A5060062592- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Gastrointestinal Tumor Research and Treatment
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Biochemical Analysis and Sensing Techniques
- Liver Disease Diagnosis and Treatment
- Radiology practices and education
- PI3K/AKT/mTOR signaling in cancer
- Cancer Cells and Metastasis
- COVID-19 Clinical Research Studies
- Endoplasmic Reticulum Stress and Disease
- Engineering Education and Curriculum Development
- Single-cell and spatial transcriptomics
- Phytochemistry and Bioactive Compounds
- Protein Tyrosine Phosphatases
- Angiogenesis and VEGF in Cancer
- Helicobacter pylori-related gastroenterology studies
Zhengzhou University
2014-2025
Henan Provincial People's Hospital
2012-2025
Henan University
2019-2024
Zhengzhou People's Hospital
2021
Hefei University of Technology
2016
Huazhong University of Science and Technology
2009
Second Affiliated Hospital of Zhengzhou University
2006
Abstract Azvudine (FNC) is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase (RdRp). Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into Phase III trial for COVID-19 patients. monophosphate inhibited SARS-CoV-2 HCoV-OC43 coronavirus with EC 50 between 1.2 4.3 μM, depending on viruses or cells, selective index (SI) in 15–83 range. Oral administration of rats revealed substantial thymus-homing feature, triphosphate (the active form) concentrated...
Camptothecin (CPT), an effective topoisomerase I inhibitor used in colorectal cancer chemotherapy, often faces limitations due to severe toxicities. Addressing this, we developed OCENM, a nanomedicine featuring the CPT–ET conjugate─comprising cathepsin B-sensitive linker and CPT linked ET peptide targeting leucine-rich alpha-2-glycoprotein 1 (LRG1) encapsulating Olaparib, potent poly ADP-ribose polymerase (PARP) inhibitor. OCENM aims for precise delivery sites overexpressing LRG1, while...
Helicobacter pylori (H. pylori) has characteristics of family cluster infection; however, its family-based infection status, related factors, and transmission pattern in central China, a high-risk area for H. gastric cancer, have not been evaluated. We investigated healthy households to understand patterns disease prevention.To investigate prevention.Blood samples survey questionnaires were collected from 282 families including 772 individuals. The recruited 10 selected communities the...
Background: HOXA10 has been reported to be deregulated in many kinds of cancers including gastric cancer. But its role cancer progression is controversial. Therefore, the current study was performed explore and mechanism Materials methods: IHC Western blotting assays were used assess expression tissues cells. Lentivirus infection alter HOXA10, STAT3 JAK1 NCI-N87 MKN28 MTT, cloning formation, flow cytometry vivo xenotransplantation experiments carried out cell proliferation, apoptosis...
Background Much importance is attached to the clinical application value of circulating tumor cells (CTCs), meanwhile tumor-proximal CTCs detection has interested researchers for its unique advantage. This research mainly discusses correlation portal venous (PoV) counts in different epithelial-mesenchymal transition status with clinicopathologic parameters and postoperative prognosis resectable pancreatic ductal adenocarcinoma patients (PDAC). Methods PDAC (n=60) who received radical...
Circular RNAs (circRNAs) are associated with various diseases, including cancers.However, their roles in colorectal cancer (CRC) have not been established.Hsa_circ_0000847 (circ_SMAD2) is a novel circRNA that was found to be elevated CRC cell lines and tissues.High circ_SMAD2 levels were positively correlated clinicopathological features.Functional assays revealed enhanced invasion, proliferation, tumor growth.Mechanistically, Ribophorin II (RPN2) by inhibiting miR-1258.Therefore, potential...
Abstract Background Gastric cancer is a highly aggressive malignant tumor with heterogeneity and still global health problem. The present study aimed to investigate the role of Cyclin I-like (CCNI2) in regulation phenotype tumorigenesis, as well its underlying mechanisms. Method expression profile CCNI2 gastric was determined based on Cancer Genome Atlas (TCGA) database immunohistochemical staining. effects altered biological phenotypes such proliferation, clone formation, apoptosis...
Gastric cancer (GC) is one of the most prevalent cancers and severely endangers human health. Due to low rate diagnosis, patients with GC are diagnosed as advanced. CDC42 effector protein 3 (CDC42EP3) has been revealed be involved in several types cancers' development progression. However, function CDC42EP3 not yet clear. expression was detected by immunohistochemistry, quantitative real-time PCR Western blot assay tumor tissues cell lines GC. knockdown models were constructed lentivirus...
Bitter melon seed oil (BMSO) was found to have an advantageous effect on anti-obesity. Up date, the mechanisms underlying this process been extensively investigated. However, there are very few reports focusing roles of central nervous system (CNS) involved. In study, Golgi-Cox staining and western blotting assays were used examine hypothalamic spine density expression levels NMDA-2B receptor P-S6 protein, respectively. A significant reduction concerning observed in HFD mice, a phenomenon...
Hemoclips have been used to protect leakage after endoscopic resection of large colorectal polyps or early-staged rectal cancer, for perforation the sigmoid colon during colonoscopy. However, clips were seldom manage anastomotic low anterior cancer. A patient with postoperative cancer was successfully treated by hemoclips under colonoscopic vision failure conservative treatment. Postoperative course uncomplicated and discharged from hospital seven days later. Endoscopic should be considered...
Colorectal cancer is one of the most common cancers with high morbidity and mortality. Effective treatments to improve prognosis are still lacking. The results online analysis tools showed that OCT1 LDHA were highly expressed in colorectal cancer, expression was associated poor prognosis. Immunofluorescence demonstrated co-localized cells. In cells, upregulated by overexpression, but downregulated knockdown. overexpression promoted cell migration. or knockdown inhibited migration,...
Multi-organ metastasis has been the main cause of death in patients with Gastric cancer (GC). The prognosis for metastasized GC is still very poor. Long noncoding RNAs (lncRNAs) always reported to be closely related metastasis.
Angiogenesis serves a role in the growth, metastasis and prognosis of tumors. The aim present study was to evaluate angiogenic ability clinical significance immune biomarker soluble interleukin‑2 receptor (sIL‑2R) gastric cancer (GC) patients. Serum levels sIL‑2R were measured 35 GC patients with different stages disease 32 healthy individuals, it investigated whether associated angiogenesis factors, including vascular endothelial growth factor (VEGF) transforming (TGF)‑β1. Human umbilical...
Objective To study the relationship between protein arginine methyltransferase 7 (PRMT7)expression and hepatocellular carcinoma(HCC)cell line metastatic potential epithelial-mesenchymal transition(EMT). Methods Reverse transcriptase-polymerase chain reaction (RT-PCR) Western blotting were applied to detect PRMT7 expression of HCC lines L02, Hep3B, Huh7, MHCC97H, LM3.Markers EMT, matrix metalloproteinase(MMP)-2, MMP-9 invasion migration capacity studied after inhibiting or...
Objective To study the mechanisms of ADAM17/TACE regulating proliferation and apoptosis pancreatic ductal adenocarcinoma cells.Methods The expression in 58 cases tissues 6 cancer cell lines were detected by using immunohistochemistry FACS.After small interfering RNA (siRNA) to block ADAM17/TACE,cell analyzed CCK-8 Kit poly(ADP-ribose)polymerase (PARP) Western blotting.After inhibiting epidermal growth factor receptor (EGFR) AKT passway,the levels EGFR/p-EGFR,AKT/p-AKT blotting.Results...