A5100415774- Flavonoids in Medical Research
- Ginseng Biological Effects and Applications
- PI3K/AKT/mTOR signaling in cancer
- Sesquiterpenes and Asteraceae Studies
- Traditional Chinese Medicine Analysis
- Chronic Lymphocytic Leukemia Research
- Hops Chemistry and Applications
- Ginger and Zingiberaceae research
- Pancreatic and Hepatic Oncology Research
- Natural product bioactivities and synthesis
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Phytochemistry and biological activity of medicinal plants
- Respiratory Support and Mechanisms
- Silymarin and Mushroom Poisoning
- Hematological disorders and diagnostics
- Medicinal Plant Pharmacodynamics Research
- Cancer-related cognitive impairment studies
- Cancer Genomics and Diagnostics
- Hedgehog Signaling Pathway Studies
- Blood groups and transfusion
- Inflammatory Biomarkers in Disease Prognosis
- Mast cells and histamine
- Pharmacogenetics and Drug Metabolism
- Phosphodiesterase function and regulation
First Affiliated Hospital of Henan University
2023-2024
St. Michael's Hospital
2023
First Affiliated Hospital of Guangzhou Medical University
2023
Guangzhou Medical University
2023
Sunnybrook Health Science Centre
2023
University of Toronto
2023
Kyungpook National University
2020-2023
China-Japan Friendship Hospital
2020-2023
State Key Laboratory of Respiratory Disease
2023
Shandong Tumor Hospital
2023
Oral cancer remains the leading cause of death worldwide. Rhein is a natural compound extracted from traditional Chinese herbal medicine rhubarb, which has demonstrated therapeutic effects in various cancers. However, specific rhein on oral are still unclear. This study aimed to investigate potential anticancer activity and underlying mechanisms cells. The antigrowth effect cells was estimated by cell proliferation, soft agar colony formation, migration, invasion assay. cycle apoptosis were...
Abstract Background Colorectal cancer (CRC) is a clinically challenging malignant tumor worldwide. As natural product and sesquiterpene lactone, Costunolide (CTD) has been reported to possess anticancer activities. However, the regulation mechanism precise target of this substance remain undiscovered in CRC. In study, we found that CTD inhibited CRC cell proliferation vitro vivo by targeting AKT. Methods Effects on colon growth were evaluated assays, migration invasion, propidium iodide,...
Objective: To compare the effects of prostacyclin (PGI2) and dobutamine on relationship between oxygen delivery (Do2) uptake (Vo2) in stable septic patients. Design: Prospective study using a crossover design with alternate order medications. Patients: Seventeen patients documented sepsis hemodynamic status normal blood lactate concentrations. Eleven were mechanically ventilated. Eight eventually died. Interventions: Do2 Vo2 calculated before after 20-min infusion 5 ng/kg/min PGI2 followed...
Colorectal cancer (CRC) is one of the leading causes mortality and morbidity in world. Rhein has demonstrated therapeutic effects various models. However, its underlying mechanisms action CRC remain poorly understood. We investigated potential anticancer activity rhein vitro vivo. Cell viability anchorage-independent colony formation assays were performed to examine antigrowth on cells. Wound-healing Transwell conducted assess cell migration invasion capacity. cycle apoptosis by flow...
The COVID-19 pandemic caused by SARS-CoV-2 virus is an ongoing global health burden. Severe cases of and the rare vaccine-induced-thrombotic-thrombocytopenia (VITT) are both associated with thrombosis thrombocytopenia; however, underlying mechanisms remain inadequately understood. Both infection vaccination utilize spike protein receptor-binding domain (RBD) SARS-CoV-2. We found that intravenous injection recombinant RBD significant platelet clearance in mice. Further investigation revealed...
[6]-Gingerol, a compound extracted from ginger, has been studied for its therapeutic potential in various types of cancers. However, effects on oral cancer remain largely unknown. Here, we aimed to investigate the anticancer activity and underlying mechanisms [6]-gingerol cells.We analyzed antigrowth cell lines by proliferation, colony formation, migration, invasion assays. We detected cycle apoptosis with flow cytometry further explored action immunoblotting.[6]-Gingerol significantly...
Oral squamous cell carcinoma (OSCC) is an aggressive cancer with limited treatment options. Parishin A, a natural compound derived from
This focus of our research is to investigate the protective effect Baicalin on apoptosis and mTOR/AKT/GSK-3β pathway in substantia nigra neurons a rat model for Parkinson’s disease, induced by 6-Hydroxydopamine. Thirty healthy female Sprague-Dawley rats were randomly divided into control group, group. The Parkinson was established injecting 6-Hydroxydopamine right group intragastrically administered with (25 mg/kg/day) four weeks. At same time, groups equivalent solvents. We observed turns,...
Colorectal cancer (CRC) has a high morbidity and mortality worldwide. 20 (S)-ginsenoside Rh2 (G-Rh2) is natural compound extracted from ginseng, which exhibits anticancer effects in many types. In this study, we demonstrated the effect underlying molecular mechanism of G-Rh2 CRC cells vitro vivo. Cell proliferation, migration, invasion, apoptosis, cell cycle, western blot assays were performed to evaluate on cells. pull-down assay was used verify interaction between Axl. Transfection...
