A5086427279- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Metabolism, Diabetes, and Cancer
- Helicobacter pylori-related gastroenterology studies
- Diet, Metabolism, and Disease
- Berberine and alkaloids research
- Pancreatic function and diabetes
- Medical Research and Treatments
- Cytokine Signaling Pathways and Interactions
- Ginseng Biological Effects and Applications
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Diabetes Treatment and Management
- Drug Transport and Resistance Mechanisms
- Adipose Tissue and Metabolism
- Pharmacological Effects of Natural Compounds
- Hormonal Regulation and Hypertension
- Liver Disease and Transplantation
- Liver physiology and pathology
- Genomics, phytochemicals, and oxidative stress
- Natural Antidiabetic Agents Studies
- Toxin Mechanisms and Immunotoxins
- Organoselenium and organotellurium chemistry
- Inflammation biomarkers and pathways
- Selenium in Biological Systems
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Institute of Biophysics
2024
Chinese Academy of Sciences
2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2024
Zhengzhou University
2022
Henan Provincial People's Hospital
2022
Griffith University
2020
Yantai University
2017-2018
Gut microbiota plays an essential role in the progression of nonalcoholic fatty liver disease (NAFLD), making gut-liver axis a potential therapeutic strategy. Bacteroides genus, enriched gut symbionts, has shown promise treating liver. However, further investigation is needed to identify specific beneficial strains for metabolic disorders NAFLD and elucidate their underlying mechanisms. In this study, we observed positive correlation between abundance thetaiotaomicron (B. theta) alleviation...
The pandemic of SARS-CoV-2 worldwide with successive emerging variants urgently calls for small-molecule oral drugs broad-spectrum antiviral activity. Here, we show that carrimycin, a new macrolide antibiotic in the clinic and an candidate phase III trials, decreases efficiency programmed –1 ribosomal frameshifting coronaviruses thus impedes viral replication fashion. Carrimycin binds directly to coronaviral frameshift-stimulatory element (FSE) RNA pseudoknot, interrupting protein...
Berberine (BBR), a small alkaloid, is used as hypoglycemic agent in China. Stachyose (Sta), Rehmannia glutinosa oligosaccharide, acts prebiotic. This study aimed to evaluate whether BBR combined with Sta produced better glycometabolism than alone, and explored the effects on gut microbiota metabolomics. Type-2 diabetic db/db mice were administered (100 mg/kg), (200 or both by gavage once daily. Glucose metabolism, balance of α- β-cells, mucin-2 expression ameliorated treatment Sta, stronger...
The novel Traditional Chinese Medicine Ramulus Mori (Sangzhi) alkaloid tablets (SZ-A) are approved by China National Medical Products Administration for the treatment of type 2 diabetes mellitus (T2DM). However, extensive pharmacological characteristics and underlying mechanism unknown. This study investigated mechanisms which SZ-A ameliorates glucose metabolism in KKAy mice, an animal model T2DM. Diabetic mice were treated intragastrically with once daily 8 weeks, after levels, lipid...
Although therapies based on direct-acting antivirals (DAAs) effectively eradicate hepatitis C virus (HCV) in patients, there is still a high risk of liver fibrosis even after sustained virological response.Therefore, it great clinical importance to understand the mechanism potential factors that promote cure by treatment with DAAs.Here, we found tubulointerstitial nephritis antigen-like 1 (TINAGL1) significantly increased HCV-infected hepatocytes and patients fibrosis, higher TINAGL1...
Berberine (BBR) has the beneficial effects of anti-inflammation, anti-bacteria, and anti-diabetes. The clinical application BBR been hindered by its poor gastrointestinal absorption. Stachyose (Sta), a prebiotic agent, improves composition gut microbiota benefits for diabetes. We therefore investigated whether Sta anti-diabetic actions using KKAy mice. Here, we find that combination is more effective than alone in blood glucose control, improvement insulin resistance islet functions,...
Helicobacter pylori (H. pylori) has characteristics of family cluster infection; however, its family-based infection status, related factors, and transmission pattern in central China, a high-risk area for H. gastric cancer, have not been evaluated. We investigated healthy households to understand patterns disease prevention.To investigate prevention.Blood samples survey questionnaires were collected from 282 families including 772 individuals. The recruited 10 selected communities the...
