A5100450797- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Lipoproteins and Cardiovascular Health
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Management of metastatic bone disease
- Metabolomics and Mass Spectrometry Studies
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Gastrointestinal Tumor Research and Treatment
- Cancer Treatment and Pharmacology
- Colorectal and Anal Carcinomas
- Spinal Fractures and Fixation Techniques
- Neuroblastoma Research and Treatments
- Antibiotic Resistance in Bacteria
- Cell Adhesion Molecules Research
- Bone Metabolism and Diseases
Chongqing Medical University
2025
Children's Hospital of Chongqing Medical University
2025
iCo Therapeutics (Canada)
2025
Minzu University of China
2025
Xi'an Jiaotong University
2023-2024
Nanjing Medical University
2011-2024
Nanjing Chest Hospital
2014-2024
Jiangsu Province Hospital
2011-2024
Wuhan Children's Hospital
2024
Huazhong University of Science and Technology
2018-2024
Lung adenocarcinoma (LUAD) has been the major cause of tumor-associated mortality in recent years and a poor prognosis. Pyroptosis is regulated via activation inflammasomes participates tumorigenesis. However, effects pyroptosis-related lncRNAs (PRlncRNAs) on LUAD have not yet completely elucidated. Therefore, we attempted to systematically explore patterns cell pyroptosis establish novel signature for predicting survival. Based TCGA database, set up prognostic model by incorporating...
// Xiangming Cao 1,* , Shulin Zhuang 2,* Youfang Hu 3,* Lei Xi 1 Lichun Deng Huaming Sheng and Weisheng Shen Department of Oncology, The Affiliated Jiangyin Hospital Southeast University Medical College, Wuxi, China 2 Pukou District Center for Disease Control Prevention, Nanjing, 3 Children's Health, First Nanjing University, * These authors have contributed equally to this work Correspondence to: Shen, email: Keywords : lncRNA, MEG3, colorectal cancer Received October 14, 2015 Accepted...
We performed this retrospective study to investigate whether the KRAS mutation status and its subtypes could predict effect of first‑line platinum‑based chemotherapy in Chinese patients with non‑small cell lung cancer (NSCLC). Patients received who had mutations were enrolled. Correlations between mutations, specific mutant responses analyzed using Kaplan‑Meier Cox proportional hazard methods. A total 2,183 cases detection included. 218 these indicated have mutations. identified more...
Introduction: Platelet glycoprotein (GP) Ibα is a key receptor for thrombosis. Under high shear conditions, GPIbα-VWF interactions are required initiating platelet adhesion and vessel occlusion. GPIbα also an important checkpoint thrombo-inflammation in acute ischemic stroke. It has been considered as desirable target against stroke decades, but no anti-GPIbα drug successfully developed. Methods: CA1001 was humanized from our unique mAb crossing different species, manufactured under GMP-like...
The N6-methyladenosine binding protein YTHDF1, often upregulated in cancer, promotes tumor growth and hinders immune checkpoint blockade treatment. A comprehensive understanding of the molecular mechanisms governing YTHDF1 stability is pivotal for enhancing clinical response rates effectiveness cancer patients. Here, we report that USP5 interacts with stabilizing it by removing K11-linked polyubiquitination. Insulin activates mTORC1, phosphorylating promoting its dimerization, which binds to...
The authors' previous study demonstrated that the B-cell chronic lymphocytic leukemia/lymphoma (Bcl-2)-like 11 (BCL2L11) (Bim) deletion polymorphism was associated with poor clinical response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in patients non-small cell lung cancer (NSCLC) EGFR mutations. objective of current investigate impact Bim among anaplastic lymphoma (ALK)-positive or ROS proto-oncogene 1, (ROS1)-positive NSCLC who were treated crizotinib.A total 55...
Various natural compounds are effective in cancer prevention and treatment with fewer side effects than conventional radiotherapy chemotherapy. Considering the uncertainty of antitumor mechanism Echinacoside (Ech) fact that no study on Ech against non-small cell lung (NSCLC) has been explored previously, this inquired into anti-NSCLC effect its potential mechanisms.The IC50 to NSCLC cells was calculated based a series viability assays. Different concentrations were used treat cells;...
