A5100427547- Gut microbiota and health
- Plant Reproductive Biology
- Probiotics and Fermented Foods
- Immunotherapy and Immune Responses
- Horticultural and Viticultural Research
- Fermentation and Sensory Analysis
- CRISPR and Genetic Engineering
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Barrier Structure and Function Studies
- Immune Cell Function and Interaction
- Plant Molecular Biology Research
- Plant Physiology and Cultivation Studies
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Infant Nutrition and Health
- Natural Compound Pharmacology Studies
- Cassava research and cyanide
- Traditional Chinese Medicine Analysis
- Acupuncture Treatment Research Studies
- Lymphoma Diagnosis and Treatment
- Food Waste Reduction and Sustainability
- Bioenergy crop production and management
- Proteoglycans and glycosaminoglycans research
Central South University
2025
The University of Tokyo
2025
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Northwest A&F University
2022-2024
Megmilk Snow Brand (Japan)
2024
Morinaga (Japan)
2024
Harvard University
2022-2023
UNSW Sydney
2023
Hainan University
2022
Within 1 wk of liquid culture in granulocyte/macrophage colony-stimulating factor (GM-CSF), normal B10 BR (H-2k I-E+) mouse liver nonparenchymal cells (NPC) formed loosely adherent myeloid cell clusters that have been shown to contain dendritic (DC) progenitors similar studies blood or bone marrow. Mononuclear progeny released from these at and beyond 4 d exhibited distinct morphology were actively phagocytic. After 6-10 culture, strongly expressed CD45, CD11b, heat stable antigen, CD44....
Mutations in Atp2b2, an outer hair cell gene, cause dominant hearing loss humans. Using a mouse model Atp2b2
Conflicting data have been reported with regard to the infectability, dysfunction, and depletion of dendritic cells (DCs) in human immunodeficiency virus (HIV) disease. These discrepancies could potentially be explained by existence multiple subsets morphology peripheral blood. The isolation DCs humans is accomplished through negative selection until a morphologically pure population obtained. Recently, DC precursors purified from blood observed develop into functionally mature DCs. In this...
Background Blood-brain barrier (BBB) disruption and gut microbiota dysbiosis play crucial roles in Alzheimer’s disease (AD). Lipopolysaccharide (LPS) stimulation triggered by microbial is an important factor BBB systemic inflammation, but the mechanism of acupuncture regulation via AD not clear. Objective The current study evaluated effect manual (MA) on dysfunction APP/PS1 mice examined AD. Methods Acupoints were applied to Baihui (GV20), Yintang (GV29), Zusanli (ST36) MA group. Mice plus...
The gut-uterus axis plays a pivotal role in the pathogenesis of endometrial cancer (EC). However, correlations between microbiome and tumor transcriptome patients with EC impact microbiota on hematological indicators have not been thoroughly clarified. In this prospective study, tissue samples collected from (n = 30) healthy volunteers 10) were subjected to 16S rRNA sequencing microbiome. 30 paired adjacent nontumor tissues group RNAseq. We found that Pelomonas Prevotella enriched high...
Gut microbiota dysbiosis and intestinal barrier injury play vital roles in Alzheimer's disease (AD) onset development. Our previous studies have demonstrated that manual acupuncture (MA) could improve the cognitive abilities of APP/PS1 mice. However, effect MA on mucosal gut mechanism through which this occurs remain to be clarified.
The changes in intrinsic motivation during engaging activities are important to understand for encouraging ongoing participation, such as research and development within companies where individual commitment is crucial, user-generated content platforms that rely on voluntary user contributions. This study proposes an experimental method derive honest reports of a numerical form from subjects, by combining the free-choice paradigm Becker-DeGroot-Marschak (BDM) mechanism. allows acquisition...
<title>Abstract</title> <bold>Background:</bold> Osteoporosis (OP) is a global health issue. Essential for the metabolism of bone, thyroid function plays crucial role. The connection between hypothyroidism and OP in individuals without cancer remains ambiguous. aim this study was to investigate impact on onset patients who did not have cancer. <bold>Methods:</bold> exposures with non-cancer were obtained from publicly accessible MRC-IEU consortium UK Biobank, while outcomes derived GWAS...
Steroidal glycoalkaloids (SGAs) are cholesterol-derived molecules that contribute to the pathogen defense in tomato but toxic and considered be antinutritional compounds humans. APETALA2/Ethylene Responsive Factor (AP2/ERF) family transcription factors (TFs) play an indispensable role various biological processes, such as plant growth development, fruit ripening, biotic abiotic stresses responses, SGA biosynthesis. In this study, we identified 176 AP2/ERF genes were domesticated or improved...
In this work, 26 methylated acylphloroglucinol meroterpenoids with diverse skeletons, including 18 new ones (bellumones A-R, 1–18), were identified from the flowers of Hypericum bellum. Their structures absolute configurations elucidated by detailed spectroscopic data, calculated electronic circular dichroism (ECD), and X-ray diffraction (XRD). Through methylation at C-5, prenylation different chain lengths acylphloroglucinol-derived core, along types secondary cyclization, type A bicyclic...
