A5057022966- Cytomegalovirus and herpesvirus research
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Stock Market Forecasting Methods
- Prostate Cancer Treatment and Research
- Sepsis Diagnosis and Treatment
- Immune Cell Function and Interaction
- Respiratory Support and Mechanisms
- Herpesvirus Infections and Treatments
- Cancer, Hypoxia, and Metabolism
- Cervical Cancer and HPV Research
- Financial Markets and Investment Strategies
- Immunotherapy and Immune Responses
- Endometriosis Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Research Studies
- Chemokine receptors and signaling
- vaccines and immunoinformatics approaches
- interferon and immune responses
- Protease and Inhibitor Mechanisms
- Inflammation biomarkers and pathways
- Blood Coagulation and Thrombosis Mechanisms
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac Structural Anomalies and Repair
Pudong Medical Center
2020-2024
Fudan University
2020-2024
Wenzhou Medical University
2014-2024
Ganzhou People's Hospital
2021-2023
Federation University
2022
Weatherford College
2021
Human Factors (Norway)
2021
Shanghai First Maternity and Infant Hospital
2012-2017
Northeastern University
2015
Ovarian cancer is highly malignant with a gradually increasing incidence and high mortality rate. Immunosuppression induced in ovarian cancer, although the mechanism detail not clear. It has been indicated that HVEM (herpesvirus entry mediator) B- T-lymphocyte attenuator (BTLA) negatively regulates immune responses of T lymphocytes. Here, mRNA was found to be elevated tissue samples primary cells comparison benign samples. We then knocked down expression an cell line, OVCAR3, by...
Background Partial nephrectomy (PN) is one of the most preferred nephron-sparing treatments for clinical T1 (cT1) renal cancer, while radiofrequency ablation (RFA) usually used patients who are poor surgical candidates. The long-term oncologic outcome RFA vs. PN cT1 cancer remains undetermined. This meta-analysis aims to compare treatment efficacy and safety with follow-up at least 5 years. Method was performed following PRISMA reporting guidelines. Literature studies that had data on...
Abstract Acute respiratory distress syndrome (ARDS) is very common in patients with severe acute pancreatitis (SAP), the early interventions are essential to prognosis of SAP patients. We aimed evaluate risk factors for ARDS patients, provide insights into management SAP. treated our hospital from June 1, 2018 May 31, 2020 were included. The characteristics and lab test results collected compared, we conducted logistic regression analyses identify potential A total 281 included finally,...
Epithelial ovarian cancer (EOC) prognosis is associated with International Federation of Gynecology and Obstetrics (FIGO) staging, cell classification, patient age, residual tumor size. However, the molecular markers for predicting EOC remain to be explored. In this study, we investigated expression CD24, COX-2, p53 in EOC, their relationships clinical prognosis. We found that CD24 was detected membrane 90.6 percent (58/64) cases cytoplasm 54.7 (35/64) cases; 78.6 (11/14) borderline tumors...
Our previous studies showed the expression of herpes virus entry mediator (HVEM) is high in ovarian cancer samples and correlated to patient clinic pathological features. As we all know, hypoxic environment main feature tumor. In this work, explored role HVEM cells its effects on HIF-1α, a transcription factor responding hypoxia.The HVEM, HIF-1α apoptosis-related genes was detected by qRT-PCR western blot. The proliferation apoptosis were determined with Cell Counting Kit-8 assay...
Signal transducer and activator of transcription (STAT) is a unique protein family that binds to DNA plays vital role in regulating major physiological cellular processes. Seven STAT genes have been identified the human genome. Several studies suggest members be involved cancer development, progression, metastasis. However, predictive relationship between expression immune cell infiltration endometrial remains unknown.We explored prognosis using various databases. The STRING, GeneMANIA,...
Background. Ferroptosis is a recently described form of intentional cellular damage that iron-dependent and separate from apoptosis, necrosis, autophagy. It has been demonstrated to be adequately regulated by long noncoding RNAs (lncRNAs) in various cancers. However, the predictive profile ferroptosis-related lncRNAs (FRLs) endometrial carcinoma (EC) unknown. Herein, FRLs associated with uterine corpus (UCEC) prognosis were screened predict treatment response EC. Methods. Samples EC adjacent...
N6-methyladenosine (m6A) has been identified as the most common, abundant, and conserved internal transcriptional modification. Long noncoding RNAs (lncRNAs) are consisting of more than 200 nucleotides, expression various lncRNAs may affect cancer prognosis. The impact m6A-associated on uterine corpus endometrial carcinoma (UCEC) prognosis is unknown.In this study, UCEC prognosis-related m6A were screened, bioinformatics analysis was performed, experimental validation conducted. Endometrial...
Background Aberrant activation of androgen receptor (AR) signaling plays a crucial role in the progression prostate adenocarcinoma (PRAD) and contributes significantly to development enzalutamide resistance. In this study, we aimed identify novel AR-driven signature that can predict prognosis endows potentially reveal therapeutic targets for PRAD. Methods The Seurat package was used preprocess single-cell RNA sequencing (scRNA-seq). Differentially expressed genes were visualized using limma...
