A5100702262- Neuroscience and Neuropharmacology Research
- Orthopaedic implants and arthroplasty
- Titanium Alloys Microstructure and Properties
- Receptor Mechanisms and Signaling
- Bone Tissue Engineering Materials
- Aquatic Ecosystems and Phytoplankton Dynamics
- Neuropeptides and Animal Physiology
- Toxic Organic Pollutants Impact
- Hip disorders and treatments
- Obesity, Physical Activity, Diet
- Angiogenesis and VEGF in Cancer
- Health disparities and outcomes
- Stress Responses and Cortisol
- Pharmacological Effects of Natural Compounds
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Biomedical Research and Pathophysiology
- Inflammasome and immune disorders
- Physical Activity and Health
- Environmental Toxicology and Ecotoxicology
- Sulfur Compounds in Biology
- Tryptophan and brain disorders
- Redox biology and oxidative stress
- Ultrasound in Clinical Applications
- Epigenetics and DNA Methylation
Jiaxing University
2023-2025
Huazhong University of Science and Technology
2014-2023
Central Hospital of Wuhan
2014-2023
European Synchrotron Radiation Facility
2023
The First People's Hospital of Changzhou
2022
Central South University
2018-2020
Central South University of Forestry and Technology
2020
Cambridge University Press
2011
New York University Press
2011
Purpose Pediatric osteoarticular infections (OAIs) are an orthopedic emergency that can lead to severe sequelae if not treated appropriately. Approximately half of the patients with OAIs in clinical practice fail obtain microbiological results even after undergoing aspiration or surgery, which presents a significant challenge practice. The inability identify pathogens incorrect antibiotic usage under-treatment, increasing risk adverse outcomes. This study aims investigate characteristics and...
Abstract Background The relationship between Protein Convertase Subtilisin Kexin Type 9 inhibitor (PCSK9i) and psychiatric adverse events (AEs) remains unclear due to the limitations of clinical trials. In this study, PCSK9i‐related AEs were realistically observed systematically summarized in real world by data mining FDA AE Reporting System (FAERS). Method Total third quarter 2015 first 2023 obtained from FAERS. Psychiatric identified using disproportionality analysis prioritization signals...
Recent studies showed that cyanobacteria-derived microcystin-leucine-arginine (MCLR) can cause hippocampal pathological damage and trigger cognitive impairment; but the underlying mechanisms have not been well understood. The objective of present study was to investigate mechanism MCLR-induced deficit; with a focus on endoplasmic reticulum (ER) stress. Morris water maze test electrophysiological demonstrated MCLR caused spatial memory injury in male Wistar rats; which could be inhibited by...
Chronic stress induces altered energy metabolism and plays important roles in the etiology of depression, which glucocorticoid negative feedback is disrupted due to imbalanced receptor (GR) functions. The mechanism underlying dysregulation GR by chronic remains elusive. In this study, we investigated role AMP-activated protein kinase (AMPK), key enzyme regulating cellular metabolism, related signaling pathways stress-induced dysregulation. cultured rat cortical astrocytes, treatment...
Dangguiliuhuang decoction (DGLHD) is a traditional Chinese medicine formula,which mainly consists of angelica, radix rehmanniae, rehmanniae praeparata, scutellaria baicalensis, coptis chinensis, and golden cypress, used for the treatment diabetes some autoimmune diseases. In this study, we explored potential mechanism DGLHD against insulin resistance fatty liver in vivo vitro. Our data revealed that normalized glucose level, increased expression adiponectin, diminished fat accumulation...
Type 2 diabetes mellitus (T2DM) is a major contributor to peripheral artery disease (PAD), especially in cases that advance critical limb ischemia (CLI). Accumulating evidence indicates miRNAs play an important role the development of PAD and T2DM. Due limited value current diagnostic methods for CLI T2DM patients, we compared miRNA expression profiles Chinese patients with or without find out whether distinctive could serve as potential biomarkers. We statistically identified 7...
