A5101791387- Diabetic Foot Ulcer Assessment and Management
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Peripheral Artery Disease Management
- Wound Healing and Treatments
- Diabetes Management and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Cell Adhesion Molecules Research
- RNA modifications and cancer
- Inflammatory Biomarkers in Disease Prognosis
- Diabetes Treatment and Management
- Cardiac Ischemia and Reperfusion
- Chromatin Remodeling and Cancer
- Genetics and Neurodevelopmental Disorders
- Protease and Inhibitor Mechanisms
- Pain Mechanisms and Treatments
- Circadian rhythm and melatonin
- Long-Term Effects of COVID-19
- High Altitude and Hypoxia
- Metabolism and Genetic Disorders
- GDF15 and Related Biomarkers
Tongji University
2024
Central Hospital of Wuhan
2014-2024
Huazhong University of Science and Technology
2014-2024
Shanghai Pulmonary Hospital
2024
Second Affiliated Hospital of Zhejiang University
2023
University of North Carolina at Chapel Hill
2010-2018
Indiana University School of Medicine
2016
Ningxia Medical University
2014
North Carolina State University
2010
UNC Lineberger Comprehensive Cancer Center
2010
BACKGROUND Highly expressed in the gastrointestinal mucosa, huntingtin-associated protein 1 (HAP1) is closely associated with tumor development and prognosis. AIM To investigate clinical utility of HAP1 expression gastric cancer (GC). METHODS We randomly selected 124 GC patients had not undergone preoperative radiotherapy or chemotherapy, they were diagnosed at Central Hospital Wuhan between May 2013 October 2018. Immunohistochemistry was used to detect paraffin-embedded tissues, as well...
Regulation of the attachment actin filaments to cell membrane at membrane-associated dense plaque (MADP) sites could allow smooth muscle cells modulate their cytostructure in response changes external stress. In this study, tyrosine phosphorylation MADP protein paxillin were measured by Western blot during contraction and relaxation tracheal strips. Tyrosine increased three- fourfold with a time course similar force development contractile stimulation acetylcholine (ACh),...
Type 2 diabetes (T2D) is an independent risk factor for Alzheimer's disease (AD). Exendin-4 (Ex-4), a widely used glucagon-like peptide-1 receptor agonist drug in the treatment of T2D, has been demonstrated therapeutic effects on diabetic encephalopathy (DE). Especially, Ex-4 ameliorates tau hyperphosphorylation and cognitive impairment DE. And these crucial alterations are also important bridge between T2D AD. However, its unique mechanism unclear.The db/db mice, high-fat-diet (HFD) /...
Although type 2 diabetes mellitus (T2DM) patients with coronavirus disease 2019 (COVID-19) develop a more severe condition compared to those without diabetes, the mechanisms for this are unknown. Moreover, impact of treatment antihyperglycemic drugs and glucocorticoids is unclear.From 1584 COVID-19 patients, 364 severe/critical clinical outcome were enrolled final analysis, preexisting T2DM but elevated glucose levels excluded. Epidemiological data obtained status evaluation carried out...
Abstract Objective Sleep strongly activates interictal epileptic activity through an unclear mechanism. We investigated how scalp sleep slow waves (SSWs), whose positive and negative half‐waves reflect the fluctuation of neuronal excitability between up down states, respectively, modulate events in focal epilepsy. Methods Simultaneous polysomnography was performed 45 patients with drug‐resistant epilepsy during intracranial electroencephalographic recording. Scalp SSWs spikes ripples (80–250...
Key Clinical Message Maternally inherited diabetes and deafness (MIDD) is often caused by the m.3243A > G mutation in mitochondrial DNA. Unfortunately, characteristics of MIDD, especially long‐term outcomes heteroplasmic changes, have not been well described previously. The purpose this study was to describe clinical genetic features a family with MIDD after 10 years follow‐up.A 33‐year‐old male patient typical including early‐onset diabetes, deafness, low body mass index, admitted our...
This study aimed to investigate the value of combined detection HCY and NRG4 in diagnosis early diabetic kidney disease (DKD) explore association between ratio HCY/NRG4 DKD.A total 140 patients 43 healthy people were prospectively enrolled. The plasma level, level them measured compare their differences analyze correlation with DKD. independent influencing factors DKD screened, nomograph occurrence was constructed.The levels significantly increased, while decreased (p < 0.01). AUCs predicted...
