A5052328316- Helicobacter pylori-related gastroenterology studies
- Natural product bioactivities and synthesis
- Flavonoids in Medical Research
- Eosinophilic Esophagitis
- Gastric Cancer Management and Outcomes
- Galectins and Cancer Biology
- Chromatography in Natural Products
- Retinoids in leukemia and cellular processes
- Cancer-related molecular mechanisms research
- Gastroesophageal reflux and treatments
- Cancer, Lipids, and Metabolism
- Pharmacological Effects of Natural Compounds
- Veterinary medicine and infectious diseases
- Mycobacterium research and diagnosis
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
- RNA modifications and cancer
- Gastrointestinal disorders and treatments
- Inflammatory mediators and NSAID effects
- Angiogenesis and VEGF in Cancer
- Cytokine Signaling Pathways and Interactions
- Heavy Metal Exposure and Toxicity
- Chromium effects and bioremediation
- Circular RNAs in diseases
- Genomics, phytochemicals, and oxidative stress
Henan Provincial People's Hospital
2013-2025
Zhengzhou University
2016-2025
Henan University
2020-2024
People’s University
2021
The Graduate Center, CUNY
2011-2013
University of Kentucky
2011-2013
Army Medical University
2011
Markey Cancer Center
2011
University of Virginia Health System
2008-2010
Hokkaido University
2010
Angiogenesis is a crucial step in the growth and metastasis of cancers, since it enables growing tumor to receive oxygen nutrients. Cancer prevention using natural products has become an integral part cancer control. We studied antiangiogenic activity quercetin ex vivo, vivo vitro models. Rat aortic ring assay showed that at non-toxic concentrations significantly inhibited microvessel sprouting exhibited significant inhibition proliferation, migration, invasion tube formation endothelial...
Helicobacter pylori infection is mostly a family-based infectious disease. To facilitate its prevention and management, national consensus meeting was held to review current evidence propose strategies for population-wide H. control management reduce the related disease burden.Fifty-seven experts from 41 major universities institutions in 20 provinces/regions of mainland China were invited modify statements using Delphi process grading recommendations assessment, development evaluation...
Background and aims Current practice on Helicobacter pylori infection mostly focuses individual-based care in the community, but family-based H. management has recently been suggested as a better strategy for control. However, status, risk factors transmission pattern remain to be elucidated. Methods From September 2021 December 2021, 10 735 families (31 098 individuals) were enrolled from 29 of 31 provinces mainland China examine infection, related pattern. All family members required...
ABSTRACT Helicobacter pylori infection is associated with altered gastric epithelial cell turnover. To evaluate the role of oxidative stress in death, cells were exposed to various strains H. , inflammatory cytokines, and hydrogen peroxide absence or presence antioxidant agents. Increased intracellular reactive oxygen species (ROS) detected using a redox-sensitive fluorescent dye, cytochrome c reduction assay, measurements glutathione. Apoptosis was evaluated by detecting DNA fragmentation...
Angiogenesis, the formation of new blood vessels from pre-existing vascular beds, is essential for tumor growth, invasion, and metastasis. Luteolin a common dietary flavonoid found in fruits vegetables. We studied antiangiogenic activity luteolin using vitro, ex vivo, vivo models. In vitro studies rat aortic ring assay showed that at non-toxic concentrations significantly inhibited microvessel sprouting proliferation, migration, invasion tube endothelial cells, which are key events process...
Histone modifications are critical in regulating gene expression, cell cycle, proliferation, and development. Relatively few studies have investigated whether Helicobacter pylori, the major cause of human gastric diseases, affects histone modification. We therefore effects H. pylori infection on a global promoter-specific manner epithelial cells. Infection cells by wild-type induced time- dose-dependent dephosphorylation H3 at serine 10 (H3 Ser10) decreased acetylation lysine 23, but had no...
Abstract In this study, we investigated the functional role of Akt and c-jun-NH2-kinase (JNK) signaling cascades in apigenin-induced apoptosis U937 human leukemia cells anti-leukemic activity apigenin vivo. Apigenin induced by inactivation with a concomitant activation JNK, Mcl-1 Bcl-2 downregulation, cytochrome c release from mitochondria, caspases. Constitutively active myristolated prevented caspase activation, apoptosis. Conversely, LY294002 dominant-negative construct potentiated cells....
