A5100651082- Metabolomics and Mass Spectrometry Studies
- Plant Molecular Biology Research
- Identification and Quantification in Food
- Plant biochemistry and biosynthesis
- Plant Stress Responses and Tolerance
- MicroRNA in disease regulation
- Medicinal Plant Pharmacodynamics Research
- Plant Gene Expression Analysis
- Photosynthetic Processes and Mechanisms
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Insect-Plant Interactions and Control
- Light effects on plants
- Anesthesia and Neurotoxicity Research
- Neurological Disease Mechanisms and Treatments
- Plant Virus Research Studies
- Genomics and Phylogenetic Studies
- Genetic Mapping and Diversity in Plants and Animals
- Circular RNAs in diseases
- Autoimmune Neurological Disorders and Treatments
- Extracellular vesicles in disease
- Traditional and Medicinal Uses of Annonaceae
- Plant Pathogenic Bacteria Studies
- Cancer Mechanisms and Therapy
Wenzhou Medical University
2019-2025
Zhengzhou University
2021-2024
Henan Provincial People's Hospital
2021-2024
Henan University
2021-2024
Shanxi Medical University
2023
Adrian College
2023
Directorate of Medicinal and Aromatic Plants Research
2023
Second Hospital of Shanxi Medical University
2023
Zhejiang University of Technology
2023
Hunan Academy of Agricultural Sciences
2017-2022
Intestinal epithelial barrier dysfunction with dysbiosis of gut microbiota contributes to the occurrence and acceleration colitis.
Pepper (Capsicum annuum L.) fruit development is a complex and genetically programmed process. In this study, we conducted integrative analysis of transcriptome proteome profiles during pepper development. A total 23 349 transcripts 5455 protein groups were identified in four developmental stages two varieties. The numbers proteins decreased gradually across development, the most significant changes transcript levels happened from mature green (MG) to breaker (Br) stages. Poor correlation...
Circular RNA (circRNA) hsa_circ_0008450 has been shown to be up-regulated in hepatocellular carcinoma (HCC). However, the functional role of and its molecular mechanism are still unknown.We used qRT-PCR Western blot examine expression levels hsa_circ_0008450, microRNA-214-3p (miR-214-3p), enhancer zeste homolog 2 (EZH2) protein. CCK8 assay wound healing were detect cell viability migration capability. Cell apoptosis was assessed by flow cytometry. Luciferase reporter explore interaction...
The inbred “SJ11-3” pepper was cultured in yellow brown soil, paddy fluvo-aquic and pastoral the factors affecting absorption of trace elements fruit quality were analyzed. results showed that physicochemical properties soils significantly different, which led to differences nutritional fruits. pH value had a significant effect on pepper. increase promoted magnesium molybdenum but inhibited zinc, copper, manganese, iron. stepwise multivariable regression analysis amount soil main factor...
This study aimed to evaluate the long-term health outcomes and quality of life (HRQoL) associated with untreated pelvic floor dysfunction (PFD) in women, identify key factors contributing symptom severity. A cohort 1,651 women aged 18 years older PFD were recruited between June 2018 August 2023. Data on sociodemographic, lifestyle factors, clinical history collected via questionnaires assessments. The Pelvic Floor Distress Inventory (PFDI-20) Short Form-12 (SF-12) used assess severity HRQoL....
Signal transducer and activator of transcription 3 (STAT3), a transcriptional factor involved in tumorigenesis cancer stemness formation, contributes to drug resistance therapies. STAT3 not only mediates gene but also participates microRNA suppression. This study identified STAT3-downstream micro RNA (miRNA) against regorafenib colorectal stem-like tumorspheres. Small RNAseq was used investigate differential microRNAs cell-derived tumorspheres STAT3-knockdown strain. The miRNA-mediated genes...
Leaf color is directly related to altered photosynthesis. Hence, leaf yellowing mutants can be widely used for the researching plant physiology and functional genomes, cultivating new varieties of popular horticultural plants, identifying hybrid purity (as markers). Here, we constructed a 60 Co-γ F 2 population from -yellowing mutant R24 via radiation mutation with inbred line WT21 pepper. Genetic analysis showed that leaf-yellowing was controlled by single recessive gene. By applying Bulk...