Data on the clinical activity of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with non-small-cell lung cancer (NSCLC) and uncommon EGFR mutations remain insufficient. This study aimed to investigate effect first-line EGFR-TKIs or platinum-based chemotherapy NSCLC mutations.We retrospectively enrolled 504 EGFR-mutant NSCLC. The characteristics treatment outcomes were collected compared between common NSCLC.Seventy (13.9%) harboring included. Thirty...
The COVID-19 pandemic caused by SARS-CoV-2 virus is an ongoing global health burden. Severe cases of and the rare vaccine-induced-thrombotic-thrombocytopenia (VITT) are both associated with thrombosis thrombocytopenia; however, underlying mechanisms remain inadequately understood. Both infection vaccination utilize spike protein receptor-binding domain (RBD) SARS-CoV-2. We found that intravenous injection recombinant RBD significant platelet clearance in mice. Further investigation revealed...
Abstract Background The prevalence of lung adenocarcinomas (LUADs) has dramatically increased in recent decades. Ferroptosis is a process iron‐dependent regulatory cell death. It still unclear whether the expression ferroptosis‐related genes (FRGs) involved pathogenesis and survival patients with LUAD. Methods We retrieved LUAD data from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases used LASSO Cox regression analysis to select gene signature suitable for modeling. risk...
Atrial structural remodeling is increasingly emphasized in initiation and perpetuation of atrial fibrillation (AF). Osteoprotegerin (OPG)/receptor activator nuclear factor-κB (RANK)/RANK ligand (RANKL) axis, a key regulatory system bone homeostasis, was recently linked to some cardiovascular disorders for its functions myocardial remodeling. It hypothesized that OPG/RANK/RANKL axis involved the development progression AF by regulating remodeling.Clinical data, biopsies right appendage were...
(1) Background: The immune checkpoint blockade (ICB) has shown promising efficacy in non-small-cell lung cancer (NSCLC) patients with significant clinical benefits and durable responses, but the overall response rate to ICBs is only 20%. lack of responsiveness currently a central problem immunotherapy. (2) Methods: Four public cohorts comprising 2986 NSCLC were included study. We screened 158 no benefit (NDB) Rizvi cohort identified NDB-related gene mutations these using univariate...
Circular RNAs (circRNAs) is a novel class of non-coding resulting from the non-canonical splicing linear pre-mRNAs.However, role circRNAs in gastric cancer (GC) remains indistinct.This study aims to explore their potential modulation GC and its prognostic value.We first screen for circRNA expression patterns through adjacent noncancerous tissues by microarray.Based on bioinformatics analysis microarray data, we screened out circRNA, circ-PTPDC1.Then demonstrated that circ-PTPDC1 was...
Circular RNAs (circRNAs) are a class of endogenous non-coding (ncRNAs) with structure covalently closed continuous loops, which can regulate gene expression by acting as microRNA sponge or through other mechanisms. Recent studies have identified that the candidate circRNAs dysregulated in various tumors and hence considered promising diagnostic therapeutic targets across cancer types. However, function lung adenocarcinoma (LUAD) remains unclear. In this article, we investigated LUAD via...
The urgent need for comprehensive and systematic analyses of Shigella as the key pathogen led us to meticulously explore epidemiology molecular attributes isolates. Accordingly, we procured 24 isolates (10 from Xinjiang 14 Wuhan, China) performed serotype identification antimicrobial susceptibility testing. Resistance gene detection homology analysis by polymerase chain reaction pulsed-field gel electrophoresis (PFGE), respectively, were genetic diversity analysis. All identified flexneri,...
Objective: To investigate the expression of osteoprotegerin (OPG)/receptor activator nuclear factor-ĸB (RANK)/RANK ligand (RANKL) axis in stabilization spontaneously restored sinus rhythm (SR) permanent atrial fibrillation (AF) patients after mitral valve (MV) surgery and study its clinical significance. Methods: Clinical data, biopsies right appendages were collected from 135 AF who SR conventional isolated MV replacement. A comparison was made between had recurrence within 7 days with...