A5001241887- Astrophysical Phenomena and Observations
- Pulsars and Gravitational Waves Research
- Gamma-ray bursts and supernovae
- Particle Detector Development and Performance
- Astrophysics and Cosmic Phenomena
- Radiation Detection and Scintillator Technologies
- Superconducting and THz Device Technology
- Nuclear Physics and Applications
- SARS-CoV-2 and COVID-19 Research
- Neonatal Respiratory Health Research
- Cytomegalovirus and herpesvirus research
- Radio Astronomy Observations and Technology
- COVID-19 Clinical Research Studies
- Neonatal and fetal brain pathology
- Advanced X-ray and CT Imaging
- Calibration and Measurement Techniques
- High-pressure geophysics and materials
- Infrared Target Detection Methodologies
- Advancements in Battery Materials
- Advanced Semiconductor Detectors and Materials
- Advanced Battery Materials and Technologies
- Long-Term Effects of COVID-19
- Physics of Superconductivity and Magnetism
- Microwave Engineering and Waveguides
- Astronomy and Astrophysical Research
Chinese Academy of Sciences
2014-2025
Institute of High Energy Physics
2014-2025
Guangzhou Medical University
2013-2025
Tongji Hospital
2012-2024
Huazhong University of Science and Technology
2012-2024
Shanghai Tongji Urban Planning and Design Institute
2024
Tongji University
2024
Shanghai University of Engineering Science
2015-2023
Fujian Agriculture and Forestry University
2022
Guangzhou Women and Children Medical Center
2013-2021
In mammalian cells, DNA methylation critically regulates gene expression and thus has pivotal roles in myriad of physiological pathological processes. Here we report a novel method for targeted demethylation using the widely used clustered regularly interspaced short palindromic repeat (CRISPR)-Cas system. Initially, modified single guide RNAs (sgRNAs) (sgRNA2.0) were constructed by inserting two copies bacteriophage MS2 RNA elements into conventional sgRNAs, which would facilitate tethering...
GRB 221009A is the brightest gamma-ray burst ever detected since discovery of this kind energetic explosions. However, an accurate measurement prompt emission properties very challenging due to its exceptional brightness. With joint observations \textit{Insight}-HXMT and GECAM-C, we made unprecedentedly during first $\sim$1800 s 221009A, including precursor, main (ME, which dominates in flux), flaring early afterglow, hard X-ray soft band from $\sim$ 10 keV 6 MeV. Based on GECAM-C...
Abstract The early afterglow of a gamma-ray burst (GRB) can provide critical information on the jet and progenitor GRB. extreme brightness GRB 221009A allows us to probe its in unprecedented detail. In this Letter, we report comprehensive observation results (from T 0 +660 s +1860 s, where is Insight-HXMT/HE trigger time) X-ray/gamma-ray energy band 20 keV MeV) by Insight-HXMT High Energy X-ray Telescope, GECAM-C, Fermi/Gamma-ray Burst Monitor. We find that spectrum keV–20 MeV be well...
Abstract The milestone discovery of GW170817-GRB 170817A-AT 2017gfo has shown that gravitational waves (GWs) could be produced during the merger a neutron star–neutron star/black hole and in electromagnetic (EM) waves, gamma-ray burst (GRB) kilonova (KN) are generated sequence after merger. Observationally, however, EM properties before phase still unclear. Here we report peculiar precursor KN-associated long-duration GRB 211211A, providing evidence This lasts ∼0.2 s, waiting time between...
Abstract Fast radio bursts (FRBs) are short pulses observed in band from cosmological distances, some of which emit repeating bursts. The physical origins these mysterious events have been subject to wide speculations and heated debates. One class models invoke soft gamma-ray repeaters (SGRs), or magnetars, as the sources FRBs. Magnetars rotating neutron stars with extremely strong magnetic field can sporadically X-ray (keV) (sub-MeV) duration 102 s 102 s. However, even though bright no...
The origin(s) and mechanism(s) of fast radio bursts (FRBs), which are short pulses from cosmological distances, have remained a major puzzle since their discovery. We report strong Quasi-Periodic Oscillation(QPO) 40 Hz in the X-ray burst magnetar SGR J1935+2154 associated with FRB 200428, significantly detected Hard Modulation Telescope (Insight-HXMT) also hinted by Konus-Wind data. QPOs only been rarely detected; our 3.4 sigma (p-value is 2.9e-4) detection QPO reported here reveals...
Children usually develop less severe symptoms responding to Coronavirus Disease 2019 (COVID-19) than adults. However, little is known about the molecular alterations and pathogenesis of COVID-19 in children.
Abstract The heritage value of the historic urban countryside, as a remnant in transition between boundary and natural environment, is consequence spatial temporal evolution city. However, through repeated social transformations, conflicts construction cultural landscape preservation have increased, resulting gradual disappearance their heritage. This study takes Sheshan Urban Countryside Historic District Shanghai interprets layers Sheshan's into five periods, Emergence, Development...
A superconducting quantum interference device (SQUID), functioning as a nonlinear response device, typically requires the incorporation of flux-locked loop (FLL) circuit to facilitate linear amplification current signal transmitted through transition-edge sensor (TES) across large dynamic range. This work presents reasonable model SQUID-FLL readout system, based on digital proportional-integral-differential (PID) flux negative feedback algorithm. investigates effect $V$-$\phi$ shape...
Early diagnosis of Kawasaki disease (KD) allows timely treatment to be initiated, thereby preventing coronary artery aneurysms in children. However, it is challenging due the subjective nature diagnostic criteria. This study aims develop a machine learning prediction model using routine blood tests distinguish children with KD from other febrile illnesses Chinese within first five days fever onset. The retrospective cross-sectional data for this was collected records Guangzhou Women and...
Abstract Searching for primordial gravitational wave in cosmic microwave background (CMB) polarization signal is one of the key topics modern cosmology. Cutting-edge CMB telescopes requires thousands pixels to maximize mapping speed. Using modular design, telescope focal plane simplified as several detector modules. Each module has hundreds including antenna arrays, and readout arrays. The beam defining component, determine overall optical response module. In this article, we present...
Methanol is predominantly produced by a coal-to-methanol process in China. However, this criticized high CO2 emissions because of the carbon contents coal. The emission and low resource utilization efficiency greatly weaken competitiveness coal-to methanol industry. Coke oven gas, one hydrogen-rich resources, used as fuel or directly discharged. This leads to waste valuable resources serious economic losses. Aiming at effective coke study proposes novel integrated with for improving system...
The milestone of GW 170817-GRB 170817A-AT 2017gfo has shown that gravitational wave (GW) is produced during the merger neutron star-neutron star/black hole and in electromagnetic (EM) a gamma-ray burst (GRB) kilonovae (KN) are generated sequence after merger. Observationally, however, EM property still unclear. Here we report peculiar precursor KN-associated long GRB 211211A. duration $\sim$ 0.2 s, waiting time between main emission (ME) 1 which about same as interval 170817 170817A....
With the rapid development of digital economy, promoting green innovation through digitalization has become an important means for manufacturing enterprises to improve their core competitiveness. However, existing studies focus more on enterprise technology than innovation, and empirical tests mostly use regional-level data rather enterprise-level data. This paper empirically examines impact effect mechanism in using a sample Chinese A-share listed from 2013–2019. It is found that:...