To evaluate plasma chaperonin containing TCP1 complex subunit 3 (CCT3) and IQ-motif-containing GTPase-activating protein-3 (IQGAP3) as biomarker for hepatocellular carcinoma (HCC) screening diagnosis. Blood samples were collected from 126 HCC patients with HCC, 88 cirrhosis 50 healthy volunteers to detect α-fetoprotein (AFP), CCT3 IQGAP3 levels. Plasma AFP, protein levels measured by enzyme linked immunosorbent assay (ELISA). In the of patients, both significantly higher than in controls (P...
Helicobacter pylori (H. pylori) has characteristics of family cluster infection; however, its family-based infection status, related factors, and transmission pattern in central China, a high-risk area for H. gastric cancer, have not been evaluated. We investigated healthy households to understand patterns disease prevention.To investigate prevention.Blood samples survey questionnaires were collected from 282 families including 772 individuals. The recruited 10 selected communities the...
Helicobacter pylori infection is the major cause of gastric cancer, which remains an important health care challenge. Recent investigation in stem cell or progenitor biology has uncovered valuable information understanding gland renewal and maintenance homeostasis, they also provide clues for further defining mechanisms by cancer may originate progress. Lgr5, Villin-promoter, TFF2-mRNA Mist have recently been identified as stem/progenitor markers; their identification enriched our on...
This study aimed to investigate the presence of plasma minichromosome maintenance complex component 6 (MCM6) mRNA and protein levels in hepatocellular carcinoma (HCC) patients evaluate their diagnostic value for HCC.Blood samples were collected from 61 HCC 29 cirrhotic patients, 30 healthy individuals. Circulating RNA was extracted all samples. The MCM6 amplified quantified by real-time polymerase chain reaction. Plasma α-fetoprotein (AFP) measured enzyme-linked immunosorbent assay.In...
Background: The role of miR-200a-3p in gastric cancer (GC) remain unclear. Materials and methods: expression 65 paired GC adjacent tissues (AT) were evaluated by quantitative real-time PCR (qRT-PCR) Western blot. Cell proliferation, cell cycle, migration assessed growth counting assay, cycle analysis, transwell respectively. target was analyzed dual-luciferase reporter assay. Results: significantly reduced compared with AT. closely associated clinicopathological features (P < .05). SGC-7901...
Type I Helicobacter pylori (H. pylori) infection causes severe gastric inflammation and is a predisposing factor for carcinogenesis. However, its status in stepwise disease progression this cancer prevalent area has not been evaluated; it also known impact on commonly used epidemiological risk markers such as gastrin-17 (G-17) pepsinogens (PGs) during clinical practice.To explore the prevalence of type II H. their G-17 PG levels practice.Thirty-five hundred seventy-two hospital admitted...
Helicobacter pylori (H. pylori) infection and its related diseases are substantial public health burden for highly infected areas. Recently, a novel family-based H. control management (FBCM) strategy is introduced prevention control. However, cost-effectiveness has not been evaluated. We conducted this economic evaluation to investigate the of FBCM, screen-and-treat, no-screen strategies in Chinese population.Cost-effectiveness analysis was performed using decision tree Markov model....
Abstract Background Antibiotic resistance emerges as a major issue for Helicobacter pylori (H . pylori) treatment. High‐dose dual therapy has recently shown encouraging results in H eradication, but it yet to be validated this highly infected area; is also not known if concept can extended antibiotics other than amoxicillin, and factors that affect the eradication. We investigate rabeprazole plus amoxicillin or furazolidone regimens could first‐line curing rate. Methods This single‐center,...
ABSTRACT Background. Helicobacter pylori is the major pathogen causing chronic gastritis and peptic ulcer disease closely linked to gastric malignancy. We have previously shown that H. ‐induced NF‐κB activation interleukin (IL)‐8 secretion are mediated by Toll‐like receptor (TLR) 2 in epithelial cells. However, TLR2‐mediated global gene expression profile of cell during infection still unknown. The goal this study was identify TLR2‐regulated genes cells induced pylori. Materials methods....
Helicobacter pylori infection activates mitogen-activated protein kinases (MAPK) and modulates cell proliferation apoptosis. However, the relationship between H. MAPK signaling in controlling apoptosis is not clear, nor has role of on gastric epithelial cycle been established. Therefore, we investigated effects inhibition these processes.Gastric lines (AGS MKN45) were infected with and/or treated inhibitors. Cell measured by flow cytometry. proteins monitored western blot count,...