A5062875315- Atmospheric aerosols and clouds
- Neonatal Respiratory Health Research
- Atmospheric chemistry and aerosols
- Ionosphere and magnetosphere dynamics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mycobacterium research and diagnosis
- Inhalation and Respiratory Drug Delivery
- Glioma Diagnosis and Treatment
- Asthma and respiratory diseases
- GNSS positioning and interference
- Intracranial Aneurysms: Treatment and Complications
- Composite Structure Analysis and Optimization
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Imaging and Pathology Studies
- Engineering Applied Research
- Tracheal and airway disorders
- Pneumonia and Respiratory Infections
- Meningioma and schwannoma management
- Structural Load-Bearing Analysis
- Fatigue and fracture mechanics
- Sensor Technology and Measurement Systems
- Vascular Malformations Diagnosis and Treatment
- Analytical Chemistry and Sensors
- Respiratory and Cough-Related Research
- Glycosylation and Glycoproteins Research
Sapporo Medical University
2016-2025
Hirosaki University
2022-2025
Astellas Pharma (Japan)
2024
Meteorological Research Institute
2010-2024
Hirosaki University Hospital
2024
JVC Kenwood (Japan)
2022-2023
Kanazawa Medical University
2003-2022
Sendai Medical Center
2018-2022
National Hospital Organization
2022
Ueno Gakuen University
2022
Abstract. Immersion freezing is the most relevant heterogeneous ice nucleation mechanism through which crystals are formed in mixed-phase clouds. In recent years, an increasing number of laboratory experiments utilizing a variety instruments have examined immersion activity atmospherically ice-nucleating particles. However, intercomparison these results difficult task because investigators used different (IN) measurement methods to produce results. A remaining challenge explore sensitivity...
Abstract The COVID-19 pandemic has created urgent demand for rapid detection of the SARS-CoV-2 coronavirus. Herein, we report highly sensitive nucleocapsid protein (N protein) using nanoparticle-enhanced surface plasmon resonance (SPR) techniques. A crucial plasmonic role in significantly enhancing limit (LOD) is revealed exceptionally large gold nanoparticles (AuNPs) with diameters hundreds nm. SPR enhanced by these lowered LOD N to 85 fM, resulting highest sensitivity ever obtained protein.
Abstract. We present the laboratory results of immersion freezing efficiencies cellulose particles at supercooled temperature (T) conditions. Three types chemically homogeneous samples are used as surrogates that represent supermicron and submicron ice-nucleating plant structural polymers. These include microcrystalline (MCC), fibrous (FC) nanocrystalline (NCC). Our dataset includes data from various ice nucleation measurement techniques available 17 different institutions, including nine...
Idiopathic pulmonary fibrosis (IPF) is the most frequent and severe form of idiopathic interstitial pneumonias. Although IPF has not been thought to be associated with bacterial communities, recent papers reported possible role microbiome composition in IPF. The roles microbiomes respiratory functions as clinical biomarkers for remain unknown. In this study, we aim identify relationship between microbial environment lung findings. Thirty-four subjects diagnosed were included analysis. 16S...
Epithelial deletion of Npt2b results in a tractable mimic pulmonary alveolar microlithiasis.
BACKGROUND Cases of congenital disorders glycosylation (CDGs) are rare, and the occurrence hemorrhagic infarction is also rare. The etiology unclear. OBSERVATIONS A 3-year-old Asian boy with CDG type 1A was hospitalized pneumonia. Consciousness disturbance hemiplegia appeared after high fever were associated disseminated intravascular coagulation. Magnetic resonance (MR) images showed subcortical due to anterior superior sagittal sinus occlusion. Follow-up computed tomography revealed...
Bacteria continually evolve. Previous studies have evaluated bacterial evolution in retrospect, but this approach is based on only speculation. Cohort are reliable require a long duration. Additionally, identifying which genetic mutations that emerged during possess functions of interest to researchers an exceptionally challenging task. Here, we establish Rapid and Integrated Bacterial Evolution Analysis (RIBEA) serial passaging experiments using hypermutable strains, whole-genome...