Abstract As an endogenous gaseous molecule, hydrogen sulfide (H 2 S) has attracted extensive attention because of its multiple biological effects. However, the effect H S on amygdala‐mediated emotional memory not been elucidated. Here, by employing Pavlovian fear conditioning, animal model widely used to explore neural substrates emotion, we determined whether could regulate memory. It was shown that levels in amygdala rats were significantly elevated after cued conditioning. Both...
Critical limb ischemia (CLI) is the most severe manifestation of peripheral artery disease, which common but rarely diagnosed. Noninvasive biomarkers are urgently required to assist in diagnosis CLI. Accumulating evidence indicates that miRNAs play an important role development various diseases. In this study, microarray profiling revealed 11 with significantly altered expression four T2DM patients CLI compared sex- and age-matched without independent cohorts, qRT-PCR validation confirmed...
Objective: This study aimed to explore whether eukaryotic translation elongation factor 1 alpha 2 affected cell proliferation, migration, and apoptosis via regulating the dimethylation of at lysine 55 in acute myeloid leukemia. Methods: The expressions leukemia lines human normal bone marrow mononuclear cells (as control) were assessed. Control CRISPR-Cas9 lentivirus, knockout vector plasmid, wild type overexpression with a K55R substitution plasmid transfected into AML-193 Kasumi-1 combined...
Circular RNA (circRNA) plays a regulatory role in periodontitis. This study explored whether circ_0138959 affected lipopolysaccharide (LPS)-induced pyroptosis human gingival fibroblasts (HGFs). The periodontal ligament (PDL) tissues and HGFs were derived from patients with periodontitis healthy volunteers. treated LPS considered to mimic vitro. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used evaluate the mRNA expression levels of circRNAs, miR-527, caspase-5...
SUMMARY Age‐related impairments in hippocampus‐dependent spatial learning and memory are not associated with a loss of neurons, but may be related to synaptic changes. In the present study, we analysed behavioural performance adult, middle‐aged old Wistar rats using Morris water maze, as well structure synapses expression autophosphorylated Ca 2+ /calmodulin‐dependent protein kinase II at threonine 286 (pThr286‐αCaMKII), key post‐synaptic CA1 stratum radiatum, same rats. Old showed...
Calcitonin gene-related peptide (CGRP) is a 37 amino acid neuropeptide, which plays critical role in the central nervous system. CGRP binds to G protein-coupled receptors, including CGRP1, couples positively adenylyl cyclase (AC) and protein kinase A (PKA) activation. CGRP1 receptors are enriched nucleus of amygdala (CeA), main part amygdala, regulates conditioned fear memories. Here, we reported importance receptor for synaptic plasticity CeA extinction memory rats. Our electrophysiological...
Neurotoxicity of microcystin-leucine-arginine (MCLR) has been widely reported. However, the mechanism is not fully understood. Using primary hippocampal neurons, we tested hypothesis that MCLR-triggered activation in intracellular free calcium concentration ([Ca 2+ ] i ) induces death neurons. Microcystin-leucine-arginine inhibited cell viability at a range 0.1 to 30 μmol/L and caused dose-dependent increase [Ca . This was observed Ca -free media blocked by an endoplasmic reticulum pump...
Purpose: The purpose of our present study was to, for the first time, identify key genes associated with postpartum depression (PPD) and discovery potential molecular mechanisms this condition. Methods: First, microarray expression profiles GSE45603 dataset were acquired from Gene Expression Omnibus (GEO) in National Center Biotechnology Information (NCBI). weighted gene co-expression network analysis (WGCNA) performed to top three modules differentially expressed (DEGs). Furthermore,...
Abstract By combining the biocompatibility of Ta and excellent performance Nb, β‐type Ta‐xNb ( x = 5, 10, 15 wt %) alloys with three‐dimensional network structure was successfully fabricated. This work designed to carry out systematic study in vitro / vivo highly porous Ta‐Nb alloys. In present study, biological response characterized by cell attachment, cytotoxicity test, gene expression. Cells were well distributed on alloy surface both bulk/porous Ta‐15Nb showd a 0‐1 RGR level. Moreover,...