A5101438807- Gut microbiota and health
- Ginseng Biological Effects and Applications
- Pluripotent Stem Cells Research
- Tracheal and airway disorders
- Berberine and alkaloids research
- Lung Cancer Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Cancer-related Molecular Pathways
- RNA Interference and Gene Delivery
- Reproductive Biology and Fertility
- interferon and immune responses
- Kruppel-like factors research
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Adenosine and Purinergic Signaling
- Calcium signaling and nucleotide metabolism
- Biochemical Acid Research Studies
- Histone Deacetylase Inhibitors Research
- Extracellular vesicles in disease
- Advanced Proteomics Techniques and Applications
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Second People Hospital of Hunan
2023
Hunan University of Traditional Chinese Medicine
2023
Nanjing Chest Hospital
2015-2022
Nanjing Medical University
2020-2022
Nanjing Brain Hospital
2020-2022
Southeast University
2016-2021
Shandong First Medical University
2021
Shandong Provincial QianFoShan Hospital
2021
Chengdu Medical College
2021
The central purpose of this study was to investigate therapeutic effects the botanical derivative, kinsenoside (KD), in experimental autoimmune hepatitis (AIH). Treatment with KD substantially reduced hepatic histopathological damage, induced by lymphocyte infiltration and proinflammatory cytokines, concanavalin A-induced T-cell-mediated hepatitis, dendritic cells (DCs) loaded hepatocellular carcinoma (DC/Hepa1-6) murine AIH. Interactions between immune after treatment AIH were detected...
Berberine (BBR), a small alkaloid, is used as hypoglycemic agent in China. Stachyose (Sta), Rehmannia glutinosa oligosaccharide, acts prebiotic. This study aimed to evaluate whether BBR combined with Sta produced better glycometabolism than alone, and explored the effects on gut microbiota metabolomics. Type-2 diabetic db/db mice were administered (100 mg/kg), (200 or both by gavage once daily. Glucose metabolism, balance of α- β-cells, mucin-2 expression ameliorated treatment Sta, stronger...
The novel Traditional Chinese Medicine Ramulus Mori (Sangzhi) alkaloid tablets (SZ-A) are approved by China National Medical Products Administration for the treatment of type 2 diabetes mellitus (T2DM). However, extensive pharmacological characteristics and underlying mechanism unknown. This study investigated mechanisms which SZ-A ameliorates glucose metabolism in KKAy mice, an animal model T2DM. Diabetic mice were treated intragastrically with once daily 8 weeks, after levels, lipid...
Berberine (BBR) has the beneficial effects of anti-inflammation, anti-bacteria, and anti-diabetes. The clinical application BBR been hindered by its poor gastrointestinal absorption. Stachyose (Sta), a prebiotic agent, improves composition gut microbiota benefits for diabetes. We therefore investigated whether Sta anti-diabetic actions using KKAy mice. Here, we find that combination is more effective than alone in blood glucose control, improvement insulin resistance islet functions,...
Various natural compounds are effective in cancer prevention and treatment with fewer side effects than conventional radiotherapy chemotherapy. Considering the uncertainty of antitumor mechanism Echinacoside (Ech) fact that no study on Ech against non-small cell lung (NSCLC) has been explored previously, this inquired into anti-NSCLC effect its potential mechanisms.The IC50 to NSCLC cells was calculated based a series viability assays. Different concentrations were used treat cells;...
Abstract Objective To investigate whether video-assisted thoracoscopic segmentectomy using near-infrared fluorescence imaging had better intersegmental plane visualization and peri-operative outcome in patients with chronic lung diseases. Methods Data were collected retrospectively from March 2014 August 2019. A total of 92 pulmonary nodules underwent guided uni-port segmentectomy(NIF-VATS), 149 inflation-deflation method(ID-VATS). After 1:1 propensity matching, perioperative outcomes...
Dangguiliuhuang decoction (DGLHD) is a traditional Chinese medicine formula,which mainly consists of angelica, radix rehmanniae, rehmanniae praeparata, scutellaria baicalensis, coptis chinensis, and golden cypress, used for the treatment diabetes some autoimmune diseases. In this study, we explored potential mechanism DGLHD against insulin resistance fatty liver in vivo vitro. Our data revealed that normalized glucose level, increased expression adiponectin, diminished fat accumulation...
