A5061357773- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Neurological Disease Mechanisms and Treatments
- Natural product bioactivities and synthesis
- Flavonoids in Medical Research
- Bioactive natural compounds
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- SARS-CoV-2 and COVID-19 Research
- Orthopaedic implants and arthroplasty
- Immune Cell Function and Interaction
- Endoplasmic Reticulum Stress and Disease
- Metabolomics and Mass Spectrometry Studies
- Complement system in diseases
- Lipid metabolism and biosynthesis
- RNA Research and Splicing
- Saffron Plant Research Studies
- Drug Transport and Resistance Mechanisms
- COVID-19 Clinical Research Studies
- Plant-based Medicinal Research
- Analytical Chemistry and Chromatography
- Ferroptosis and cancer prognosis
- Orthopedic Infections and Treatments
- Medicinal Plant Pharmacodynamics Research
- Advancements in Transdermal Drug Delivery
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Sichuan University
2024-2025
Zaozhuang Municipal Hospital
2020-2024
Beijing University of Chinese Medicine
2020-2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2020
Jiangsu Normal University
2018-2019
Hebei Medical University
2012-2015
Third Hospital of Hebei Medical University
2014
Abstract Azvudine (FNC) is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase (RdRp). Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into Phase III trial for COVID-19 patients. monophosphate inhibited SARS-CoV-2 HCoV-OC43 coronavirus with EC 50 between 1.2 4.3 μM, depending on viruses or cells, selective index (SI) in 15–83 range. Oral administration of rats revealed substantial thymus-homing feature, triphosphate (the active form) concentrated...
A novel cDNA has been identified from human heart that encodes an unusual mosaic serine protease, designated corin. Corin a predicted structure of type II transmembrane protein and contains two frizzled-like cysteine-rich motifs, seven low density lipoprotein receptor repeats, macrophage scavenger receptor-like domain, trypsin-like protease domain in the extracellular region. Northern analysis showed corin mRNA was highly expressed heart. In mice, detected by situ hybridization cardiac...
Mitochondrial bioenergetic deficits and their resulting glucose hypometabolism are the key pathophysiological modulators that promote neurodegeneration. However, there no specific potential molecules have been identified to treat neurological diseases by regulating energy metabolism repairing mitochondrial damage. Pyruvate dehydrogenase (PDH) complex (PDC), which can be phosphorylated pyruvate kinase (PDK), is gate-keeping enzyme for oxidation. In this study, a small-molecule scutellarin...
Thymus is the important immune organ, responsible for T cell development and differentiation. The lower circulating counts have been observed in patients who died from COVID-19 compared with survivors. Azvudine, also known as FNC, a thymus-homing anti-SARS-CoV-2 drug treating patients. In this study, single-cell transcriptome, proteomics, parallel reaction monitoring (PRM) were applied to insight into activation process of FNC rat SARS-CoV-2 rhesus monkey thymus. results indicated that...
Human cells generate a bulk of aldehydes during lipid peroxidation (LPO), influencing critical cellular processes, such as oxidative stress, protein modification, and DNA damage. Enals, highly reactive α,β-unsaturated aldehydic metabolites, are implicated in various human pathologies, especially neurodegenerative disorders, cancer, cardiovascular diseases. Despite their importance, endogenous enals remain poorly characterized, primarily due to instability low abundance. Herein, we introduced...
In an effort to identify novel therapeutic targets for autoimmunity and transplant rejection, we developed performed a large-scale retroviral-based functional screen select proteins that inhibit antigen receptor-mediated activation of lymphocytes. addition known regulators receptor signaling, identified adaptor protein, SLAP-2 which shares 36% sequence similarity with the Src-like SLAP. Similar SLAP, is predominantly expressed in hematopoietic cells. Overexpression B T cell lines...
Abstract Glutamate‐ammonia ligase (GLUL), which is also called GS (glutamine synthetase), the enzyme that catalyzes synthesis of glutamine from glutamate and ammonia in an ATP‐dependent reaction. Here, we found higher expression GLUL ovarian cancer patients was associated with worse disease‐free survival (DFS) overall (OS). In addition, heterogeneously expressed various cells. The mRNA protein levels NIH:OVCAR‐3 ES‐2 cells were obviously than other types Knockdown or could significantly...
Abstract The discovery of cysteine‐rich secretory protein 3 (CRISP3) has been made in human neutrophils for the first time. Cloning complementary DNA (cDNA) CRISP3 was performed from a cDNA library bone marrow. In patients with mammary carcinoma, we found that lower expression connected to significantly improved DFS (disease‐free survival) and OS (overall survival). Furthermore, level associated negative ANXA1 level. addition, heterogeneous had exhibited diverse carcinoma cells. A...
ABSTRACT Introduction Alzheimer's disease (AD) is a neurodegenerative characterized by Amyloid plaques and neurofibrillary tangles. We explored the potential mechanism which Danggui Shaoyao San (DSS) modulates central glucose metabolism via insulin receptor substrate 1 (IRS1)/glycogen synthase kinase‐3β (GSK3β)/Wnt3a‐β‐catenin pathway, thereby exerting protective effects on cognitive functions. Methods In vitro, HT22 cells were induced with streptozotocin (STZ) to investigate impact of GSK3β...
Abstract Ectodermal‐neural cortex 1 (ENC1) belongs to a member of the kelch family genes. It is an actin‐binding protein and plays pivotal role in neuronal adipocyte differentiation. Here, we found that lower expression ENC1 ovarian cancer patients was associated with favorable prognosis. In addition, heterogeneously expressed various cells. The messenger RNA levels HO‐8910PM NIH:OVCAR‐3 cells were obviously higher than other types Knockdown or could significantly increase reactive oxygen...
There is an urgent need to elucidate the pathogenesis of myocardial ischemia (MI) and potential drug treatments. Here, anti-MI mechanism material basis Ginkgo biloba L. extract (GBE) were studied from perspective energy metabolism flux regulation. Metabolic analysis (MFA) was performed investigate disorder regulatory nodes GBE components in isoproterenol (ISO)-induced ischemia-like cardiomyocytes. It showed that [U-13C] glucose derived m+2 isotopologues upstream tricarboxylic acid (TCA)...