Human milk oligosaccharides (HMOs) play key roles in shaping infant fecal microbiota, and HMOs profiles have been reported to vary according the mother's glycosyltransferase phenotype. In this study, of human from secretor or non-secretor mothers collected at 2 months postpartum were analyzed by liquid chromatography quadrupole time-of-flight tandem mass spectrometry. 16S rRNA sequencing was used characterize microbiota breastfed infants. The amount total fucosylated higher than mothers,...
Quorum sensing (QS) is a unique mechanism for microorganisms to coordinate their activities through intercellular communication, including four main types of autoinducer-1 (AI-1, namely, N-acyl homoserine lactone [AHL]), AI-2, AI-3, and diffusible signaling factor [DSF]) based on molecules. quenching (QQ) enzymes can disrupt the QS phenomenon by inactivating proposed regulate biofilm formation in extremely acidic environments, but QS/QQ-related genomic features most acidophilic bacteria are...
Chemoresistance is a significant factor associated with poor outcomes of osteosarcoma patients. The present study aims to identify Chemoresistance-regulated gene signatures and microRNAs (miRNAs) in Gene Expression Omnibus (GEO) database. results Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) included positive regulation transcription, DNA-templated, tryptophan metabolism, the like. Then differentially expressed genes (DEGs) were uploaded Search Tool for Retrieval Interacting (STRING)...
Previous study suggested that dietary intake of Lactobacillus plantarum 06CC2 (LP06CC2) isolated from Mongolian dairy products showed various health beneficial effects. Here, the effect LP06CC2 on cholesterol metabolism in mice fed a cholesterol-loaded diet was evaluated. Cholesterol and were incorporated into AIN93G-based to evaluate Balb/c mice. Serum liver levels significantly increased whereas ingestion suppressed increase cholesterol. hepatic damage indices. The cecal content fecal...
The interaction between the gut microbiota and host can influence host’s immune system. Bifidobacterium, a commensal genus of bacteria, seems to have positive effects on health. Our previous clinical research showed that B. longum subsp. BB536 enhanced innate adaptive responses in elderly individuals with lower grade immunity, but immunomodulatory mechanism is still unclear. In this study, dendritic cell (DC) surface markers peripheral blood mononuclear cells isolated from healthy were...
// Yiran Li 1 , Yuanhui Jia 2 Qi Che Qian Zhou Kai Wang Xiao-Ping Wan 3 Department of Obstetrics and Gynecology, Shanghai First People's Hospital Affiliated to Jiao Tong University, Shanghai, China Clinical Translational Research Center, Maternity Infant Hospital, Tongji University School Medicine, Correspondence to: Wang, e-mail: kaiwangcn@yahoo.com Wan, wanxiaoping62@126.com Keywords: endometrial carcinoma, Autocrine Motility Factor (AMF)/PhosphoGlucose Isomerase (PGI), MAPK signaling...
Ischemic cardiomyopathy (ICM) is an important cause of heart failure, yet no ICM disease genes were stored in any public databases. Mutations provided by RNA-Seq data could set a foundation for variety biological processes. This also made it possible to elucidate the mechanism and identify potential ICM. In this paper, integrated co-expression network was constructed using univariate bivariate canonical correlation analysis human samples. Three ICM-related modules recognized after comparing...
Rootstocks were bred and selected from several species in order to enhance the resistance against biotic or abiotic stresses. There are few studies on effect of rootstocks aroma related gene expression. This study focused effects three rootstocks, Kober 5BB (5BB), 1103 Paulsen (1103P), Selection Oppenheim (SO4), volatile-related expression levels Merlot Marselan berries wines. These reduced total content wine. upregulated VvLoXA showed increased C6 alcohols. 1103P enhanced linalool berry,...
Breast cancer is one of the leading causes mortality in females. A number prognostic markers have been identified, including single genes, multi‑gene signatures and network modules; however, robustness these insufficient. Thus, present study proposed a more robust method to identify breast modules based on weighted protein‑protein interaction networks, by integrating four sets disease‑associated expression profiles. Three identified were closely associated with prognosis‑associated functions...
Abstract Gallbladder carcinoma (GBC) is a malignant hepatobiliary cancer characterized by an intricate tumor microenvironments (TME) and heterogeneity. The traditional GBC 2D culture models cannot faithfully recapitulate the characteristics of TME. Three-dimensional (3D) bioprinting enables establishment high-throughput high-fidelity multicellular models. In this study, we designed concentric cylindrical tetra-culture model to reconstitute spatial distribution cells in tissue, with inner...
As a salt-type compound, mosapride citrate’s metabolism and side effects are correlated with its salt-forming ratio. Several techniques were developed in this work to compare various quantitative nuclear magnetic resonance (qNMR) methodologies quantitatively examine the content of raw materials. Among qNMR techniques, methods for 1H NMR 19F developed. Appropriate solvents chosen, temperature, number scans, acquisition time, relaxation delay parameter settings optimized. Maleic acid was...