A5076011213- Sirtuins and Resveratrol in Medicine
- Alzheimer's disease research and treatments
- Dermatology and Skin Diseases
- Cell Adhesion Molecules Research
- Sesquiterpenes and Asteraceae Studies
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Immune Response and Inflammation
- Ferroptosis and cancer prognosis
- Psoriasis: Treatment and Pathogenesis
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Hops Chemistry and Applications
- Microplastics and Plastic Pollution
- Genetic and Kidney Cyst Diseases
- Cytokine Signaling Pathways and Interactions
- PI3K/AKT/mTOR signaling in cancer
- Drug Transport and Resistance Mechanisms
- Air Quality and Health Impacts
- HIV Research and Treatment
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Ginseng Biological Effects and Applications
- Phytochemistry and biological activity of medicinal plants
- Systemic Lupus Erythematosus Research
Kyungpook National University
2016-2025
Chungbuk National University
2009-2025
Jeonbuk National University
2022
Chonbuk National University Hospital
2022
Daegu Gyeongbuk Institute of Science and Technology
2021
University of Nevada, Reno
2021
Taiwan Livestock Research Institute
2021
Dong-A University
2021
Korea Advanced Institute of Science and Technology
2021
Soonchunhyang University Hospital
2020
Nicotinamide (NAM) plays essential roles in physiology through facilitating NAD + redox homeostasis.Importantly, at high doses, it protects cells under oxidative stresses, and has shown therapeutic effectiveness a variety of disease conditions.In our previous studies, NAM lowered reactive oxygen species (ROS) levels extended cellular life span primary human cells.In the treated cells, /NADH SIRT1 activity increased, while mitochondrial content decreased autophagy activation.The remaining...
Oral cancer remains the leading cause of death worldwide. Rhein is a natural compound extracted from traditional Chinese herbal medicine rhubarb, which has demonstrated therapeutic effects in various cancers. However, specific rhein on oral are still unclear. This study aimed to investigate potential anticancer activity and underlying mechanisms cells. The antigrowth effect cells was estimated by cell proliferation, soft agar colony formation, migration, invasion assay. cycle apoptosis were...
Pre-mRNA processing factor 4 (PRPF4), a core protein of U4/U6 small nuclear ribonucleoproteins (snRNPs), is crucial for maintaining their structure by interacting with PRPF3 and Cyclophilin H. Beyond its role in splicing, PRPF4 has been implicated cell survival, apoptosis, oncogenesis. Although mutations have associated retinitis pigmentosa, glioblastoma (GBM) remains unclear. This study aimed to investigate the function GBM progression potential as therapeutic target. Gene expression...
Sustainable food resources, including cell-cultured meat and edible insect proteins, are emerging as key solutions to meet future protein demands. This study evaluated the effects of black soldier fly larvae hydrolysate (BLH) on primary cells isolated from broiler leg breast muscle tissues, well abdominal fat tissues. Primary each tissue were characterized for their myogenic adipogenic (stromal vascular fraction, SVF) properties. Cells cultured in a basal medium with five percent FBS...
Primary cilia are dynamic sensory organelles orchestrating key signaling pathways, and disruption of primary ciliogenesis is implicated in a spectrum genetic disorders. The peroxisomal bifunctional enzyme HSD17B4 pivotal for β-oxidation acetyl-CoA synthesis, its deficiency profoundly impairs metabolism. While patients with exhibit ciliopathy-like symptoms due to dysfunctional cilia, the molecular connection between ciliopathy remains poorly understood. Here, we demonstrate that alters...
Abstract Background Colorectal cancer (CRC) is a clinically challenging malignant tumor worldwide. As natural product and sesquiterpene lactone, Costunolide (CTD) has been reported to possess anticancer activities. However, the regulation mechanism precise target of this substance remain undiscovered in CRC. In study, we found that CTD inhibited CRC cell proliferation vitro vivo by targeting AKT. Methods Effects on colon growth were evaluated assays, migration invasion, propidium iodide,...
The effect of glucose-dependent insulinotropic polypeptide (GIP) on cells under oxidative stress induced by glutamate, a neurotransmitter, and the underlying molecular mechanisms were assessed in present study. We found that pre-treatment HT-22 with glutamate dose-dependent manner, intracellular ROS excessively generated, additional cell damage occurred form lipid peroxidation. neurotoxicity caused excessive was to be ferroptosis not apoptosis. Other factors (GPx-4, Nrf2, Nox1 Hspb1)...
