A5101513401- Climate Change and Health Impacts
- Traditional Chinese Medicine Analysis
- Functional Brain Connectivity Studies
- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- Health, Environment, Cognitive Aging
- Plant-based Medicinal Research
- Electroconvulsive Therapy Studies
- Global Health Care Issues
- Air Quality and Health Impacts
- Neural dynamics and brain function
- Flavonoids in Medical Research
- Neurological Disease Mechanisms and Treatments
- Mental Health Research Topics
- Chromatography in Natural Products
- High-Energy Particle Collisions Research
- Sphingolipid Metabolism and Signaling
- Metabolomics and Mass Spectrometry Studies
- Environmental Chemistry and Analysis
- Natural Compounds in Disease Treatment
- Drug Transport and Resistance Mechanisms
- Plant-derived Lignans Synthesis and Bioactivity
- Topic Modeling
- Environmental Quality and Pollution
- Topological Materials and Phenomena
First Affiliated Hospital of Anhui Medical University
2024-2025
Anhui Medical University
2024-2025
National Center for Women and Children’s Health, China CDC
2024
Jiangsu Provincial Center for Disease Control and Prevention
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2023
National Center for Clinical Laboratories
2022
Tianjin Medical University Eye Hospital
2020
Tianjin Medical University
2020
Zhejiang Ocean University
2014-2019
Zhejiang University
2009-2019
Mitochondrial bioenergetic deficits and their resulting glucose hypometabolism are the key pathophysiological modulators that promote neurodegeneration. However, there no specific potential molecules have been identified to treat neurological diseases by regulating energy metabolism repairing mitochondrial damage. Pyruvate dehydrogenase (PDH) complex (PDC), which can be phosphorylated pyruvate kinase (PDK), is gate-keeping enzyme for oxidation. In this study, a small-molecule scutellarin...
N-Nitrosamines, probable human carcinogens, are a group of disinfection byproducts under consideration for drinking water regulation. Currently, no method can determine trace levels alkyl and tobacco-specific nitrosamines (TSNAs) varying physical chemical properties in by single analysis. To tackle this difficulty, we developed solid-phase extraction (SPE) with high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) the determination 14 health concern widely differing...
Abstract Electroconvulsive therapy (ECT) is an effective and rapid neuromodulatory intervention for treatment-resistant major depressive disorders (MDD). However, the precise mechanisms underlying their efficacies remain unclear. Resting-state functional magnetic resonance imaging (fMRI) data were collected from 84 individuals with MDD healthy controls before after ECT, coefficient of variation BOLD signal (CVBOLD) analysis was combined region interest (ROI) connectivity (FC) analysis. To...
The variability in electroconvulsive therapy (ECT) efficacy for depression has received significant attention, particularly regarding the influence of age on treatment outcomes. However, studies examining trajectory ECT across different groups remain limited. This longitudinal study analyzed 1056 intensive data measurements from 132 hospitalized patients diagnosed with major depressive episodes, categorized into a young group (<30 years, n = 69) and an older (≥30 63). Depression severity was...
Abstract Triptolide (TP), the major active component in Tripterygium wilfordii Hook. f., is widely used for treatment of rheumatoid arthritis and autoimmune diseases. However, organ toxicity, especially hepatotoxicity nephrotoxicity, limits its clinical application. To fully understand mechanism underlying TP iTRAQ‐based 2D‐LC‐MS/MS proteomics to detect differentially expressed proteins livers kidneys mice administered LD50 dose TP. Functional annotation revealed that multiple pathways are...
To understand the loss to follow-up of children born pregnant women with HIV infection (HIV-exposed children) and analyze its influencing factors in China 2019.
Vogt-Koyanagi-Harada syndrome is common autoimmune uveitis that can cause blindness. Recent studies have shown plasma exosomes carry disease-related proteins may serve as biomarkers. Here, we aimed to find candidate biomarkers of disease using proteomic analysis exosomes.Exosomes were isolated from the normal controls and Vogt- Koyanagi-Harada patients in following groups: a) initial inflammatory attack (active stage), b) remission after one month treatment (unstable c) stationary phase...
Abstract Biqi capsule is a well‐known traditional Chinese medicine formula that has been widely applied for the clinical treatment of such diseases as rheumatoid arthritis, scapulohumeral periarthritis and cervical spondylopathy. However, there concern regarding toxicity owing to its active ingredients, strychnine brucine. To investigate toxicokinetics brucine after oral administration rats, sensitive simple rapid‐resolution liquid chromatography/tandem mass spectrometry method was developed...
Radiative transfer plays a fundamental role in several disciplines of sciences and engineering. For certain applications turbid media, such as atmosphere or ocean, due to the polarization effect light, vector radiative equation (VRTE) rather than scalar must be adopted. Although there have been numerous discussions on application numerical simulations VRTE, rigorous theoretical analysis is still needed. This letter provides well-posedness VRTE. Under some assumption combined size...