Significance Influenza is a recurring global health threat that preferentially targets vulnerable groups such as the very young, pregnant, elderly, and infirm. The spread of influenza A virus (IAV) from epithelium conducting airway to alveolar pivotal event in pathogenesis primary viral pneumonia. Host susceptibility IAV pneumonia often attributed altered immunity, cell autonomous vulnerability states epithelium, proliferative tone, are rarely considered. Here we demonstrate mitogenic...
Background Superficial temporal artery (STA) aneurysms are relatively rare diseases, and the treatment approach is based on factors such as location of aneurysm, curability, complications, patient request. However, detailed outcome STA treated with endovascular surgery remains unknown. Case Description A 75-year-old woman found a pulsatile mass lesion at preauricular region gradual enlargement. Angiography showed thrombosed aneurysm originating from STA. Endovascular trapping was selected...
Absorption, infrared reflection absorption (IRA), and resonance Raman scattering (RRS) spectroscopies were applied to obtain direct information about the conformation change of a polydiacetylene (abbreviated PDA) produced by UV irradiation Langmuir−Blodgett (LB) films cadmium salt diacetylene derivative, 10,12-pentacosadiynoic acid (DA), with number monolayers from 1 31. The rate extent polymerization DA monitored relative intensity IRA bands due C⋮C stretching vibrations correlated...
Pulmonary collectins, surfactant proteins A (SP-A) and D (SP-D), play important roles in innate immunity of the lung. Legionella pneumophila is a bacterial respiratory pathogen that can replicate within macrophages causes opportunistic infections. L. possesses cytolytic activity, resulting from insertion pores macrophage membrane upon contact. We examined whether pulmonary collectins protective against infection. SP-A SP-D bound to its lipopolysaccharide (LPS) inhibited growth...
Abstract Background: COVID-19 is currently undergoing a pandemic worldwide, including in Japan, and many lives have been lost. So, there an urgent need to develop new biomarkers for estimating progression or prognosis of patient. Lung-specific serum biomarkers, SP-A, SP-D KL-6 used clinically diagnosis interstitial lung disease (ILDs), but their use has not investigated. To determine whether levels correlate with the severity as indicated by clinical symptoms radiological findings. Methods:...
MET, the receptor for hepatocyte growth factor (HGF), is strongly associated with resistance to tyrosine kinase inhibitors, key drugs that are used in therapy of non-small cell lung cancer. MET contains 11 potential N-glycosylation sites, but site-specific roles these N-glycans have not been elucidated. We report herein regulate proteolytic processing and HGF-induced signaling, this regulation site specific. Inhibitors were found suppress trafficking endogenous H1975 EBC-1 cancer cells...
AimsThe prevalence, clinical significance, and pathogenesis of J-waves were studied in the patients with an ST-elevation myocardial infarction (MI) after percutaneous coronary intervention (PCI).
A new cloud simulation chamber was built at the Meteorological Research Institute (MRI) to investigate details of fundamental processes formation. The MRI designed as an adiabatic-expansion-type covering temperatures from 30 −100°C, pressures 1030 hPa, and evacuation rates corresponding ascent 0 m s−1. Improvements cooling system characterization instrumentation distinguish facility past devices this type that are no longer functional (e.g., Colorado State University dynamic chamber),...
Keratinocyte growth factor (KGF) is an epithelial mitogen that has been reported to protect the lungs from a variety of toxic and infectious insults. In prior studies we found recombinant human KGF accelerates clearance bacteria murine lung by augmenting function alveolar macrophages (AM). this study tested hypothesis endogenous plays role in maintenance innate pulmonary defense against gram-negative bacterial infections. KGF-deficient mice exhibited delayed Escherichia coli lungs,...
The adherence of uropathogenic Escherichia coli (UPEC) to the host urothelial surface is first step for establishing UPEC infection. Uroplakin Ia (UPIa), a glycoprotein expressed on bladder urothelium, serves as receptor FimH, lectin located at bacterial pili, and their interaction initiates Surfactant protein D (SP-D) known be mucosal surfaces in various tissues besides lung. However, functions SP-D non-pulmonary are poorly understood. purposes this study were investigate possible function...