE healthy individuals. Conversely, IL-10-producing regulatory (Breg) inhibit accelerated immune response.We investigated the roles cBreg based on TH2 response patients with atopic asthma (AA). Thirty-two AA 35 volunteers (HV) were enrolled. We examined including their...
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease. Although function test (PFT) useful for evaluating the progression of IPF, obtaining adequate results in advanced cases can be challenging. Conversely, forced oscillation technique (FOT) noninvasively performed, even patients with severely deteriorated lung function. In this study, usefulness FOT evaluation IPF disease status was investigated. We analyzed PFT and data 97 IPF. The respiratory reactance (Xrs) components FOT,...
Abstract SMARCA4‐deficient undifferentiated tumor (SMARCA4‐UT) is a high‐grade malignant neoplasm showing or rhabdoid morphology that significantly involves the thorax of adults. It has been reported as thoracic sarcoma non‐small cell lung carcinoma according to findings immunohistochemical and genetic studies. We report case SMARCA4‐UT for which block analysis staining were useful final diagnosis. A 51‐year‐old man had chief complaint left back pain visited our hospital further examination....
Here, we report two cases of patients with interstitial pneumonia (IP) on steroids who developed Pneumocystis jirovecii (PJP) following coronavirus disease 2019 (COVID-19) infection. Case 1: A 69-year-old man 10 mg prednisolone (PSL) daily for IP new shortly after his COVID-19 infection improved and was diagnosed PJP based chest computed tomography (CT) findings elevated serum β-D-glucan levels. Trimethoprim-sulfamethoxazole (TMP-SMZ) administered, the resolved. 2: 70-year-old woman taking 4...
The lung-specific soluble lectins, SP-A and SP-D have been clinically used to diagnose interstitial lung disease, but their clinical significance in COVID-19 remains controversial. This study was undertaken determine association with other lectins (MBL FCN1), disease severity, radiographs patients.A total of 131 patients admitted the Sapporo Medical University Hospital between May 22 September 19, 2021, were enrolled study. Data including demographics, medical history, symptoms, signs,...
To investigate the effectiveness of BMAX, a deep learning-based computer-aided detection system for detecting fibrosing interstitial lung disease (ILD) on chest radiographs among non-expert and expert physicians in real-world clinical setting. Retrospective, observational study. This study used radiograph images consecutively taken three medical facilities with various degrees referral. Three ILD interpreted each image determined whether it was ILD-suspected (fibrosing positive) or not...
This study investigated the utility of periostin, a matricellular protein, as prognostic biomarker in patients with idiopathic pulmonary fibrosis (IPF) who received nintedanib. Monomeric and total periostin levels were measured by enzyme-linked immunosorbent assay 87 eligible participated multicenter prospective study. Forty-three antifibrotic drug-naive IPF described previous studies set historical controls. not significantly associated change forced vital capacity (FVC) or diffusing lungs...
A paradoxical reaction during antituberculosis treatment is defined as the worsening of pre-existing tuberculosis lesions or appearance a new lesion in patients whose clinical symptoms improved with treatment. The median onset time to development response has been reported be about 60 days after start We report case patient presenting psoas abscess nine months To best our knowledge, this manifestation not previously reported. 23-year-old Japanese man presented hospital lower abdominal pain....