3-Hydroxy-3-methyl-glutaryl CoA (HMG-CoA) reductase inhibitors or statins are competitive of the rate-limiting enzyme in cholesterol biosynthesis. Currently, used as first-line therapy treatment diabetic dyslipidemia. However, effects on β cell function remains unclear. This study aims to examine atorvastatin pancreatic obese C57BL/6 J mice and possible mechanisms. Diet-induced obesity (DIO) were treated with (30 mg/kg/day) for 58 days. was assessed by hyperglycemic clamp area...
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic worldwide, and there no specific drug to treat it. Recent results showed that 17-beta-hydroxysteroid dehydrogenase type 13 (HSD17B13) associated with diseases, but these conclusions are controversial. Here, we HSD17B13 was more highly expressed in livers of NAFLD patients, high expression induced murine models cultural hepatocytes treated using various etiologies. The facilitated progression by directly stabilizing...
Berberine is effective for type 2 diabetes mellitus (T2DM), but has limited use in clinic. This study aims to evaluate the effect of berberine combined with stachyose on glycolipid metabolism and gut microbiota explore underlying mechanisms diabetic rats.
Nonalcoholic fatty liver disease (NAFLD), ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), is a worldwide without approved therapeutic drugs. Anti-inflammatory and hepatoprotective drug bicyclol multi-pharmacological active berberine, respectively, have shown beneficial effects on NAFLD in murine nutritional models patients, though the mechanisms remain be illustrated. Here, we investigated combined of berberine mouse induced by Western diet (WD), NASH WD/CCl4. The use...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common metabolic of liver, characterized by hepatic steatosis in more than 5% hepatocytes. However, despite recent approval first drug, resmetirom, for management steatohepatitis, decades target exploration and hundreds clinical trials have failed, highlighting urgent need to find new druggable targets discovery innovative drug candidates against MASLD. Here, we found that glutathione S-transferase alpha 1 (GSTA1)...
The purpose of this study was to explore the effect traditional Chinese medicine Fuyou formula on precocious puberty (PP). Fy may exert an in female rats with PP and GT-7 cells through GPR54/GnRH signaling pathway. To confirm pathway, we first treated GT1-7 observed changes expression related genes proteins GnRH secretion. Then, randomly divided young Sprague-Dawley into control group, model leuprorelin group group. A established by injection danazol postnatal day 5, administered PND15. time...
Hyperglycemia, oxidative stress, and inflammation play key roles in the onset development of diabetic complications such as nephropathy (DN). Diphenyl diselenide (DPDS) is a stable simple organic selenium compound with anti-hyperglycemic, anti-inflammatory, anti-oxidative activities. Nevertheless, vitro, role molecular mechanism DPDS on DN remains unknown. Therefore, we investigated effects tert-butyl hydrogen peroxide (t-BHP)-induced stress lipopolysaccharide (LPS)-induced rat glomerular...
Morus alba L. (Sangzhi) alkaloid (SZ-A) is a new antidiabetic drug approved by the China National Medical Products Administration in 2020. Diabetic nephropathy (DN) common diabetic complication and an important cause of morbidity mortality patients with diabetes. The effects SZ-A on DN remain unknown. This study evaluated Zucker fatty (ZDF) rats explored underlying mechanisms based nitrosative stress, inflammation, fibrosis. ZDF were orally administered 100 200 mg/kg once daily for 9 weeks....
Abstract Based on the multi‐target strategy to treat type 2 diabetes mellitus (T2DM), glucokinase/peroxisome proliferator‐activated receptor γ (GK/PPARγ) dual‐target molecules were constructed by rational combination of pharmacophores from known GK activators and PPARγ agonists. A series agents designed synthesized, their capacities induce transcriptional activity evaluated. Three these compounds showed particularly high potency toward GK, moderate PPARγ, structure–activity relationships...
It is crucial to understand the glucose control within our bodies. Bariatric/metabolic surgeries, including laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (RYGB), provide an avenue for exploring potential key factors involved in maintaining homeostasis since these surgeries have shown promising results improving glycemic among patients with severe type 2 diabetes (T2D). For first time, a markedly altered population of serum proteins after LSG was discovered analyzed...