A5089465765- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Gastroesophageal reflux and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Extracellular vesicles in disease
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Abdominal vascular conditions and treatments
- Cancer-related molecular mechanisms research
- Eosinophilic Esophagitis
- Radiomics and Machine Learning in Medical Imaging
- Macrophage Migration Inhibitory Factor
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Heavy Metal Exposure and Toxicity
- Tumors and Oncological Cases
- Histiocytic Disorders and Treatments
- Meta-analysis and systematic reviews
- Musculoskeletal pain and rehabilitation
- Biomarkers in Disease Mechanisms
- Spine and Intervertebral Disc Pathology
Second Military Medical University
2001-2025
Changhai Hospital
2016-2025
Chinese Medical Doctor Association
2024
National Clinical Research Center for Digestive Diseases
2024
China Association for Science and Technology
2020
Shanghai Association for Science and Technology
2020
University of Oklahoma Health Sciences Center
2018
Huazhong University of Science and Technology
2013
Background and aims Current practice on Helicobacter pylori infection mostly focuses individual-based care in the community, but family-based H. management has recently been suggested as a better strategy for control. However, status, risk factors transmission pattern remain to be elucidated. Methods From September 2021 December 2021, 10 735 families (31 098 individuals) were enrolled from 29 of 31 provinces mainland China examine infection, related pattern. All family members required...
Background: Acute pancreatitis (AP) is an internal medical emergency disease, with fatal complications including acute lung injury (ALI). Recent studies have highlighted the critical roles of exosomal microRNAs (miRNAs) in AP-ALI. In present study, we aim to investigate role serum miR-216a AP-ALI and its underlying mechanisms. Methods: The levels patients rat models AP were assessed via real-time quantitative PCR (qRT-PCR) analysis. Patient blood exosomes isolated co-cultured HUVECs....
Abstract Background and Aim China is a country with high prevalence of Helicobacter pylori ( H. ) infection, which in turn closely related to the occurrence gastric cancer. Therefore, risks infection cancer are highly overlapping, prevention treatment necessary prevent Methods Based on evidence‐based medicine Delphi method, National Clinical Medical Research Center for Digestive Disease along Early Gastrointestinal Cancer Prevention Treatment Alliance organized dozens experts fields...
Conventionally, disconnected pancreatic duct syndrome is treated surgically. Endoscopic management associated with lesser morbidity and mortality than that observed surgery shows similar success rates. However, limited data are available in this context. We evaluated the efficacy of endotherapeutic for syndrome.We prospectively obtained patients between September 2008 January 2016. Demographic clinical were assessed, factors affecting outcomes statistically analyzed.Thirty-one underwent 40...
Abstract Pseudogene pituitary tumor-transforming 3 (PTTG3P) is emerging as a key player in the development and progression of cancer. However, biological role clinical significance PTTG3P pancreatic ductal adenocarcinoma (PDAC) remain unclear. Here, we found that was significantly upregulated PDAC tissues. Elevated expression correlated with larger tumor size worse differentiation, reduced overall survival. Bioinformatics experimental evidence revealed promoted malignant phenotypes FoxM1...
ABSTRACT Objective To prepare a set of practice guidelines to standardize the entire process, from diagnosis treatment and follow-up, for pancreatic pseudocysts walled-off necrosis. Methods Thirty-six experts in fields digestive endoscopy, surgery, interventional radiology, others presented their opinions via discussions online conferences by referring patient, intervention, comparison, outcomes principles then reviewed evidence statements using Delphi method reach consensus. The consensus...
Background: To overcome the limitations of using cytological specimen alone for diagnosis challenging pancreatic lesions, biopsy needles have been developed to procure histological specimens during EUS, especially discrimination several specific tumors requiring adequate samples. The aim this study was compare diagnostic yield EUS-guided 22-gauge (G) fine needle aspiration (FNA) and 22G (FNB) sampling masses.Methods: We conducted a retrospective all performed between November 2012 April...
The role of microRNA-132 in human pancreatic ductal adenocarcinomas is still ambiguous. We explored the association between and adenocarcinoma prognosis. expression 50 tissue samples cell lines was examined, its prognosis assessed. Functional analysis factors downstream were investigated. Kaplan-Meier survival curves showed that high a significant prognostic factor for 1-year patients with ( P = .028). Multivariate overall indicated an independent .044). Low associated poor adenocarcinoma....
Abstract Background and Aim The effect of solid debris on walled‐off necrosis (WON) drainage remains unknown. Our study evaluated the role in endoscopic ultrasound (EUS)‐guided WON compared lumen‐apposing metal stent (LAMS) with double‐pigtail plastic (DPPS). Methods We retrospectively consecutive patients who underwent EUS‐guided our center over a 9‐year period. amount was assessed computed tomography or magnetic resonance imaging EUS images. Results From 2011 to 2019, 84 were included. In...
Endoscopic ultrasonography (EUS)-guided drainage has become the first-line therapy for late peri-pancreatic fluid collection (PFC). Double pigtail plastic stents (DPPS) and lumen-apposing metal (LAMS) are commonly used PFC drainage. Recently, a multi-institutional consensus on recommended that LAMS should be standard care patients with walled-off necrosis (WON). However, given poor quality of evidence, we aim to perform large-scale randomized controlled trial determine whether is superior...
Gastric precancerous conditions are generally considered to play an essential role in the gastric carcinogenesis cascade. This study identified risk factors of a nationwide multicenter cross-sectional study.Individuals who made their visit 115 hospitals China for cancer screening were recruited. Lifestyle habits and personal information collected through series questionnaires. Serum biomarker test (pepsinogen I, pepsinogen II, gastrin-17, anti-Helicobacter pylori immunoglobulin G antibody)...