Oral squamous cell carcinoma (OSCC) is a prevalent oral and maxillofacial cancer with high mortality as OSCC cells readily invade tissues metastasize to cervical lymph nodes.Although imatinib exhibits potential anticancer remarkable clinical activities that therapeutically affect several types, its specific impact on has yet be fully explored.Therefore, this study investigated the effect of underlying mechanisms.The Cell Counting Kit-8 was used determine viability.Then, morphological...
Background: 20(S)-Ginsenoside Rh2 (G-Rh2) has demonstrated therapeutic effects in many types of cancers. We aimed to investigate the potential anticancer activity and underlying mechanisms G-Rh2 oral cancer cells. Materials Methods: The antigrowth effect cells was stimulated by cell proliferation, soft agar colony formation, migration invasion assay. cycle apoptosis were detected flow cytometry. mechanism explored immunoblotting. Results: significantly inhibited growth inducing...
Oral cancer (OC) has been attracted research attention in recent years as result of its high morbidity and mortality. Costunolide (CTD) possesses potential anticancer bioactive abilities that have confirmed several types cancers. However, effects on oral remain unclear. This study investigated the ability underlying mechanisms CTD OC vivo vitro. Cell viability anchorage-independent colony formation assays were performed to examine antigrowth cells; assessments for migration invasion cells...
6-Shogaol (SHO) and 6-gingerol (GIN), naturally derived compounds of ginger (Zingiber officinale Roscoe), have been found to anti-allergic effects on dermatitis-like skin lesions rhinitis. Although SHO GIN demonstrated a potential in various inflammatory diseases, their efficacy mechanism asthma not largely examined. Therefore, the present study anti-asthmatic T-helper (Th) 2 cell-mediated allergic response pathway an ovalbumin (OVA)-induced mouse model. The model was established with...
Background: Oral cancer is one of the most prevalent malignant tumors worldwide. Silibinin has been reported to exert therapeutic effects in various models. However, its mechanism action oral remains unclear. We aimed examine molecular processes underlying silibinin vitro and vivo as well potential anticancer effects. Next, we investigated both outcomes treatment on cancer. Methods: To investigate growth cells, cell proliferation anchorage-independent colony formation tests were conducted...
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and one of leading causes cancer-related deaths worldwide.Imatinib GNF-5 are breakpoint cluster region-Abelson murine leukemia tyrosine kinase inhibitors which have been approved for treatment chronic myeloid various solid tumors.However, effect underlying mechanisms imatinib in HCC remain poorly defined.In this study, we investigated anticancer activity HepG2 human hepatocarcinoma cells.Cell proliferation...
Background The International Myeloma Working Group (IMWG) consensus criteria for response assessment in multiple myeloma (MM) has methodological limitations. Whole‐body diffusion‐weighted imaging (DWI) with apparent diffusion coefficient (ADC) histogram analysis may be complementary to of MM. Purpose To explore the role ADC based on total tumor volume (ttADC) patients newly diagnosed MM (NDMM). Study Type Retrospective. Population Thirty‐six NDMM. Field Strength/Sequence 3.0T/single‐shot DWI...
This study aimed to explore the effect of CYP2C19 polymorphisms on pharmacokinetics lansoprazole administered by single and successive intravenous (iv) infusions in healthy Chinese volunteers. A total 30 subjects, including 20 extensive metabolizers (EMs) 10 poor (PMs) were recruited randomly assigned three groups receiving doses 15, 60 mg. All subjects received a dose during 60-min period, only mg group continued receive same iv for next seven days (twice daily). Plasma concentrations...
<p>PDF file, 61KB, Figure S5. Performance of CHEMO and SAL groups on the test trials at all study-test intervals DNMTS administered baseline. Errors represent each group's daily error/trial score averaged over successive days (Blocks), presented in five blocks two days. (Error bars denote � SEM).</p>
Abstract Purpose: The role of intensity-modulated radiotherapy (IMRT) and novel combination chemotherapy regimens in locally advanced pancreatic cancer (LAPC) remains unclear. In this study, we focused on comparing survival between first-line alone plus IMRT patients with LAPC. Methods: Atotal 70 from Shandong Cancer Hospital Institute were enrolled. primary endpoint was progression-free (PFS). Survival outcomes estimated by the Kaplan-Meier method compared log-rank test, multivariate Cox...
Abstract Background: Rhein is a natural agent isolated from the traditional Chinese medicine rhubarb, which has been used as in China since ancient times. Although rhein was found to have significant anticancer effects different cancer models, effect and underlying mechanisms of action colorectal (CRC) remain unclear. The mTOR/p70S6 kinase (p70S6K) pathway demonstrated an attractive target for developing novel therapeutics. Methods: human CRC cell lines HCT116, HCT15, DLD1 xenograft mice...