Inflammatory bowel disease (IBD) is a chronic inflammatory condition that influenced by various factors, including environmental immune responses, and genetic elements. Among the factors influence IBD progression, macrophages play significant role in generating mediators, an increase number of activated contributes to cellular damage, thereby exacerbating overall conditions. HSPA9, member heat shock protein 70 family, plays crucial regulating mitochondrial processes responding oxidative...
During T cell activation, mitochondrial content increases to meet the high energy demand of rapid proliferation. With this increase, level reactive oxygen species (ROS) also and causes apoptotic death activated cells, thereby facilitating homeostasis. Nicotinamide (NAM) has previously been shown enhance mitochondria quality extend replicative life span human fibroblasts. In study, we examined effect NAM on CD8 + activation. treatment attenuated increase ROS in cells by CD3/CD28 antibodies....
Colorectal cancer (CRC) is one of the leading causes mortality and morbidity in world. Rhein has demonstrated therapeutic effects various models. However, its underlying mechanisms action CRC remain poorly understood. We investigated potential anticancer activity rhein vitro vivo. Cell viability anchorage-independent colony formation assays were performed to examine antigrowth on cells. Wound-healing Transwell conducted assess cell migration invasion capacity. cycle apoptosis by flow...
[6]-Gingerol, a compound extracted from ginger, has been studied for its therapeutic potential in various types of cancers. However, effects on oral cancer remain largely unknown. Here, we aimed to investigate the anticancer activity and underlying mechanisms [6]-gingerol cells.We analyzed antigrowth cell lines by proliferation, colony formation, migration, invasion assays. We detected cycle apoptosis with flow cytometry further explored action immunoblotting.[6]-Gingerol significantly...
Glucose-dependent insulinotropic polypeptide (GIP), a 42-aminoacid hormone, exerts multifaceted effects in physiology, most notably metabolism, obesity, and inflammation. Its significance extends to neuroprotection, promoting neuronal proliferation, maintaining physiological homeostasis, inhibiting cell death, all of which play crucial role the context neurodegenerative diseases. Through intricate signaling pathways involving its cognate receptor (GIPR), member G protein-coupled receptors,...
Juxtaposed with another zinc finger protein 1 (Jazf1) is a and known to affect both prostate cancer type 2 diabetes. Jazf1 inhibits testicular nuclear receptor 4 (TR4) activation through protein-protein interaction, which results in weight loss alleviates However, the role of still poorly understood. Hence, we investigated whether expression associated progression. We confirmed upregulation human tissue samples. In addition, using overexpressing cell lines, DU145 LNCaP, found promoted...
Colorectal cancer (CRC) has a high morbidity and mortality worldwide. 20 (S)-ginsenoside Rh2 (G-Rh2) is natural compound extracted from ginseng, which exhibits anticancer effects in many types. In this study, we demonstrated the effect underlying molecular mechanism of G-Rh2 CRC cells vitro vivo. Cell proliferation, migration, invasion, apoptosis, cell cycle, western blot assays were performed to evaluate on cells. pull-down assay was used verify interaction between Axl. Transfection...
The primary cilium, an antenna-like structure on the cell surface, acts as a mechanical and chemical sensory organelle. Primary cilia play critical roles in sensing extracellular environment to coordinate various developmental homeostatic signaling pathways. Here, we showed that depletion of heat shock protein family A member 9 (HSPA9)/mortalin stimulates ciliogenesis SH-SY5Y cells. downregulation HSPA9 enhances mitochondrial stress by increasing fragmentation reactive oxygen species (mtROS)...
Ten-eleven translocation methylcytosine dioxygenase 1 (Teil) initiates DNA demethylation by converting 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) at CpG-rich regions of genes, which have key roles in adult neurogenesis and memory. In addition, the overexpression Tet1 with 5-hmC alteration patients psychosis has also been reported, for instance schizophrenia bipolar disorders. The mechanism underlying brain; however, is still elusive. present study, we found that...
Lin28, which is highly expressed during embryogenesis, has been shown to play an important role in cell growth and embryonic development. Meanwhile, Lin28 represses let-7 miRNA biogenesis block pre-let-7 processing the cytoplasm. The family of miRNAs known repress oncogenesis cycle progression by targeting oncogenic genes signalling pathways. Consequently, acts as oncogene upregulating targets through repression biogenesis. A recent genome-wide association study (GWAS) showed that many...