Single‑agent histone deacetylase (HDAC) inhibitors have exhibited marked antileukemic activity in preclinical and clinical studies undergone trials combination with standard chemotherapeutics. However, the mechanisms of action therapies are not completely understood. In present study, a novel strategy for treatment acute myeloid leukemia (AML) was identified, which chemotherapeutic agent, homoharringtonine (HHT), combined suberoylanilide hydroxamic acid (SAHA), pan‑HDAC inhibitor. A...
Somatic cell nuclear transfer (SCNT) technology has been applied in the construction of disease model, production transgenic animals, therapeutic cloning, and other fields. However, cloning efficiency remains limited. In our study, to improve SCNT efficiency, brilliant cresyl blue (BCB) staining were chosen select recipient oocytes. addition, DNA methyltransferase inhibitor Zebularine (5 nmol/L) histone deacetylase Scriptaid (0.2 μmol/L) jointly used treat sheep donor cumulus cells...
Aberrant DNA methylation reduces the developmental competence of mammalian somatic cell nuclear transfer (SCNT) embryos. Thus, hypomethylation-associated drugs are beneficial for improving reprogramming efficiency. Therefore, in present study we investigated effect zebularine, a relatively novel methyltransferase inhibitor, on potential ovine SCNT First, reduced overall patterns and gene-specific levels at promoter regions pluripotency genes (octamer-binding transcription factor 4 (Oct4),...
Abstract The cereal formula powder, Zhengda Jingshan (ZDJS), comprises dietary fiber, multivitamins, fine protein, and various ingredients. present study evaluated the effects of ZDJS on glucose metabolism explored corresponding mechanisms in terms modulating gut microbiota fecal metabolome. Type 2 diabetic db/db mice were given (1 g/kg) orally twice daily for 55 days, after which metabolism, inflammation, microbiota, metabolomics assayed. Repeated administration was associated with a trend...
Our study aims to determine the value of bronchial anastomosis using complete continuous suture. Six patients diagnosed with central lung carcinoma who were candidates for right-sided sleeve lobectomy and underwent resection right upper lobe by thoracoscopic surgical procedure. The mean time was 182 min (range, 110 260 min). 49 18 76 bleeding mL 50 mL). Median chest tube drainage 305 200 600 No perioperative deaths or major complications occurred. postoperative bronchoscopy confirmed no...
One of the main causes cancer disease and death worldwide is lung cancer.Our study focused on function KIAA1211 in non-small cell (NSCLC).According to data about NSCLC patients that from Cancer Genome Atlas (TCGA), we found (P=5.06E-06) was significantly higher than adjacent normal.Lentivirus-mediated short hairpin RNA (shRNA) used knockdown BATF expression human A549 line assessed by RT-qPCR Western blot.Cell proliferation evaluated MTT assay Celigo imaging cytometry.Cell apoptosis were...
Abstract Liver diseases are a major health issue in both men and women cause significant mortality worldwide. The hepatoprotective effects of kirenol were evaluated acetaminophen (APAP)‐induced toxicity HepG2 cells ethanol (EtOH)‐ induced hepatotoxicity rats. cytotoxicity (IC 50 , 25 µM/ml) APAP (20 µg/ml) with sylimarin 15 was observed by 3‐(4,5‐dimethylthiazol‐2‐yl)−2,5‐diphenyltetrazolium bromide assay. Furthermore, reactive oxygen species formation, mitochondrial membrane potential,...
Abstract Aim Non‐alcoholic fatty liver is the most common cause of chronic disease. GPR40 a potential therapeutic target for energy metabolic disorders. SZZ15‐11 newly synthesized agonist. In this study, we estimate potency in treatment. Methods vivo, diet‐induced obese (DIO) mice received (50 mg/kg) and TAK875 6 weeks. Blood glucose lipid, hepatocyte lipid morphology were analysed. vitro, HepG2 cells GPR40‐knockdown induced with 0.3 mM oleic acid treated SZZ15‐11. Triglyceride total...
Abstract Background: Berberine (BBR) has the beneficial effects of anti-inflammation, anti-bacteria, and anti-diabetes. The clinical application BBR been hindered by its poor gastrointestinal absorption. Stachyose (Sta), a prebiotic agent, improves composition gut microbiota benefits for diabetes. We therefore investigated whether Sta anti-diabetic actions using type 2 diabetic KKAy mice. Methods: mice were randomly divided into four groups: Con, (200 mg/kg), (100 BBR+Sta (BBR: 100 mg/kg,...