A5101553593- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- Ovarian function and disorders
- RNA Research and Splicing
- Renal and related cancers
- Asymmetric Hydrogenation and Catalysis
- Cancer-related molecular mechanisms research
- Reproductive Health and Technologies
- Renal cell carcinoma treatment
- Dendrimers and Hyperbranched Polymers
- Advanced biosensing and bioanalysis techniques
- Chronic Kidney Disease and Diabetes
- Angiogenesis and VEGF in Cancer
- Protease and Inhibitor Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Bladder and Urothelial Cancer Treatments
- Luminescence and Fluorescent Materials
- Dialysis and Renal Disease Management
- Synthesis and Catalytic Reactions
- Evolutionary Psychology and Human Behavior
- Medicinal Plants and Neuroprotection
- Glutathione Transferases and Polymorphisms
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Catalytic C–H Functionalization Methods
Wenzhou Medical University
2014-2024
Wenzhou City People's Hospital
2018-2024
University of California, Berkeley
2022-2023
University at Buffalo, State University of New York
2021
Ministry of Agriculture and Rural Affairs
2019
Huazhong Agricultural University
2019
Overweight and obese females demonstrate a significantly increased risk of anovulatory infertility. This study aims to investigate whether depression score could mediate the association between body shape index (ABSI) infertility, especially in overweight population.
Background Partial nephrectomy (PN) is one of the most preferred nephron-sparing treatments for clinical T1 (cT1) renal cancer, while radiofrequency ablation (RFA) usually used patients who are poor surgical candidates. The long-term oncologic outcome RFA vs. PN cT1 cancer remains undetermined. This meta-analysis aims to compare treatment efficacy and safety with follow-up at least 5 years. Method was performed following PRISMA reporting guidelines. Literature studies that had data on...
Chemoresistance is a significant factor associated with poor outcomes of osteosarcoma patients. The present study aims to identify Chemoresistance-regulated gene signatures and microRNAs (miRNAs) in Gene Expression Omnibus (GEO) database. results Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) included positive regulation transcription, DNA-templated, tryptophan metabolism, the like. Then differentially expressed genes (DEGs) were uploaded Search Tool for Retrieval Interacting (STRING)...
Clear cell renal carcinoma (ccRCC) is a major histological subtype of and can be clinically divided into four stages according to the TNM criteria. Identifying clinical stage-related genes beneficial for improving early diagnosis prognosis ccRCC. By using bioinformatics analysis, we aim identify stage-relevant that are significantly associated with development First, analyzed gene expression microarray data sets: GSE53757 GSE73731. We these five groups by staging information—normal tissue...
Background Aberrant activation of androgen receptor (AR) signaling plays a crucial role in the progression prostate adenocarcinoma (PRAD) and contributes significantly to development enzalutamide resistance. In this study, we aimed identify novel AR-driven signature that can predict prognosis endows potentially reveal therapeutic targets for PRAD. Methods The Seurat package was used preprocess single-cell RNA sequencing (scRNA-seq). Differentially expressed genes were visualized using limma...
ABSTRACT Background The red blood cell distribution width (RDW) and serum albumin levels are potential indicators of inflammatory conditions. However, the relationship between RDW to ratio (RAR) prevalence kidney stones in general adult population is not yet established. Methods This study utilized data from 2007 2018 National Health Nutrition Examination Survey (NHANES) project. RAR were calculated by dividing albumin. Multiple logistic regressions restricted cubic spline (RCS) regression...
Prostate cancer (PCa) endangers the life and health of older men. Most PCa cases develop into castration‑resistant (CRPC) within 2 years. At present, molecular mechanisms occurrence development its transformation to CRPC remain unknown. The present study aimed investigate role CKLF‑like Marvel transmembrane domain containing family member 5 (CMTM5) in mechanism vitro. tissues paired adjacent normal prostate from 70 patients were collected examine expression levels CMTM5 EGFR via...
To further evaluate the influence of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) null genotypes on bladder cancer risk, we conducted a meta-analysis in Chinese population.PubMed databases were electronically searched through April 2016.Nine studies included for our meta-analysis, involving 1646 cases 1938 controls. In general, findings indicated that significant association existed between GSTM1-null genotype risk studied population (odds ratio = 1.56, 95% confidence interval:...
Covalent inhibitors of the papain-like protease (PLpro) from SARS-CoV-2 have great potential as antivirals, but their non-specific reactivity with thiols has limited development. In this report, we performed an 8000 molecule electrophile screen against PLpro and identified α-chloro amide fragment, termed compound 1, which inhibited replication in cells, also had low thiols. Compound 1 covalently reacts active site cysteine PLpro, IC50 18 μM for inhibition. reacted glutathione 1-2 orders...
This article reports the synthesis and characterization of a novel self-immolative linker, based on thiocarbonates, which releases free thiol upon activation via enzymes.
The aza-Diels-Alder reaction of Brassard’s diene 1 with imines represents one the most convenient approaches to chiral α,β-unsaturated δ-lactams, which can be converted into a number biologically important compounds. However, thus far only example on catalytic enantioselective mediated by Brønsted acid was reported (Angew. Chem. Int. Ed. 2006, 45, 4796). In this paper Feng’s group describes protocol employing ytterbium complex N,N′-dioxide ligand 2. A δ-lactams were obtained in moderate...
Abstract Background: Previous observational studies have associated infertility with fundamental physical parameters, including BMI, waist circumference, and excessive weight. Here, we introduced another convincing body shape parameter called A index (ABSI), which can be calculated using weight, height. To explore the association between ABSI in overweight obese females, potential mediating factor association, conducted this cross-sectional study. Methods: 5431 adult female participants from...