OCT1 regulates the migration of colorectal cancer cells by acting on LDHA.

• DOI: 10.14670/hh-18-613
• Publication Date: 2024-01-01
• Authors: Lihua Li; Wenchao Chen; Gang Wu; Peichun Sun

Colorectal cancer is one of the most common cancers with high morbidity and mortality. Effective treatments to improve prognosis are still lacking. The results online analysis tools showed that OCT1 LDHA were highly expressed in colorectal cancer, expression was associated poor prognosis. Immunofluorescence demonstrated co-localized cells. In cells, upregulated by overexpression, but downregulated knockdown. overexpression promoted cell migration. or knockdown inhibited migration, downregulation restored promoting effect overexpression. upregulation increased levels HK2, GLUT1 proteins Consequently, migration cells upregulating LDHA.