A5006613618- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Carbohydrate Chemistry and Synthesis
- Angiogenesis and VEGF in Cancer
- Colorectal Cancer Surgical Treatments
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- Proteoglycans and glycosaminoglycans research
- Cytokine Signaling Pathways and Interactions
- Colorectal and Anal Carcinomas
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Psoriasis: Treatment and Pathogenesis
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Viral-associated cancers and disorders
- Eicosanoids and Hypertension Pharmacology
Shanghai Pulmonary Hospital
2016-2024
Tongji University
2016-2024
Shandong First Medical University
2024
Shandong Provincial Hospital
2024
Nanjing Normal University
2019-2024
Peking University
2018-2024
Peking University Third Hospital
2022-2024
Inner Mongolia University
2023-2024
Shandong Provincial QianFoShan Hospital
2024
Inner Mongolia People's Hospital
2023-2024
Abstract Lung cancer is a highly heterogeneous disease. Cancer cells and within the tumor microenvironment together determine disease progression, as well response to or escape from treatment. To map cell type-specific transcriptome landscape of their in advanced non-small lung (NSCLC), we analyze 42 tissue biopsy samples stage III/IV NSCLC patients by single RNA sequencing present large scale, resolution profiles NSCLCs. In addition types described previous studies early cancer, are able...
Abstract Reactive oxygen species (ROS) are associated with multiple cellular functions such as cell proliferation, differentiation, and apoptosis. However, the direct roles of endogenous ROS production still remain to be elucidated. In this study, we found that high levels were spontaneously produced by ovarian prostate cancer cells. This elevated was inhibited NADPH oxidase inhibitor diphenylene iodonium (DPI) mitochondria electron chain rotenone in To further analyze source production,...
Abstract The lack of response to treatment in most lung cancer patients suggests the value broadening benefit anti–PD-1/PD-L1 monotherapy. Judicious dosing antiangiogenic agents such as apatinib (VEGFR2-TKI) can modulate tumor immunosuppressive microenvironment, which contributes resistance treatment. We therefore hypothesized that inhibiting angiogenesis could enhance therapeutic efficacy PD-1/PD-L1 blockade. Here, using a syngeneic mouse model, we demonstrated low-dose alleviated hypoxia,...
Ganciclovir (GCV) and acyclovir (ACV) are guanine nucleoside analogues that inhibit lytic herpesvirus replication. GCV ACV must be monophosphorylated by virally encoded enzymes to converted into nucleotides incorporated viral DNA. However, whether and/or phosphorylation in Epstein-Barr virus (EBV)-infected cells is mediated primarily the EBV-encoded protein kinase (EBV-PK), thymidine (EBV-TK), or both controversial. To examine this question, we constructed EBV mutants containing stop codons...
Cancer-associated fibroblasts (CAFs), one of the principal constituents tumor microenvironment, have a pivotal role in progression. Dysregulation microRNAs (miRNAs) CAFs contributes to tumor-promoting ability CAFs. However, mechanism underlying involvement miRNAs gastric cancer (GC) is not fully understood. This study aimed explore effects miRNA-214 on GC migration and invasion.The primary corresponding normal (NFs) were isolated. Cell counting kit-8, EdU cell proliferation staining...
Immune checkpoint inhibitors targeting the programmed cell death receptor/ligand 1 (PD‐1/PD‐L1) pathway have profoundly improved clinical management of non‐small‐cell lung cancer (NSCLC). Nevertheless, superiority single‐agent PD‐1/PD‐L1 in pretreated EGFR mutant patients has turned out to be moderate. One proposed mechanism for poor response immune is an immunosuppressive tumor microenvironment. Therefore, we utilized two autochthonous ‐driven models investigate dynamic microenvironmental...
CD73 is one of the critical component in formation immunosuppressive microenvironment cancers. We aimed to provide an overview current status expression and its relationship with clinicopathlogical features prognosis different cancers.PubMed, Web Science, EMBASE Cochrane library were searched identify relevant studies. level distinct cancers characteristics investigated using online database. Meta-analyses conducted RevMan v5.0 STATA v12.0.Fourteen publications 2951 cases included. The...
The androgen receptor (AR) is required for castration-resistant prostate cancer (CRPC) progression, but the function and disease relevance of AR-bound enhancers remain unclear. Here, we identify a group AR-regulated enhancer RNAs (e.g., PSA eRNA) that are upregulated in CRPC cells, patient-derived xenografts (PDXs), patient tissues. eRNA binds to CYCLIN T1, activates P-TEFb, promotes cis trans target gene transcription by increasing serine-2 phosphorylation RNA polymerase II (Pol II-Ser2p)....
KRAS mutation is one of the most common oncogenic drivers in NSCLC, however, response to immunotherapy heterogeneous owing distinct co-occurring genomic alterations. KRAS/LKB1 co-mutated lung adenocarcinoma displays poor PD-1 blockade whereas mechanism remains undetermined.
Insulin-like growth factor-1 (IGF-1) is an angiogenic and oncogenic factor that activates signal transduction pathways involved in the expression of transcriptional regulators tumorigenesis. RUNX2, a member Ig-loop family transcription factors expressed vascular endothelial cells (EC) regulates EC migration, invasion, proliferation. Here we show IGF-1 its receptor regulate post-translational changes RUNX2 to activate DNA binding proliferating EC. The phosphatidylinositol 3-kinase (PI3K)...
Background Immune checkpoint inhibitors (ICIs) brought about a major paradigm shift in non-small cell lung cancer (NSCLC) treatment. However, the use of ICIs is related to an unforeseeable pattern immune-related adverse events (irAEs). Hence, more precise biomarkers are needed predict incidence irAEs prevent overtreatment and decrease occurrences irAEs. This study was designed identify capable clinical features plasma inflammatory factors for predicting Methods A total 67 patients who...
RUNX2 is a member of the runt family DNA-binding transcription factors. mediates endothelial cell migration and invasion during tumor angiogenesis expressed in metastatic breast prostate tumors. Our published studies showed that activity low growth arrest, but elevated proliferating cells. To investigate its role proliferation cycle regulation, was depleted human bone marrow cells using RNA interference. Specific depletion inhibited as measured by electrophoretic mobility shift assay...
Abstract Most cancer lethality is caused by metastasis. To gain insight into the molecular basis of tumor progression to metastasis, we used 21T series human mammary epithelial cells obtained successive biopsies from one breast patient. The c-erbB2 gene amplified and overexpressed in each three lines. erbB receptor tyrosine kinase–activated phosphatidylinositol 3-kinase/Akt signaling cascade crucial for development maintenance cells, dysregulation this pathway frequently associated with...
ABSTRACT The Epstein-Barr virus (EBV) latent-to-lytic switch is mediated by the viral proteins BZLF1 (Z), BRLF1 (R), and BRRF1 (Na). Since we previously showed that DNA-damaging agents (including chemotherapy irradiation) can induce EBV lytic reactivation recently demonstrated wild-type p53 contributes to reactivation, investigated role of ATM kinase during reactivation. phosphorylates activates p53, as well numerous other substrates involved in cellular DNA damage response. Using an...