The male-sterile line has been largely used in the hybrid seed production of pepper, which can effectively improve efficiency production. However, formation mechanism male sterility pepper remains unclear. In present study, we compared gene expression patterns between cytoplasmic sterile 9704A and its maintainer 9704B during floral bud development using RNA sequencing technology. A total 547 976 2 416 Differentially Expressed Genes (DEGs) were identified stage S1, S2 S3, respectively, more...
As one of the most important vegetable crops, pepper has rich nutritional value and high economic value. Increasing heat stress due to global warming a negative impact on growth yield pepper.To understand response mechanism pepper, an iTRAQ-based quantitative proteomic analysis was employed identify possible heat-responsive proteins metabolic pathways in 17CL30 05S180 seedlings under stress.In present study, we investigated changes phenotype, physiology, proteome heat-tolerant (17CL30)...
An asymmetric [3+2] cycloaddition of quinone esters with 2,3-dihydrofuran has been realized via a newly developed Cu(II)/SPDO complex. It provides straightforward access to 2,3,3a,8a-tetrahydrofuro[2,3-b]benzofurans (TFB) high enantioselectivity (up 97.5:2.5 er) and diastereoselectivity (all >20:1 dr). The resulting adducts contain two adjacent stereocenters continuously functionalized benzene ring. Additionally, this transformation could be easily performed on gram scale, allowing for...
Capsicum annuum is also known as chili which one of the most important vegetable crops grown in world. Breeding new varieties with heterosis could improve quality pepper, increase yield, growth potential, disease resistance, adaptability, and seed viability. To investigate among three cross combinations different parents, mRNA-miRNA integrated analysis was performed. A total number 22,659,009 to 36,423,818 clean data were generated from mRNA-seq 81 libraries, unique mapped reads 35,495,567...
Limited knowledge is available for phosphorylation modifications in pepper (Capsicum annuum L.), especially fruit development. In this study, we conducted the first comprehensive phosphoproteomic analysis of at four development stage by Tandem Mass Tag proteomic approaches. A total 2639 unique phosphopeptides spanning 1566 proteins with 4150 nonredundant sites were identified, among which 2327 peptides 1413 accurately quantified different stages. Mature Green (MG) to breaker showed largest...
Abstract Purpose: The aim of the present study was to screen differential metabolites gastric cancer (GC) and identify key metabolic pathways GC. Methods: GC (n=28) matched paracancerous (PC) tissues were collected, LC-MS/MS analysis performed detect PC tissues. Metabolite based on enriched by MetaboAnalyst, genes related metabolite identified using KEGGREST function R software package. Transcriptomics data from Cancer Genome Atlas (TCGA) analyzed obtain differentially expressed (DEGs)...
Leaderless translation is prevalent in haloarchaea, with many of these leaderless transcripts possessing short 5'-untranslated regions (UTRs) less than 10 nucleotides. Whereas, little known about the function this very 5'-UTR. Our previous studies determined that just four nucleotides preceded start codon hsp70 mRNA Natrinema sp. J7, residues -3A and +4G, relative to A ATG codon, acting as preferred bases around all haloarchaeal genes. Here, we examined effects flanking on gene expression....
Abstract Background Gastric cancer is a highly aggressive malignant tumor with heterogeneity and still global health problem. The present study aimed to investigate the role of Cyclin I-like (CCNI2) in regulation phenotype tumorigenesis, as well its underlying mechanisms. Method expression profile CCNI2 gastric was determined based on Cancer Genome Atlas (TCGA) database immunohistochemical staining. effects altered biological phenotypes such proliferation, clone formation, apoptosis...
Purpose: Prognostic prediction after curative resection of primary hepatocellular carcinoma (PHCC) remains an arduous task. The S-index calculated from γ-glutamyl transpeptidase, albumin, and platelets is reported to predict the severity liver fibrosis. We constructed a nomogram for predicting survival probability PHCC based on new indicator, S-index, combined with other routine clinical parameters. Patients methods: selected 490 patients postradical surgery at First Affiliated Hospital...
Light is vital for plant growth and development, the germination of many seeds development seedlings are very sensitive to light environment. Under no or low conditions, pepper will accelerate elongation hypocotyl obtain light. To elucidate molecular mechanism by which regulates in pepper, RNA sequencing was performed analyze hypocotyls cotyledons yellowing mutant R24 under three different intensity treatments. A total 35,341 gene were identified; moreover, during treatment, 9695 new genes...