A5039881947- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Pluripotent Stem Cells Research
- Microplastics and Plastic Pollution
- RNA Interference and Gene Delivery
- Pancreatic function and diabetes
- RNA Research and Splicing
- Tissue Engineering and Regenerative Medicine
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Veterinary Oncology Research
- Cellular Mechanics and Interactions
- Streptococcal Infections and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Ginseng Biological Effects and Applications
- MicroRNA in disease regulation
- Hedgehog Signaling Pathway Studies
- Insect symbiosis and bacterial influences
- Aquaculture Nutrition and Growth
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Lipid metabolism and disorders
- Connective tissue disorders research
- Vibrio bacteria research studies
- Multiple Myeloma Research and Treatments
Daegu Gyeongbuk Institute of Science and Technology
2016-2025
Zero to Three
2013
Kyungpook National University
2011
National Veterinary Research and Quarantine Service
2011
Abstract Background Colorectal cancer (CRC) is a clinically challenging malignant tumor worldwide. As natural product and sesquiterpene lactone, Costunolide (CTD) has been reported to possess anticancer activities. However, the regulation mechanism precise target of this substance remain undiscovered in CRC. In study, we found that CTD inhibited CRC cell proliferation vitro vivo by targeting AKT. Methods Effects on colon growth were evaluated assays, migration invasion, propidium iodide,...
The effect of glucose-dependent insulinotropic polypeptide (GIP) on cells under oxidative stress induced by glutamate, a neurotransmitter, and the underlying molecular mechanisms were assessed in present study. We found that pre-treatment HT-22 with glutamate dose-dependent manner, intracellular ROS excessively generated, additional cell damage occurred form lipid peroxidation. neurotoxicity caused excessive was to be ferroptosis not apoptosis. Other factors (GPx-4, Nrf2, Nox1 Hspb1)...
Mesenchymal stem cells (MSCs) are promising candidates for regenerative therapy due to their self-renewal capability, multilineage differentiation potential, and immunomodulatory effects. The molecular characteristics of MSCs influenced by location. Recently, epidural fat (EF) EF-derived (EF-MSCs) have garnered attention potential benefits the spinal microenvironment high expression neural SC markers. However, clinical applications limited cell senescence accessibility EF. Although many...
Pre-mRNA processing factor 4 (PRPF4), a core protein of U4/U6 small nuclear ribonucleoproteins (snRNPs), is crucial for maintaining their structure by interacting with PRPF3 and Cyclophilin H. Beyond its role in splicing, PRPF4 has been implicated cell survival, apoptosis, oncogenesis. Although mutations have associated retinitis pigmentosa, glioblastoma (GBM) remains unclear. This study aimed to investigate the function GBM progression potential as therapeutic target. Gene expression...
Colorectal cancer (CRC) is one of the leading causes mortality and morbidity in world. Rhein has demonstrated therapeutic effects various models. However, its underlying mechanisms action CRC remain poorly understood. We investigated potential anticancer activity rhein vitro vivo. Cell viability anchorage-independent colony formation assays were performed to examine antigrowth on cells. Wound-healing Transwell conducted assess cell migration invasion capacity. cycle apoptosis by flow...
Molecular changes during aging have been studied to understand the mechanism of progress. Herein, in microRNA (miRNA) expression whole blood mice were systemically reverse and propose them as non-invasive biomarkers. Through next-generation sequencing analysis, we selected 27 differentially expressed miRNAs aging. The most recognized function involved was liver steatosis, a type non-alcoholic fatty disease (NAFLD). Among miRNAs, six predicted be NAFLD, miR-16-5p, miR-17-5p, miR-21a-5p,...
Abstract Poly(lactide‐ co ‐glycolide) (PLGA) and elastin‐like polypeptide (ELP) have been widely used as a biodegradable scaffold thermoresponsive matrix, respectively. However, little attention has focused on the combinatorial use of these biomaterials for tissue engineering applications. An ELP matrix TGPG[VGRGD(VGVPG) 6 ] 20 WPC (referred to REP) contains multiple Arg‐Gly‐Asp motifs. This study fabricated porous PLGA scaffolds coated with various concentration via thermally induced phase...
The expression of specific transcription factors determines the differentiated features postmitotic neurons. However, mechanism by which molecules determine neuronal cell fate and extent to functions are conserved in evolution not fully understood. In C. elegans, cholinergic peptidergic SMB sensory/inter/motor neurons innervate muscle quadrants head control amplitude sinusoidal movement. Here we show that LIM homeobox protein LIM-4 characteristics lim-4 mutant animals, terminal...
We developed a qPCR assay based on the β-tubulin gene sequence for shrimp microsporidian parasite Enterocytozoon hepatopenaei (EHP). This reacted with hepatopancreas (HP) of EHP-infected shrimps, and highest copy numbers were found in HP feces samples from Southeast Asian countries (106-108 copies mg-1), while Latin America, Artemia, EHP-contaminated water showed lower amounts (101-103 mg-1 or mL-1 water). No false positive was normal genome, live feeds, other parasitic diseases. tool will...
Successful islet transplantation critically depends on the isolation of healthy islets. However, procedure itself contributes to death due destruction intra- and peri-islet extracellular matrices (ECMs) during digestion. We investigated whether an RGD-containing elastin-like polypeptide (REP) could function as a self-assembling matrix replenish ECMs protects islets from cell death. Immediately following isolation, were coated with REP coacervate particles via isothermal adsorption solution...
The ingestion of microplastics by diverse marine organisms induces behavioral disorders, physiological changes, and immune stress responses. negative effects microplastic exposure in penaeid shrimps are still unclear despite the annual increase consumption these food sources humans aquaculture. Therefore, this study aimed to investigate potential gain a deeper understanding its impacts on culturing shrimp. We generated RNA sequencing data from whiteleg shrimp (Penaeus vannamei) artificially...
Colorectal cancer (CRC) has a high morbidity and mortality worldwide. 20 (S)-ginsenoside Rh2 (G-Rh2) is natural compound extracted from ginseng, which exhibits anticancer effects in many types. In this study, we demonstrated the effect underlying molecular mechanism of G-Rh2 CRC cells vitro vivo. Cell proliferation, migration, invasion, apoptosis, cell cycle, western blot assays were performed to evaluate on cells. pull-down assay was used verify interaction between Axl. Transfection...
In previous studies, the increasing clinical importance of nonalcoholic fatty liver disease (NAFLD) has been recognized. However, specific therapeutic strategies or drugs have not discovered. Vitamin C is a water-soluble antioxidant and cofactor in many important biosynthesis pathways. Recently, researchers reported that mega-dose vitamin treatment had positive effects on various diseases. precise relationship between NAFLD completely elucidated. This study designed to discover progression...