A5100361020- Platelet Disorders and Treatments
- Blood groups and transfusion
- Blood properties and coagulation
- Chronic Lymphocytic Leukemia Research
- Pericarditis and Cardiac Tamponade
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Cardiomyopathy and Myosin Studies
- Pelvic floor disorders treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Autoimmune Bullous Skin Diseases
- Cell Adhesion Molecules Research
- Cardiovascular Function and Risk Factors
- Lignin and Wood Chemistry
- Congenital Diaphragmatic Hernia Studies
- Cardiovascular Health and Disease Prevention
- Enzyme-mediated dye degradation
- Immunodeficiency and Autoimmune Disorders
- Service and Product Innovation
- Arsenic contamination and mitigation
- Diabetic Foot Ulcer Assessment and Management
- Nosocomial Infections in ICU
- Glycogen Storage Diseases and Myoclonus
- Gastrointestinal motility and disorders
Synapse (Netherlands)
2019-2025
Tongji Hospital
2006-2024
Huazhong University of Science and Technology
2006-2024
Xinqiao Hospital
2024
Army Medical University
2022-2024
Linyi People's Hospital
2024
Qinghai Provincial Peoples Hospital
2024
Shanxi Academy of Medical Sciences
2023
Daping Hospital
2022
Maastricht University Medical Centre
2019-2020
Abstract Thrombocytopenia at admission predicts mortality in multiple myeloma (MM) and might link to disease progression. Although thrombocytopenia is known be associated with MM, a possible thrombopathy clinically less known. We conducted case–control study comparing platelet responses of MM patients controls via flow cytometry, integrin αIIbβ3 activation P-selectin exposure, bioluminescent assay, ATP release. No difference was found baseline, but upon stimulation, had decreased activation,...
Thrombosis is a major cause of morbidity and mortality worldwide. Platelet activation by exposed collagen through glycoprotein VI (GPVI) formation neutrophil extracellular traps (NETs) are critical pathogenic factors for arterial venous thrombosis. Both events regulated spleen tyrosine kinase (Syk)-mediated signalling events. Asebogenin dihydrochalcone whose pharmacological effects remain largely unknown. This study aims to investigate the antithrombotic asebogenin underlying molecular...
Interaction of von Willebrand factor (VWF) with platelets requires a conformational change that exposes an epitope within the VWF A1 domain, enabling platelet glycoprotein Ibα binding. Quantification this ''active" conformation has been shown to provide pathophysiological insight into conditions characterized by excessive VWF-platelet interaction.We developed immunosorbent assay based on variable heavy chain antibody fragment against domain as capture antibody. Assay performance in terms...
To reduce the risk of relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT), there have been continuing efforts to optimize conditioning regimens. Our study aimed analyze factors associated with relapsed/refractory (R/R), high-risk acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) post-transplant efficacy a new regimen involving decitabine cladribine. Clinical data 125 patients R/R AML, AML MDS who underwent allo-HSCT were collected. In addition, 35...
Moreau score has been used to differentiate chronic lymphocytic leukemia (CLL) from other mature B-cell neoplasms. However, it showed limitations in Asian patients. Therefore, we conducted a new system replacing CD5 and CD23 with CD43 CD180 evaluate its diagnostic value of CLL. 237 untreated samples diagnosed neoplasms were collected randomly divided into an exploratory validation cohort by 2:1 ratio. The expression CD5, CD19, CD20, CD23, CD43, CD79b, CD180, CD200, FMC7, surface...
This study aimed to evaluate the difference in wall shear stress (WSS) (axial, circumferential, and 3D) between high-risk low-risk plaques patients with moderate carotid artery stenosis identify which time points directions play dominant roles determining risk associated plaques. Forty arteries 30 were examined this study. All underwent high-resolution vessel (HRVW) imaging, diffusion-weighted imaging (DWI), 4D flow MRI; HRVW DWI used separate low- plaque. Twenty-four 16 enrolled. An...
Severe aplastic anemia (SAA) is a life-threatening bone marrow failure disease. Allogeneic hematopoietic stem cell transplantation from matched sibling donor (MSD-HSCT) and intensive immunosuppressive therapy (IST) are 2 major comparable treatments for SAA. As the addition of eltrombopag (EPAG) to standard IST has greatly improved survival prognosis SAA, whether MSD-HSCT or IST/EPAG better choice become matter debate. A study was performed involving 99 patients with newly diagnosed acquired...
We report a case of severe thrombocytopenia following pegylated interferon-α 2a (Peg-IFN-α 2a) treatment hepatitis C virus infection and summarize the clinical characteristics 16 cases IFN-α induced its immune-mediated mechanism.Discontinuation early administration immunosuppressants are effective therapy for thrombocytopenia.
IntroductionLight transmission aggregometry (LTA) is the gold standard for diagnosing bleeding disorders. Although LTA laborious, requires large volumes of blood and relatively insensitive to small changes in platelet function, there still no competing alternative approach replace diagnosis disorders.Materials methodsThis study investigates correlation between flow cytometry-based whole activation test (WB-PACT) whether WB-PACT additional value identification In total, 161 patients with...
Chinese Clinical Trial Registry, ChiCTR-TRC-12002570.URL: http://www.chictr.org.cn/showproj.aspx?proj=6981.
Summary Glucocorticoids (GC) are used as the first‐line treatment of immune thrombocytopenia (ITP), but 10–20% patients insensitive to them. Regulatory T cells (Tregs) can maintain tolerance in autoimmune diseases. The present research pooled 55 with newly diagnosed ITP and 44 healthy volunteers from seven hospitals. All received GC were divided into GC‐sensitive GC‐insensitive groups according curative effect after 2 weeks treatment. levels lymphocyte subgroups Tregs recorded. As results...
Postoperative urine retention (POUR) after lumbar interbody fusion surgery may lead to recatheterization and prolonged hospitalization. In this study, a predictive model was constructed validated. The objective provide nomogram for estimating the risk of POUR then reducing incidence.A total 423 cases were included; 65 these developed POUR, an incidence 15.4%. dataset is divided into training set validation according time. 18 candidate variables selected. screened through LASSO regression....
Background: Our previous multicentre case-control study showed that aging, up-regulation of platelet glycogen synthase kinase-3β (GSK-3β), impaired olfactory function, and ApoEε4 genotype were associated with cognitive decline in type 2 diabetes mellitus (T2DM) patients. However, the causal relationship between these biomarkers development T2DM patients remains unclear.Methods: To further investigate this potential relationship, we designed a 6-year follow-up 273 normal our study. Baseline...