Prostate cancer (PCa) endangers the life and health of older men. Most PCa cases develop into castration‑resistant (CRPC) within 2 years. At present, molecular mechanisms occurrence development its transformation to CRPC remain unknown. The present study aimed investigate role CKLF‑like Marvel transmembrane domain containing family member 5 (CMTM5) in mechanism vitro. tissues paired adjacent normal prostate from 70 patients were collected examine expression levels CMTM5 EGFR via...
Abstract Background ARHGAP10 is a tumor‐suppressor gene related to ovarian cancer (OC) progression; however, its specific mechanism unclear. Aims To investigate the effect of on OC cell migration, invasion, and glycolysis. Methods Results Quantitative real‐time PCR (qRT‐PCR) quantified mRNA protein expressions AKT, p‐AKT, HK2, SMAD4 were tested by Western blot. EdU, Wound healing, Transwell assay utilized evaluate proliferation, invasion. We used Seahorse XF24 Extracellular Flux Analyzer...
Background This study aimed to investigate the knowledge, attitude, and practice (KAP) of human papillomavirus (HPV) self-sampling among adult women. Methods The cross-sectional, questionnaire-based included women at Shanghai Pudong Hospital from October 14, 2022, March 31, 2023. questionnaire contained demographic information, attitude dimensions. Factors associated with KAP were identified by multivariate logistic regression. Results A total 1843 valid questionnaires collected. average...
Cervical cancer is one of the leading causes cancer‑associated mortality in gynecological diseases and ranks third among female cancers worldwide. Although early detection vaccination have reduced incidence rates, recurrence metastasis lead to high due lack effective medicines. The present study aimed identify novel drug candidates treat cervical cancer. In study, lanatoside C, an FDA‑approved cardiac glycoside used for treatment heart failure, was demonstrated anti‑proliferative cytotoxic...
P16INK4A is a surrogate signature compensating for the specificity and/or sensitivity deficiencies of human papillomavirus (HPV) DNA and Papanicolaou smear (Pap) co-test detecting high-grade cervical squamous intraepithelial lesions or worse (HSIL+). However, traditional p16INK4A immunostaining labour intensive skill demanding, subjective biases cannot be avoided. Herein, we created high-throughput, quantitative diagnostic device, flow cytometry (FCM) assessed its performances in cancer...
We investigated the potential use of galectin-3 (Gal-3) as a prognostic indicator for patients with cardiogenic shock and developed predictive mortality model venoarterial extracorporeal membrane oxygenation (VA-ECMO).We prospectively studied (survivors nonsurvivors) who received VA-ECMO from 2019 to 2021. recorded baseline data, Gal-3, B-type natriuretic peptide (BNP) before ECMO 24-72 h after ECMO. used multivariable logistic regression analyze significant risk factors construct death...
The ratio of regulatory T cells (Treg) in peripheral blood cancer patients has a closely correlation to the occurrence and development ovarian cancer. In this study, our aim explore expression herpesvirus entry mediator (HVEM) its with Tregs. HVEM was detected by ELISA, CD4+ CD25 + Foxp3 positive Tregs flow cytometry. Ovarian cell lines high- low-HVEM were constructed. co-cultured (OC) cells, expressions IL-2 TGF-β1 supernatant western blot used detect STAT5, p-STAT5, Foxp3. results...
The objective is to investigate the relationship between sepsis complicated with heart failure and expression levels of CXC chemokine ligand 8 (CXCL8) endothelin-1 (ET-1).A total 128 patients accepted by Ganzhou People's Hospital from March 2019 December 2021 were collected as observation objects, they separated into a simple group (86 cases) (42 according whether accompanied or not. General data such Sequential Organ Failure Assessment (SOFA) score Acute Physiology Chronic Health Evaluation...
Reports of rare but severe thrombotic events after receiving some COVID-19 vaccines brought concerns for the possibility vaccine-induced coagulation abnormality. However, no study has reported impacts vaccination on function in pregnant women. We aimed to explore whether with inactivated before pregnancy was associated changes conducted a retrospective cohort tertiary-care hospital Shanghai, China. A total 5166 women were included, whom 2721 (52.7%) completed conception. Compared...
Background: The study aimed to detect DEGs associated with BRCA bone metastasis, filter prognosis biomarkers, and explore possible pathways. Methods: GSE175692 dataset was used between metastatic cases non-bone cases, followed by the construction of a PPI network among DEGs. main module then determined pathway analysis on genes within performed. Through performing Cox regression, Kaplan-Meier, nomogram, ROC curve analyses using GSE124647 datasets at same time, most significant prognostic...
Decentralized wastewater increasingly serious, remote control of small scale treatment station operation has become urgent technology problems.This paper mainly introduces the component and function automation system used in decentralized how to use PLC achieve control.The automation, resource optimization, management integration were archived.