Abstract Objective To investigate the correlation between platelet‐to‐lymphocyte ratio (PLR) and diabetic foot ulcer (DFU) in patients with type 2 diabetes mellitus (T2DM). Method From January 2018 to August 2019, 206 T2DM admitted Central Hospital of Wuhan, China, were enrolled this study, including 104 DFU (DFU group) 102 without (T2DM group). During same period, 90 healthy subjects randomly screened as normal controls (NC The PLR was explored by comparing three groups. Results PLRs groups...
Type 2 diabetes mellitus (T2DM) is a major contributor to peripheral artery disease (PAD), especially in cases that advance critical limb ischemia (CLI). Accumulating evidence indicates miRNAs play an important role the development of PAD and T2DM. Due limited value current diagnostic methods for CLI T2DM patients, we compared miRNA expression profiles Chinese patients with or without find out whether distinctive could serve as potential biomarkers. We statistically identified 7...
Critical limb ischemia (CLI) is the most severe manifestation of peripheral artery disease, which common but rarely diagnosed. Noninvasive biomarkers are urgently required to assist in diagnosis CLI. Accumulating evidence indicates that miRNAs play an important role development various diseases. In this study, microarray profiling revealed 11 with significantly altered expression four T2DM patients CLI compared sex- and age-matched without independent cohorts, qRT-PCR validation confirmed...
Insulin resistance (IR) is one of the risk factors for chronic kidney disease (CKD) and diabetes. The triglyceride-glucose (TyG) index considered a reliable alternative marker IR. We investigated correlation between TyG severity CKD in patients with latent autoimmune diabetes adults (LADA).This cross-sectional study included 288 LADA department endocrinology at our hospital January 2018 2022. was calculated as Ln [TG (mg/dl) × fasting blood glucose (FBG) / 2]. All individuals were divided...
Abstract Critical Limb Ischemia (CLI) is common but uncommonly diagnosed. Improved recognition and early diagnostic markers for CLI are needed. Therefore, the aim of our study was to identify plasma biomarkers in patients with type 2 diabetes mellitus (T2DM). In this study, antibody-coated glass slide arrays were used determine levels 274 human cytokines four matched cases without CLI. Potential confirmed an independent cohort by ELISA. After adjusting confounding risk factors, only level...
To investigate the role of recombinant human interleukin-11 (rhIL-11) on in vivo mobilization CD34(+)/vascular endothelial growth factor receptor (VEGFR) 2(+) mononuclear cells and collateral vessel remodeling a mouse model hindlimb ischemia.We observed that treatment Sv129 mice with continuous infusion 200-μg/kg rhIL-11 per day led to CD34(+)/VEGFR2(+) peaked at 72 hours. pretreated for hours before femoral artery ligation showed 3-fold increase plantar perfusion, leading faster blood flow...
Aim: The aim of this study was to investigate the relationship between CXCL-6 levels in wound exudates and healing diabetic foot ulcers (DFU). Materials & methods: One hundred patients with neuropathic DFU were recruited. Wound exudate measured by enzyme-linked immunosorbent assay. Patients followed for 24 weeks divided into rapidly nonhealing groups. Results: Compared NH group, mean group significantly higher. After adjusting traditional risk factors, still associated healing. Conclusion:...
This study explored the utility of NLR (neutrophil-to-lymphocyte ratio) as a marker to predict Lower Extremity Peripheral Artery Disease (PAD) in Chinese population, well assess its consistency and diagnostic value with digital subtraction angiography.
Objectives . Chronic foot ulceration is a severe complication of diabetes, driving morbidity and mortality. The aim our study was to identify novel biomarkers impaired wound healing in diabetic ulcers. Methods 109 patients with neuropathic ulcers 30 burn victims otherwise healthy participated. Antibody-coated glass slide arrays were used determine the levels 80 human cytokines pooled plasma or exudate rapidly (RH, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Chinese Clinical Trial Registry, ChiCTR-TRC-12002570.URL: http://www.chictr.org.cn/showproj.aspx?proj=6981.